Detailed information of TA system TA053780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/Xre(antitoxin)
• Location: 18459..18960
• Replicon: plasmid unnamed2
• Accession: NZ_CP011291
• Organism: Salmonella enterica subsp. diarizonae strain 11-01853

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: A0A6X6XTU7
• Locus tag: UQ48_RS22745
• Protein ID: WP_000702245.1
• Coordinates: 18700..18960 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: -
• Locus tag: UQ48_RS22740
• Protein ID: WP_052989132.1
• Coordinates: 18459..18710 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UQ48_RS22695	13749..14456	+	708	WP_063390999.1	hypothetical protein	-
UQ48_RS22700	14557..14916	+	360	WP_024147837.1	hypothetical protein	-
UQ48_RS22705	14918..15244	+	327	WP_000206697.1	hypothetical protein	-
UQ48_RS22710	15504..15803	-	300	WP_000466320.1	type II toxin-antitoxin system HicB family antitoxin	-
UQ48_RS22715	16305..16487	+	183	WP_001428470.1	hypothetical protein	-
UQ48_RS22720	16575..16922	-	348	WP_000681609.1	type II toxin-antitoxin system HicB family antitoxin	-
UQ48_RS22725	16919..17167	-	249	WP_000513532.1	type II toxin-antitoxin system HicA family toxin	-
UQ48_RS22730	17632..17910	-	279	WP_000545937.1	hypothetical protein	-
UQ48_RS22740	18459..18710	-	252	WP_052989132.1	transcriptional regulator	Antitoxin
UQ48_RS22745	18700..18960	-	261	WP_000702245.1	hypothetical protein	Toxin
UQ48_RS22750	19012..19236	-	225	WP_000814383.1	hypothetical protein	-
UQ48_RS22755	19334..19543	-	210	WP_000866037.1	hypothetical protein	-
UQ48_RS22760	19584..19907	-	324	WP_000427402.1	hypothetical protein	-
UQ48_RS22770	20486..20815	-	330	WP_000855121.1	hypothetical protein	-
UQ48_RS22780	21414..22079	+	666	WP_000532148.1	P-loop NTPase	-
UQ48_RS25405	22153..22437	+	285	WP_001162371.1	hypothetical protein	-
UQ48_RS22790	22455..23051	-	597	WP_000125164.1	hypothetical protein	-
UQ48_RS22795	23201..23362	-	162	WP_001434039.1	type I toxin-antitoxin system Hok family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..58005	58005

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 12822.38 Da
• Isoelectric Point: 5.5500

>T53780 WP_000702245.1 NZ_CP011291:c18960-18700 [Salmonella enterica subsp. diarizonae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFF

Nucleotide

• Length: 261 bp

>T53780 NZ_CP011291:c18960-18700 [Salmonella enterica subsp. diarizonae]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT53780 WP_052989132.1 NZ_CP011291:c18710-18459 [Salmonella enterica subsp. diarizonae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT53780 NZ_CP011291:c18710-18459 [Salmonella enterica subsp. diarizonae]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: A0A6X6XTU7