Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 16575..17167 Replicon plasmid unnamed2
Accession NZ_CP011291
Organism Salmonella enterica subsp. diarizonae strain 11-01853

Toxin (Protein)


Gene name hicA Uniprot ID A0A1I9ZJC5
Locus tag UQ48_RS22725 Protein ID WP_000513532.1
Coordinates 16919..17167 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1I9ZJ49
Locus tag UQ48_RS22720 Protein ID WP_000681609.1
Coordinates 16575..16922 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UQ48_RS22680 11866..12207 - 342 WP_000730722.1 plasmid mobilization relaxosome protein MobC -
UQ48_RS22685 12576..12977 + 402 WP_021575837.1 hypothetical protein -
UQ48_RS22690 12995..13747 + 753 WP_000797966.1 conjugal transfer protein TraL -
UQ48_RS22695 13749..14456 + 708 WP_063390999.1 hypothetical protein -
UQ48_RS22700 14557..14916 + 360 WP_024147837.1 hypothetical protein -
UQ48_RS22705 14918..15244 + 327 WP_000206697.1 hypothetical protein -
UQ48_RS22710 15504..15803 - 300 WP_000466320.1 type II toxin-antitoxin system HicB family antitoxin -
UQ48_RS22715 16305..16487 + 183 WP_001428470.1 hypothetical protein -
UQ48_RS22720 16575..16922 - 348 WP_000681609.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
UQ48_RS22725 16919..17167 - 249 WP_000513532.1 type II toxin-antitoxin system HicA family toxin Toxin
UQ48_RS22730 17632..17910 - 279 WP_000545937.1 hypothetical protein -
UQ48_RS22740 18459..18710 - 252 WP_052989132.1 transcriptional regulator -
UQ48_RS22745 18700..18960 - 261 WP_000702245.1 hypothetical protein -
UQ48_RS22750 19012..19236 - 225 WP_000814383.1 hypothetical protein -
UQ48_RS22755 19334..19543 - 210 WP_000866037.1 hypothetical protein -
UQ48_RS22760 19584..19907 - 324 WP_000427402.1 hypothetical protein -
UQ48_RS22770 20486..20815 - 330 WP_000855121.1 hypothetical protein -
UQ48_RS22780 21414..22079 + 666 WP_000532148.1 P-loop NTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..58005 58005


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 12233.67 Da        Isoelectric Point: 5.5500

>T53779 WP_000513532.1 NZ_CP011291:c17167-16919 [Salmonella enterica subsp. diarizonae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFF

Download         Length: 249 bp

>T53779 NZ_CP011291:c17167-16919 [Salmonella enterica subsp. diarizonae]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTT

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 17090.50 Da        Isoelectric Point: 5.5500

>AT53779 WP_000681609.1 NZ_CP011291:c16922-16575 [Salmonella enterica subsp. diarizonae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 348 bp

>AT53779 NZ_CP011291:c16922-16575 [Salmonella enterica subsp. diarizonae]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9ZJC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1I9ZJ49

References