Detailed information of TA system TA053776

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 48234..48768
• Replicon: plasmid unnamed
• Accession: NZ_CP011287
• Organism: Yersinia enterocolitica strain KNG22703

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: XM56_RS20770
• Protein ID: WP_013749473.1
• Coordinates: 48234..48533 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P0C2N3
• Locus tag: XM56_RS20775
• Protein ID: WP_005176524.1
• Coordinates: 48526..48768 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XM56_RS20745	44814..45239	-	426	WP_010891235.1	type III secretion system chaperone SycH	-
XM56_RS22235	45443..46615	-	1173	Protein_55	IS3 family transposase	-
XM56_RS20760	46850..47242	-	393	WP_010891236.1	type III secretion system chaperone SycE/YerA	-
XM56_RS20765	47435..48094	+	660	WP_010891237.1	type III secretion system effector GTPase activator YopE	-
XM56_RS20770	48234..48533	-	300	WP_013749473.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XM56_RS20775	48526..48768	-	243	WP_005176524.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
XM56_RS22240	48934..49226	-	293	Protein_60	IS6 family transposase	-
XM56_RS20780	49606..50571	-	966	WP_010891238.1	ParB/RepB/Spo0J family plasmid partition protein	-
XM56_RS20785	50568..51734	-	1167	WP_010891239.1	plasmid-partitioning protein SopA	-
XM56_RS20795	52350..52820	+	471	WP_010891240.1	hypothetical protein	-
XM56_RS20800	52881..53099	-	219	WP_013749479.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	yopO/ypkA / yopJ/yopP / yopK/yopQ / yopT / sycT / yopM / yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscP / yscQ / yscR / yscS / yscT / yscU / virG/yscW / yscB / yscC / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / sycH / sycE/yerA / yopE / yadA	1..69433	69433
	-	flank	IS/Tn	-	-	45565..46068	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11663.26 Da
• Isoelectric Point: 5.5497

>T53776 WP_013749473.1 NZ_CP011287:c48533-48234 [Yersinia enterocolitica]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNLELGAECNWICSDMRRFQYKKHGIYYITLSNDILI
SRVLHQSIDINAQDFPEYE

Nucleotide

• Length: 300 bp

>T53776 NZ_CP011287:c48533-48234 [Yersinia enterocolitica]
GTGTATAAACTATCTGAACTGGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCTAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGACATGCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAAATGCTCAGGATTTTCCAGAGTATGAGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8856.15 Da
• Isoelectric Point: 6.7232

>AT53776 WP_005176524.1 NZ_CP011287:c48768-48526 [Yersinia enterocolitica]
MARVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNAPVSHRLMDEIFSAAVKDTSV

Nucleotide

• Length: 243 bp

>AT53776 NZ_CP011287:c48768-48526 [Yersinia enterocolitica]
ATGGCTCGCGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAACGCACCTGTGAGCCATCGCTTAATGGATGAAATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Structures

Antitoxin

• AlphaFold DB: A1JUB1