Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 10977..11569 Replicon plasmid unnamed1
Accession NZ_CP011290
Organism Salmonella enterica subsp. diarizonae strain 11-01853

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag UQ48_RS22495 Protein ID WP_000520549.1
Coordinates 10977..11225 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag UQ48_RS22500 Protein ID WP_000681613.1
Coordinates 11222..11569 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UQ48_RS22465 7854..8369 + 516 WP_001025395.1 J domain-containing protein -
UQ48_RS22470 8474..9016 + 543 WP_001083906.1 hypothetical protein -
UQ48_RS22475 9013..9264 + 252 WP_001230707.1 hypothetical protein -
UQ48_RS22480 9251..9478 + 228 WP_000801440.1 hypothetical protein -
UQ48_RS22485 9932..10231 + 300 WP_000650309.1 hypothetical protein -
UQ48_RS22490 10322..10672 + 351 WP_063390996.1 hypothetical protein -
UQ48_RS22495 10977..11225 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
UQ48_RS22500 11222..11569 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
UQ48_RS22505 11930..12433 + 504 WP_000781813.1 hypothetical protein -
UQ48_RS22510 12437..13666 + 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
UQ48_RS22515 13743..14036 + 294 WP_000134733.1 LuxR family transcriptional regulator -
UQ48_RS22520 14033..14248 + 216 WP_000760375.1 EexN family lipoprotein -
UQ48_RS22525 14603..15223 + 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
UQ48_RS22530 15291..15563 + 273 WP_001328551.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..32098 32098


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 10656.47 Da        Isoelectric Point: 12.7138

>T53778 WP_000520549.1 NZ_CP011290:10977-11225 [Salmonella enterica subsp. diarizonae]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKK

Download         Length: 249 bp

>T53778 NZ_CP011290:10977-11225 [Salmonella enterica subsp. diarizonae]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 14886.21 Da        Isoelectric Point: 12.8607

>AT53778 WP_000681613.1 NZ_CP011290:11222-11569 [Salmonella enterica subsp. diarizonae]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 348 bp

>AT53778 NZ_CP011290:11222-11569 [Salmonella enterica subsp. diarizonae]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References