Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3963615..3964150 Replicon chromosome
Accession NZ_CP011286
Organism Yersinia enterocolitica strain KNG22703

Toxin (Protein)


Gene name relE Uniprot ID A0A7U7FI46
Locus tag XM56_RS17665 Protein ID WP_005156226.1
Coordinates 3963615..3963902 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U7FI63
Locus tag XM56_RS17670 Protein ID WP_005156229.1
Coordinates 3963899..3964150 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XM56_RS17635 3958874..3959680 + 807 WP_013649159.1 phosphonate C-P lyase system protein PhnK -
XM56_RS17640 3959694..3960428 + 735 WP_032904377.1 phosphonate C-P lyase system protein PhnL -
XM56_RS17645 3960425..3961573 + 1149 WP_005156213.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
XM56_RS17650 3961573..3962151 + 579 WP_013649157.1 ribose 1,5-bisphosphokinase -
XM56_RS17655 3962142..3962909 + 768 WP_005156220.1 phosphonate metabolism protein PhnP -
XM56_RS17660 3962910..3963539 - 630 WP_005175332.1 hypothetical protein -
XM56_RS17665 3963615..3963902 - 288 WP_005156226.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XM56_RS17670 3963899..3964150 - 252 WP_005156229.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
XM56_RS17675 3964358..3964810 - 453 WP_005181269.1 YhbP family protein -
XM56_RS17680 3964884..3966050 - 1167 WP_013649156.1 alginate lyase family protein -
XM56_RS17685 3966064..3967179 - 1116 WP_032904379.1 ABC transporter ATP-binding protein -
XM56_RS17690 3967191..3968030 - 840 WP_005156238.1 carbohydrate ABC transporter permease -
XM56_RS17695 3968049..3968933 - 885 WP_005156239.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11002.07 Da        Isoelectric Point: 10.3544

>T53774 WP_005156226.1 NZ_CP011286:c3963902-3963615 [Yersinia enterocolitica]
MIYKVKFRSDALKEWGKIDKVIQQQFAKKLKKCCENPHIPSAKLRGLSDCYKIKLRASGFRLVYQVIEDCLVIAVVAVGK
RERSDVYNLASERLR

Download         Length: 288 bp

>T53774 NZ_CP011286:c3963902-3963615 [Yersinia enterocolitica]
ATGATTTATAAAGTAAAATTTAGAAGTGATGCCCTAAAGGAATGGGGAAAGATAGACAAAGTTATTCAACAGCAGTTTGC
TAAAAAACTCAAAAAATGTTGTGAAAATCCTCATATTCCATCAGCAAAATTACGCGGATTATCAGACTGCTATAAAATAA
AATTACGGGCATCTGGTTTTAGGTTAGTTTATCAAGTTATTGAAGATTGTTTAGTTATCGCCGTGGTTGCCGTCGGCAAA
CGCGAACGCAGTGATGTTTATAACCTCGCCAGTGAACGGTTACGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.65 Da        Isoelectric Point: 4.2264

>AT53774 WP_005156229.1 NZ_CP011286:c3964150-3963899 [Yersinia enterocolitica]
MANIILSDTSASVSELKKNPMATVKAGAGYPVAILNRNQPAFYCIPAELYERMLDALDDQELIRLVTERESQPLIDVDLD
KYL

Download         Length: 252 bp

>AT53774 NZ_CP011286:c3964150-3963899 [Yersinia enterocolitica]
ATGGCTAACATAATTTTAAGTGATACGAGCGCAAGTGTCAGCGAGTTAAAGAAAAACCCTATGGCCACAGTCAAAGCGGG
GGCGGGCTATCCAGTGGCTATTTTGAATAGAAACCAACCGGCATTTTATTGTATCCCCGCAGAATTATACGAGAGAATGC
TAGATGCCCTTGATGATCAAGAGCTTATCAGATTAGTTACCGAACGAGAGAGTCAGCCACTCATTGATGTAGATCTGGAT
AAGTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FI46

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FI63

References