Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1158984..1159602 Replicon chromosome
Accession NZ_CP011286
Organism Yersinia enterocolitica strain KNG22703

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag XM56_RS05035 Protein ID WP_002208622.1
Coordinates 1158984..1159187 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U7FKE5
Locus tag XM56_RS05040 Protein ID WP_005163463.1
Coordinates 1159234..1159602 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XM56_RS05010 1154355..1154693 + 339 WP_002208627.1 P-II family nitrogen regulator -
XM56_RS05015 1154733..1156022 + 1290 WP_032904831.1 ammonium transporter AmtB -
XM56_RS05020 1156136..1156999 - 864 WP_005163474.1 acyl-CoA thioesterase II -
XM56_RS05025 1157260..1157790 + 531 WP_005163468.1 YbaY family lipoprotein -
XM56_RS05030 1157842..1158147 - 306 WP_005163466.1 MGMT family protein -
XM56_RS05035 1158984..1159187 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
XM56_RS05040 1159234..1159602 - 369 WP_005163463.1 Hha toxicity modulator TomB Antitoxin
XM56_RS05045 1159760..1160113 - 354 WP_005163460.1 hypothetical protein -
XM56_RS05050 1160879..1161589 + 711 WP_013649453.1 ABC transporter ATP-binding protein -
XM56_RS05055 1161603..1162460 + 858 WP_005163445.1 metal ABC transporter permease -
XM56_RS05060 1162523..1163401 + 879 WP_013649455.1 metal ABC transporter substrate-binding protein -
XM56_RS05065 1163529..1163672 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
XM56_RS05070 1163688..1163948 - 261 WP_005163438.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T53760 WP_002208622.1 NZ_CP011286:c1159187-1158984 [Yersinia enterocolitica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T53760 NZ_CP011286:c1159187-1158984 [Yersinia enterocolitica]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14192.90 Da        Isoelectric Point: 4.3377

>AT53760 WP_005163463.1 NZ_CP011286:c1159602-1159234 [Yersinia enterocolitica]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT53760 NZ_CP011286:c1159602-1159234 [Yersinia enterocolitica]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGCAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
PDB 2MN2
AlphaFold DB A0A7U7FKE5

References