Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 16525..17117 Replicon plasmid unnamed2
Accession NZ_CP011294
Organism Salmonella enterica subsp. diarizonae strain 11-01854

Toxin (Protein)


Gene name hicA Uniprot ID A0A1I9ZJC5
Locus tag UQ49_RS22725 Protein ID WP_000513532.1
Coordinates 16869..17117 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1I9ZJ49
Locus tag UQ49_RS22720 Protein ID WP_000681609.1
Coordinates 16525..16872 (-) Length 116 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UQ49_RS22680 11816..12157 - 342 WP_000730722.1 plasmid mobilization relaxosome protein MobC -
UQ49_RS22685 12526..12927 + 402 WP_021575837.1 hypothetical protein -
UQ49_RS22690 12945..13697 + 753 WP_000797966.1 conjugal transfer protein TraL -
UQ49_RS22695 13699..14406 + 708 WP_063390999.1 hypothetical protein -
UQ49_RS22700 14507..14866 + 360 WP_024147837.1 hypothetical protein -
UQ49_RS22705 14868..15194 + 327 WP_000206697.1 hypothetical protein -
UQ49_RS22710 15454..15753 - 300 WP_000466320.1 type II toxin-antitoxin system HicB family antitoxin -
UQ49_RS22715 16255..16437 + 183 WP_001428470.1 hypothetical protein -
UQ49_RS22720 16525..16872 - 348 WP_000681609.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
UQ49_RS22725 16869..17117 - 249 WP_000513532.1 type II toxin-antitoxin system HicA family toxin Toxin
UQ49_RS22730 17582..17860 - 279 WP_000545937.1 hypothetical protein -
UQ49_RS22740 18409..18660 - 252 WP_052989132.1 transcriptional regulator -
UQ49_RS22745 18650..18910 - 261 WP_000702245.1 hypothetical protein -
UQ49_RS22750 18962..19186 - 225 WP_000814383.1 hypothetical protein -
UQ49_RS22755 19284..19493 - 210 WP_000866037.1 hypothetical protein -
UQ49_RS22760 19534..19857 - 324 WP_000427402.1 hypothetical protein -
UQ49_RS22770 20436..20765 - 330 WP_000855121.1 hypothetical protein -
UQ49_RS22780 21364..22029 + 666 WP_000532148.1 P-loop NTPase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..57955 57955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(25-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 83 a.a.        Molecular weight: 12233.67 Da        Isoelectric Point: 5.5500

>T53783 WP_000513532.1 NZ_CP011294:c17117-16869 [Salmonella enterica subsp. diarizonae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFF

Download         Length: 249 bp

>T53783 NZ_CP011294:c17117-16869 [Salmonella enterica subsp. diarizonae]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTT

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 17090.50 Da        Isoelectric Point: 5.5500

>AT53783 WP_000681609.1 NZ_CP011294:c16872-16525 [Salmonella enterica subsp. diarizonae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 348 bp

>AT53783 NZ_CP011294:c16872-16525 [Salmonella enterica subsp. diarizonae]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1I9ZJC5


Antitoxin

Source ID Structure
AlphaFold DB A0A1I9ZJ49

References