Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 9013..9478 Replicon plasmid unnamed1
Accession NZ_CP011290
Organism Salmonella enterica subsp. diarizonae strain 11-01853

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag UQ48_RS22475 Protein ID WP_001230707.1
Coordinates 9013..9264 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag UQ48_RS22480 Protein ID WP_000801440.1
Coordinates 9251..9478 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UQ48_RS22450 4494..5021 - 528 WP_000577043.1 DUF2726 domain-containing protein -
UQ48_RS22455 5156..5560 - 405 WP_012421203.1 hypothetical protein -
UQ48_RS22460 5573..6439 - 867 WP_001353743.1 replication initiation protein -
UQ48_RS22465 7854..8369 + 516 WP_001025395.1 J domain-containing protein -
UQ48_RS22470 8474..9016 + 543 WP_001083906.1 hypothetical protein -
UQ48_RS22475 9013..9264 + 252 WP_001230707.1 hypothetical protein Toxin
UQ48_RS22480 9251..9478 + 228 WP_000801440.1 hypothetical protein Antitoxin
UQ48_RS22485 9932..10231 + 300 WP_000650309.1 hypothetical protein -
UQ48_RS22490 10322..10672 + 351 WP_063390996.1 hypothetical protein -
UQ48_RS22495 10977..11225 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
UQ48_RS22500 11222..11569 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
UQ48_RS22505 11930..12433 + 504 WP_000781813.1 hypothetical protein -
UQ48_RS22510 12437..13666 + 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
UQ48_RS22515 13743..14036 + 294 WP_000134733.1 LuxR family transcriptional regulator -
UQ48_RS22520 14033..14248 + 216 WP_000760375.1 EexN family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..32098 32098


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>T53777 WP_001230707.1 NZ_CP011290:9013-9264 [Salmonella enterica subsp. diarizonae]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>T53777 NZ_CP011290:9013-9264 [Salmonella enterica subsp. diarizonae]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 9759.25 Da        Isoelectric Point: 12.6750

>AT53777 WP_000801440.1 NZ_CP011290:9251-9478 [Salmonella enterica subsp. diarizonae]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 228 bp

>AT53777 NZ_CP011290:9251-9478 [Salmonella enterica subsp. diarizonae]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References