Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3927891..3928418 Replicon chromosome
Accession NZ_CP011286
Organism Yersinia enterocolitica strain KNG22703

Toxin (Protein)


Gene name relE Uniprot ID A0A7T9XW08
Locus tag XM56_RS17490 Protein ID WP_005166250.1
Coordinates 3927891..3928166 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7T9XW39
Locus tag XM56_RS17495 Protein ID WP_005166251.1
Coordinates 3928170..3928418 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XM56_RS17460 3923028..3924536 + 1509 WP_005180650.1 IS21-like element ISYen2A family transposase -
XM56_RS17465 3924523..3925248 + 726 WP_013649170.1 IS21-like element ISYen2A/ISYen2B family helper ATPase IstB -
XM56_RS21775 3925544..3926757 - 1214 Protein_3439 IS3 family transposase -
XM56_RS17485 3926984..3927772 - 789 WP_005166249.1 helix-turn-helix domain-containing protein -
XM56_RS17490 3927891..3928166 - 276 WP_005166250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XM56_RS17495 3928170..3928418 - 249 WP_005166251.1 ribbon-helix-helix domain-containing protein Antitoxin
XM56_RS17500 3928495..3928788 - 294 Protein_3443 DUF4942 domain-containing protein -
XM56_RS22435 3928849..3929359 + 511 Protein_3444 helix-turn-helix domain containing protein -
XM56_RS17510 3929656..3930726 - 1071 WP_005166254.1 LPS export ABC transporter permease LptG -
XM56_RS17515 3930726..3931820 - 1095 WP_005166255.1 LPS export ABC transporter permease LptF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10974.31 Da        Isoelectric Point: 4.5486

>T53773 WP_005166250.1 NZ_CP011286:c3928166-3927891 [Yersinia enterocolitica]
MEIYWTLKAQDDLERIYCFALQYSRQHGDDVLDRLITGCAGLTAYPAIGVQQTRYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Download         Length: 276 bp

>T53773 NZ_CP011286:c3928166-3927891 [Yersinia enterocolitica]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGACCTGGAGCGTATCTACTGTTTTGCCCTTCAGTACAGCCGCCAGCA
CGGCGATGACGTTTTGGATCGCCTGATTACAGGCTGTGCTGGTCTTACAGCGTATCCGGCAATTGGCGTACAGCAGACTC
GGTATGAACCTCGGGAAGTCCGAAAAGTGTTATTTGATGATTATGAGGTTCACTACGAACTTCGTGACAATGACATCTAT
ATCGTGGATCTCTGGCATACCAAAGAAGAACGATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9034.30 Da        Isoelectric Point: 6.4624

>AT53773 WP_005166251.1 NZ_CP011286:c3928418-3928170 [Yersinia enterocolitica]
MGSLTKQTISAQIPVELATAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSDMVDFANRLK
QS

Download         Length: 249 bp

>AT53773 NZ_CP011286:c3928418-3928170 [Yersinia enterocolitica]
ATGGGTTCGCTTACTAAACAAACTATCAGCGCACAGATACCTGTTGAGTTGGCTACTGCTGTTGAAAATCTGGCAATTGA
GTTAGATCGTTCTAAAAGTTGGATTATTAAGGAAGCGTTGACCAGTATGCTGGCCGAAAGAGAACGGCGTCACCAGAGCA
TCCAGGCCGGTCTCGCGGATGTGGATGCTGGTCGCGTGGTGAGCCACTCGGACATGGTAGATTTTGCTAATCGCTTAAAG
CAATCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9XW08

Antitoxin

Source ID Structure
AlphaFold DB A0A7T9XW39

References