Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5912426..5914170 Replicon chromosome
Accession NZ_CP011301
Organism Burkholderia cepacia strain LO6

Toxin (Protein)


Gene name doc Uniprot ID A0A892IG78
Locus tag XM57_RS26465 Protein ID WP_006766124.1
Coordinates 5913280..5914170 (-) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A892IEP8
Locus tag XM57_RS26460 Protein ID WP_006766123.1
Coordinates 5912426..5913283 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XM57_RS26440 5907487..5908977 - 1491 WP_035974286.1 aldehyde dehydrogenase -
XM57_RS26445 5909069..5909896 - 828 WP_006766122.1 aspartate dehydrogenase -
XM57_RS26450 5909889..5911556 - 1668 WP_035974287.1 thiamine pyrophosphate-binding protein -
XM57_RS26455 5911549..5912346 - 798 WP_035974289.1 SDR family oxidoreductase -
XM57_RS26460 5912426..5913283 - 858 WP_006766123.1 IclR family transcriptional regulator Antitoxin
XM57_RS26465 5913280..5914170 - 891 WP_006766124.1 alpha/beta fold hydrolase Toxin
XM57_RS26470 5914189..5914716 - 528 WP_035975316.1 cupin domain-containing protein -
XM57_RS26475 5914744..5915514 - 771 WP_035975317.1 SDR family oxidoreductase -
XM57_RS26480 5915507..5916577 - 1071 WP_006766127.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
XM57_RS26485 5916639..5916950 - 312 WP_006766128.1 hypothetical protein -
XM57_RS26490 5916952..5917269 - 318 WP_006766129.1 non-heme iron oxygenase ferredoxin subunit -
XM57_RS26495 5917714..5918793 + 1080 WP_035974291.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(49-276)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 30188.38 Da        Isoelectric Point: 6.6302

>T53787 WP_006766124.1 NZ_CP011301:c5914170-5913280 [Burkholderia cepacia]
MTVIEKRERAAAFAALLEQFPEQRCAAGAAGTIGYREAGAQQADRALPVVLLHGIGSGAASWVRQLDALGAVRRVLAWDA
PGYGASTPVRAASPVAADYAAALDAWLDALGIERCVVVGHSLGAIVAGGMVSAMPARIAGLLLISPAGGYGSASADTRNA
RRDARLAMLAALGPAGLAEQRSGNMLSGFASDDARAWVRWNMARIVPDGYAQATHLLANADLAADVAGFAGHAAVAVGAN
DAITPPAACERIAAALGVELQVVPQAGHAGYVEAPAIYSALIDAFCRSCDTQRRPA

Download         Length: 891 bp

>T53787 NZ_CP011301:c5914170-5913280 [Burkholderia cepacia]
ATGACCGTCATCGAAAAGCGCGAACGCGCAGCGGCTTTCGCCGCGCTGCTCGAGCAGTTTCCGGAGCAGCGCTGCGCGGC
CGGTGCGGCCGGCACGATCGGCTATCGCGAGGCCGGCGCGCAGCAAGCGGACCGTGCGCTGCCCGTCGTGCTGCTGCACG
GAATCGGCTCGGGCGCCGCATCGTGGGTGCGTCAGCTCGATGCGCTCGGCGCGGTGCGCCGCGTGCTCGCGTGGGACGCG
CCCGGCTACGGCGCATCGACGCCGGTGCGCGCGGCATCGCCGGTCGCCGCCGATTACGCGGCCGCGCTGGATGCGTGGCT
TGACGCGCTCGGCATCGAGCGCTGCGTGGTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGCATGGTGAGCGCGA
TGCCGGCGCGAATCGCCGGGTTGCTGCTGATCTCGCCGGCGGGCGGCTACGGCAGCGCGAGCGCCGATACGCGCAACGCG
CGCCGCGACGCGCGGCTCGCGATGCTCGCGGCGCTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAATATGCTGTC
CGGCTTCGCGAGCGACGATGCGCGTGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGACGGCTACGCGCAGGCGA
CGCATCTGCTCGCGAACGCCGATCTGGCGGCCGACGTCGCCGGTTTCGCCGGTCATGCGGCGGTGGCCGTCGGTGCAAAC
GACGCGATCACGCCGCCCGCTGCATGCGAACGGATCGCGGCGGCGCTCGGCGTCGAACTGCAGGTGGTTCCGCAGGCCGG
CCACGCCGGTTACGTCGAAGCGCCGGCCATCTATTCCGCGCTGATCGACGCGTTCTGCCGATCGTGCGACACGCAGCGGA
GGCCCGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31426.97 Da        Isoelectric Point: 8.0592

>AT53787 WP_006766123.1 NZ_CP011301:c5913283-5912426 [Burkholderia cepacia]
MSAPLQRQAADDAKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYR
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLQELYALYPERTLNRMTSATPETVDALYEAIREDARRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFMKALGLK

Download         Length: 858 bp

>AT53787 NZ_CP011301:c5913283-5912426 [Burkholderia cepacia]
ATGAGCGCGCCGCTGCAACGCCAGGCAGCCGACGACGCGAAGGCCGATGCCGGCTACGTCGTGCCGGGGCTCGAGCGCGG
GCTGCGGATTCTCGCGGAGTTTTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGTATTCCGC
GCACGACGGTGTTTCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGACCGGAACTACCGG
CTCGGCATCGCGGTGCTGCGGCTCGGCTTCGAGTATCTGAGCTCGCTCGAGCTGACCGATCTCGGGCTGCCCGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGC
AAAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACGCACGGTCAC
GTGCTGATGGGCGACCTGTCGCTGCAGGAGCTGTACGCGCTGTATCCGGAGCGCACGCTGAACCGGATGACGAGCGCGAC
GCCGGAGACGGTCGATGCGCTGTACGAAGCGATCCGCGAAGACGCACGGCGCGGCTACGGGATCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGCCCCGAAATCGACGCGACGCTGATCGCGGACGGACTGATCGACAAGGTGCGGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTCATGAAGGCTTTGGGACTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References