Detailed information of TA system TA053792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1129766..1130418
• Replicon: chromosome
• Accession: NZ_CP011303
• Organism: Serratia liquefaciens strain HUMV-21

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: XJ20_RS05275
• Protein ID: WP_046372937.1
• Coordinates: 1130032..1130418 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A379YGI8
• Locus tag: XJ20_RS05270
• Protein ID: WP_020828097.1
• Coordinates: 1129766..1130029 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XJ20_RS05255	1126155..1127072	-	918	WP_046372935.1	lipid kinase YegS	-
XJ20_RS05260	1127546..1128898	-	1353	WP_046372936.1	tRNA 5-hydroxyuridine modification protein YegQ	-
XJ20_RS05265	1129076..1129414	-	339	WP_020828098.1	YegP family protein	-
XJ20_RS05270	1129766..1130029	+	264	WP_020828097.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
XJ20_RS05275	1130032..1130418	+	387	WP_046372937.1	type II toxin-antitoxin system VapC family toxin	Toxin
XJ20_RS05280	1130425..1131141	-	717	WP_020828095.1	two-component system response regulator BaeR	-
XJ20_RS05285	1131141..1132523	-	1383	WP_046372938.1	two-component system sensor histidine kinase BaeS	-
XJ20_RS05290	1132523..1133953	-	1431	WP_020828093.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14047.19 Da
• Isoelectric Point: 7.2417

>T53792 WP_046372937.1 NZ_CP011303:1130032-1130418 [Serratia liquefaciens]
MYMFDTNTVSQLFRRHPRLLSLMEKIPPSAVCISSITQAELLYGVAKRQNLALKATVAAFLDSVTVYAWDSEAAHCYGTL
RAEMTQKGRVIGALDQLIAAHAQSRGATIVTNDQAFAMVPGLTVEDWT

Nucleotide

• Length: 387 bp

>T53792 NZ_CP011303:1130032-1130418 [Serratia liquefaciens]
ATGTATATGTTTGACACCAATACGGTCAGCCAACTGTTCCGCCGGCATCCCCGCTTGCTGAGCCTAATGGAAAAAATCCC
GCCTTCCGCGGTATGCATTTCCAGCATTACGCAGGCGGAACTGCTTTATGGCGTGGCCAAGCGGCAGAACCTTGCGCTGA
AAGCGACGGTCGCGGCATTTCTTGATTCCGTGACGGTATATGCCTGGGACAGTGAAGCCGCGCACTGCTATGGCACGCTG
CGGGCGGAAATGACGCAAAAGGGGCGGGTGATAGGGGCCCTGGATCAGCTTATTGCCGCCCACGCGCAGAGCCGCGGAGC
GACAATAGTGACTAACGACCAGGCGTTTGCCATGGTGCCAGGCCTGACGGTAGAAGACTGGACCTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10091.38 Da
• Isoelectric Point: 5.8701

>AT53792 WP_020828097.1 NZ_CP011303:1129766-1130029 [Serratia liquefaciens]
MERVAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIEKTQVPHDFLAADERQQGSATR
DPFAGEE

Nucleotide

• Length: 264 bp

>AT53792 NZ_CP011303:1129766-1130029 [Serratia liquefaciens]
ATGGAAAGGGTCGCGAAACTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCCGTGGAATTCGAATTTGATACAGA
TCGTGTGTATATCCGCCGCGATCGGGAGGGAAACGTGATTTTATCTAAATATCCGGCCAAACCTGACAGCTGGGCTCCGC
TGCTGCAAATGATCGAAAAAACGCAGGTACCGCATGACTTTCTGGCGGCTGATGAACGTCAGCAGGGCAGTGCCACCCGC
GATCCGTTCGCCGGGGAAGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A379YGI8