Detailed information of TA system TA053791

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 701054..701723
• Replicon: chromosome
• Accession: NZ_CP011303
• Organism: Serratia liquefaciens strain HUMV-21

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: XJ20_RS03195
• Protein ID: WP_020828475.1
• Coordinates: 701301..701723 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A7W4F6J9
• Locus tag: XJ20_RS03190
• Protein ID: WP_020828476.1
• Coordinates: 701054..701320 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XJ20_RS03165	696193..697518	+	1326	WP_046372712.1	MHS family MFS transporter	-
XJ20_RS03170	697559..698167	-	609	WP_020828480.1	HD domain-containing protein	-
XJ20_RS03175	698351..699025	+	675	WP_020828479.1	hemolysin III family protein	-
XJ20_RS03180	699190..699687	+	498	WP_020828478.1	DUF2165 domain-containing protein	-
XJ20_RS03185	699745..700731	-	987	WP_046372713.1	tRNA-modifying protein YgfZ	-
XJ20_RS03190	701054..701320	+	267	WP_020828476.1	FAD assembly factor SdhE	Antitoxin
XJ20_RS03195	701301..701723	+	423	WP_020828475.1	protein YgfX	Toxin
XJ20_RS03200	701723..702418	+	696	WP_046372714.1	two-component system response regulator CreB	-
XJ20_RS03205	702415..703833	+	1419	WP_046372715.1	two-component system sensor histidine kinase CreC	-
XJ20_RS03210	703918..705282	+	1365	WP_046372716.1	cell envelope integrity protein CreD	-
XJ20_RS03215	705319..705837	-	519	WP_020828471.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16577.54 Da
• Isoelectric Point: 10.6957

>T53791 WP_020828475.1 NZ_CP011303:701301-701723 [Serratia liquefaciens]
VAQWRCDVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLENQRVGWQGQ
EWQLVKQPWMLRFGILLTLQPMQGKKRRRLWLASDSMAKAEWRHLRQQLLYPPASDDEEP

Nucleotide

• Length: 423 bp

>T53791 NZ_CP011303:701301-701723 [Serratia liquefaciens]
GTGGCCCAGTGGCGATGTGATGTTCGTATTTCCTGGCGCACCCAGTTACTTTCGCTGTTGACGCATGGCGTTCTGATCCT
GCTGATCCTGATTTCACCCTGGCCGGAAGGCTACGGGCCAATCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTGAATGCA
TTCGTAGCCAAAAACGCATTGCGTCGCGTCAGGGGGAGTTGCGCCTGCTCGAGAACCAGCGTGTGGGCTGGCAAGGCCAG
GAATGGCAGTTGGTCAAGCAACCCTGGATGCTGCGCTTCGGTATTCTGCTGACGTTGCAACCGATGCAGGGGAAAAAGCG
TCGTCGCTTATGGTTGGCTTCCGACAGCATGGCCAAGGCCGAATGGCGACATTTGCGCCAACAGCTGTTGTATCCGCCGG
CCAGTGATGATGAGGAACCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10500.99 Da
• Isoelectric Point: 5.0990

>AT53791 WP_020828476.1 NZ_CP011303:701054-701320 [Serratia liquefaciens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDRLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT53791 NZ_CP011303:701054-701320 [Serratia liquefaciens]
ATGGATATTAATAACAAAGCACGTATTCACTGGGCTTGTCGCCGTGGCATGCGTGAGCTGGACATCTCGATCATGCCGTT
CTTCGAATATGAGTACGATCGGTTGAATGACACAGACAAAGCGCTGTTTATCCGCCTGCTTGAGAGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCTCCGCAGGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7W4F6J9