Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 6155914..6157164 Replicon chromosome
Accession NZ_CP011301
Organism Burkholderia cepacia strain LO6

Toxin (Protein)


Gene name vapC Uniprot ID A0A892IA44
Locus tag XM57_RS27530 Protein ID WP_006766297.1
Coordinates 6156565..6157164 (+) Length 200 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A892I3E7
Locus tag XM57_RS27525 Protein ID WP_035974448.1
Coordinates 6155914..6156471 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XM57_RS31110 6151294..6151791 - 498 WP_123806756.1 hypothetical protein -
XM57_RS27505 6152082..6152294 + 213 WP_105773927.1 transposase -
XM57_RS30085 6152572..6152802 - 231 WP_105773928.1 integrase core domain-containing protein -
XM57_RS27515 6152792..6154050 - 1259 Protein_5479 IS256 family transposase -
XM57_RS27520 6154166..6155569 - 1404 WP_006766295.1 hypothetical protein -
XM57_RS27525 6155914..6156471 + 558 WP_035974448.1 helix-turn-helix domain-containing protein Antitoxin
XM57_RS27530 6156565..6157164 + 600 WP_006766297.1 HD domain-containing protein Toxin
XM57_RS27540 6157506..6159044 - 1539 WP_006766298.1 MFS transporter -
XM57_RS27545 6159217..6160122 + 906 WP_035974451.1 LysR family transcriptional regulator -
XM57_RS27550 6160209..6161348 - 1140 WP_006766300.1 enoyl-CoA hydratase/isomerase family protein -
XM57_RS27555 6161345..6162142 - 798 WP_035974452.1 enoyl-CoA hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-168)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-49)


Sequences

Toxin        


Download         Length: 200 a.a.        Molecular weight: 21892.64 Da        Isoelectric Point: 5.1098

>T53788 WP_006766297.1 NZ_CP011301:6156565-6157164 [Burkholderia cepacia]
MTPDTIHARLDFLREAERLKDVLRSGRTSSGRAESTAEHSWRLCLMALAFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERNDLLTLTAALDGPLRDEIVALWDEYEAVATPEARAAKALDKLETILQHNQGDNPPDFDYAFNLDY
GRRYTDAAPLFIAIRAVVDADTQRRIDARAHTACTKGSA

Download         Length: 600 bp

>T53788 NZ_CP011301:6156565-6157164 [Burkholderia cepacia]
ATGACTCCCGACACGATTCACGCACGACTGGATTTTCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGAGCGGACGCGCCGAAAGCACGGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTGGCGTTCGCCGACGCGC
TGCCCGGCGTCGACACGCTGAAGCTGCTGAAGCTGTGCGTCGTGCACGATCTCGGCGAGGCGCTGCACGGCGACATTCCG
GCGATCGAGCAAGCCGCGCATCCGGACAAGAGCGCGCACGAGCGCAACGATCTGCTGACGCTGACGGCGGCGCTCGACGG
CCCGCTGCGCGACGAGATCGTCGCGCTGTGGGACGAATATGAAGCGGTCGCGACGCCGGAAGCCCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATCCTGCAGCACAACCAGGGCGACAACCCGCCCGATTTCGATTACGCGTTCAATCTCGACTAT
GGCCGGCGCTACACGGATGCGGCGCCGCTGTTCATCGCGATCCGCGCGGTCGTCGATGCGGACACGCAACGCAGAATCGA
CGCACGCGCGCACACCGCTTGCACGAAGGGTTCCGCATGA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20283.30 Da        Isoelectric Point: 8.8096

>AT53788 WP_035974448.1 NZ_CP011301:6155914-6156471 [Burkholderia cepacia]
MAAPALHTPPLGPQLKRWRVLHRIKQSHAAELFGVAQSTISRWEAGIQQMSADERATAERLLAAHLDSAGDHALARLIAD
SAGRMHLVCDLTHRLLACSPLRAAEFSQPLPLLLGTSLWRYATPEIVRMESALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSRCRWTRMTLSDGSAVRLVETL

Download         Length: 558 bp

>AT53788 NZ_CP011301:6155914-6156471 [Burkholderia cepacia]
ATGGCAGCGCCCGCACTTCATACGCCACCGCTGGGCCCGCAACTGAAGCGCTGGCGCGTGCTGCACCGGATAAAGCAGAG
CCACGCGGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCATCCAGCAGATGTCCGCCGACG
AGCGCGCGACGGCGGAACGTCTGCTCGCCGCGCATCTCGATTCCGCCGGCGACCATGCACTCGCGCGGCTGATCGCGGAC
AGCGCGGGCCGCATGCATCTGGTGTGCGACCTCACGCATCGTCTGCTCGCGTGCTCGCCGCTGCGTGCGGCCGAGTTCTC
GCAGCCGCTGCCGCTGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAGATCGTCCGCATGGAATCGGCGCTCG
ACACGCTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAGTTCGACACCGGCGCAAACGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCGATGCCGCTGGACGCGGATGACGCTGTCGGACGGATCGGCGGTGCGTCTGGTCGAAACGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References