Detailed information of TA system TA053789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 114500..115065
• Replicon: chromosome
• Accession: NZ_CP011303
• Organism: Serratia liquefaciens strain HUMV-21

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: XJ20_RS00510
• Protein ID: WP_020837304.1
• Coordinates: 114500..114778 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A380ARC2
• Locus tag: XJ20_RS00515
• Protein ID: WP_020837302.1
• Coordinates: 114796..115065 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XJ20_RS00490	110662..111000	-	339	WP_041415733.1	PTS lactose/cellobiose transporter subunit IIA	-
XJ20_RS00495	111358..111927	+	570	WP_020837308.1	peptidylprolyl isomerase A	-
XJ20_RS00500	112089..113774	+	1686	WP_046372487.1	sensor histidine kinase	-
XJ20_RS00505	113774..114499	+	726	WP_046372488.1	two-component system response regulator BtsR	-
XJ20_RS00510	114500..114778	-	279	WP_020837304.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XJ20_RS00515	114796..115065	-	270	WP_020837302.1	hypothetical protein	Antitoxin
XJ20_RS00520	115291..116817	+	1527	WP_046372489.1	DUF853 family protein	-
XJ20_RS00525	116922..117497	+	576	WP_046372490.1	aminodeoxychorismate synthase component II	-
XJ20_RS00530	117629..118846	+	1218	WP_046372491.1	aspartate aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10374.00 Da
• Isoelectric Point: 9.8344

>T53789 WP_020837304.1 NZ_CP011303:c114778-114500 [Serratia liquefaciens]
VKLKWTDPTIADRMAIYDYLASKNPIAAAEIDALISAAASQLSRNPSSGKVGRVSGTREWVIHHFYLLIYEVKNDLLIIL
AVVHSRRQWPKD

Nucleotide

• Length: 279 bp

>T53789 NZ_CP011303:c114778-114500 [Serratia liquefaciens]
GTGAAGCTAAAGTGGACGGATCCCACAATTGCTGACCGTATGGCAATTTATGACTATCTTGCGTCAAAGAACCCGATAGC
TGCCGCAGAGATTGATGCTTTGATTTCTGCGGCGGCAAGCCAACTATCCCGAAACCCATCAAGTGGCAAAGTGGGCCGGG
TTTCAGGTACACGTGAATGGGTCATTCATCATTTTTACCTACTGATTTATGAAGTAAAAAATGACCTTCTTATTATTTTG
GCAGTCGTACATTCCCGCCGGCAATGGCCAAAGGATTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10373.64 Da
• Isoelectric Point: 5.2281

>AT53789 WP_020837302.1 NZ_CP011303:c115065-114796 [Serratia liquefaciens]
MSESTVVIRVDDELKIAFASAAKAADRTASQLLRDFMRDFVSRQSQQKEYEQWLQEKVDLSRKALQEGRVVDNEDVEAYF
AERRAKSMR

Nucleotide

• Length: 270 bp

>AT53789 NZ_CP011303:c115065-114796 [Serratia liquefaciens]
ATGTCTGAATCTACCGTGGTTATCCGCGTGGATGACGAGTTAAAAATAGCTTTTGCCAGTGCGGCCAAAGCAGCGGATCG
AACGGCATCTCAGCTTTTACGCGATTTCATGCGAGATTTTGTCAGTCGACAATCGCAGCAAAAAGAGTATGAACAGTGGT
TGCAGGAGAAGGTCGATTTAAGCCGAAAAGCGCTCCAGGAAGGAAGAGTGGTTGATAATGAGGACGTTGAGGCTTATTTC
GCCGAGCGCAGGGCAAAATCAATGCGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A380ARC2