Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5241904..5243755 Replicon chromosome
Accession NZ_CP011279
Organism Pandoraea apista strain TF80G25

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag XM39_RS23615 Protein ID WP_052765530.1
Coordinates 5241904..5242812 (+) Length 303 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag XM39_RS23620 Protein ID WP_082117814.1
Coordinates 5242814..5243755 (+) Length 314 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XM39_RS23590 5237323..5238399 + 1077 WP_042118075.1 porin -
XM39_RS23595 5238801..5239574 + 774 WP_082118012.1 ABC transporter ATP-binding protein -
XM39_RS23600 5239613..5240395 + 783 WP_042114934.1 ABC transporter permease -
XM39_RS23605 5240411..5241205 + 795 WP_042114936.1 SDR family oxidoreductase -
XM39_RS23610 5241247..5241804 + 558 WP_042114937.1 cupin domain-containing protein -
XM39_RS23615 5241904..5242812 + 909 WP_052765530.1 alpha/beta fold hydrolase Toxin
XM39_RS23620 5242814..5243755 + 942 WP_082117814.1 IclR family transcriptional regulator Antitoxin
XM39_RS23625 5243752..5244558 + 807 WP_042114938.1 SDR family oxidoreductase -
XM39_RS23630 5244551..5246203 + 1653 WP_042114940.1 thiamine pyrophosphate-binding protein -
XM39_RS23635 5246196..5247014 + 819 WP_042114941.1 aspartate dehydrogenase -
XM39_RS23640 5247028..5248524 + 1497 WP_042114942.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-288)

Antitoxin

Transcription regulator IclR, C-terminal

(168-291)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 31363.44 Da        Isoelectric Point: 5.8839

>T53752 WP_052765530.1 NZ_CP011279:5241904-5242812 [Pandoraea apista]
MQAEASLSEVPEDAAVAPLRARLNAFPYRTLATRTGTVGYRCAGAHAEGGMPVVMLHGIGSGAASWLAQFEATGLNAELY
AWDAPGYGQTSNVADAEPHADAYADALEAWLDALGLKRVALVGHSLGAIMATKFASRSPQRVSGLFLCSPAGGYGKADPD
VRVSKRDSRLAMLDKLGPAGMARERSDNLVAPNAADLPRSWVKWNMARVHPAGYRQATHLLSNGDVAGELAQYVAANAGP
VAVAVGAQDAITTPAACQTIADVAGVPLQIIEGAGHASYIETPDVLNAALAAWLERIAAGER

Download         Length: 909 bp

>T53752 NZ_CP011279:5241904-5242812 [Pandoraea apista]
ATGCAAGCCGAAGCCTCACTGTCCGAAGTGCCCGAAGATGCCGCCGTCGCACCGCTGCGCGCGCGTCTGAATGCTTTCCC
GTACCGCACGCTCGCCACGCGTACGGGCACCGTCGGCTATCGCTGCGCTGGCGCGCATGCCGAGGGTGGCATGCCGGTCG
TGATGCTGCACGGCATTGGGTCCGGCGCGGCGTCATGGCTGGCGCAGTTCGAAGCCACAGGGCTTAACGCCGAGCTTTAC
GCGTGGGACGCCCCGGGCTATGGGCAGACGTCGAACGTCGCCGATGCCGAGCCGCATGCCGATGCTTACGCCGACGCGCT
TGAGGCGTGGCTCGATGCCCTGGGGCTCAAGCGTGTCGCTCTCGTTGGCCACTCGCTGGGCGCGATCATGGCGACGAAGT
TTGCGAGCCGCTCCCCGCAGCGTGTGAGTGGACTCTTTCTCTGCTCGCCGGCCGGCGGTTACGGCAAGGCCGATCCGGAC
GTGCGCGTAAGCAAGCGCGATAGCCGTCTGGCGATGCTCGACAAGCTGGGCCCGGCCGGCATGGCCCGCGAGCGCAGCGA
CAATCTCGTCGCGCCGAATGCCGCAGACCTGCCGCGCTCCTGGGTGAAATGGAACATGGCGCGCGTGCATCCCGCCGGAT
ACCGGCAGGCGACGCACCTTCTCTCGAACGGCGACGTCGCCGGCGAGTTGGCGCAATACGTGGCCGCGAACGCCGGGCCG
GTGGCCGTGGCGGTCGGCGCACAGGATGCGATCACGACGCCCGCAGCTTGCCAGACGATTGCCGACGTGGCCGGCGTGCC
ACTGCAGATCATCGAAGGCGCGGGACACGCGTCGTACATCGAAACCCCGGACGTTCTGAACGCCGCGCTCGCGGCGTGGC
TCGAGCGCATCGCGGCAGGAGAGCGCTGA

Antitoxin


Download         Length: 314 a.a.        Molecular weight: 34121.88 Da        Isoelectric Point: 6.3621

>AT53752 WP_082117814.1 NZ_CP011279:5242814-5243755 [Pandoraea apista]
MAPATPKRAAAAPDAQIEDDKLGLQDTQTDGDELAEGSTSDTRYLVPGLERGLRILTQFSPREAVFSAPELSQRLGIPRT
TVFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQS
VAGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLAELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFER
GISVVSAPVRNDAGRICAAITVTIPRANIDSSMLDAGLIGQVREAADALSHRLNYRPGSDRQPTPYMKSLGLK

Download         Length: 942 bp

>AT53752 NZ_CP011279:5242814-5243755 [Pandoraea apista]
ATGGCACCGGCAACCCCGAAGCGCGCAGCGGCAGCGCCCGACGCGCAGATCGAAGACGACAAGCTCGGTCTTCAGGACAC
CCAGACCGATGGCGACGAACTCGCCGAAGGTTCAACGTCCGACACCCGTTATCTCGTGCCCGGTCTGGAGCGCGGCTTGC
GCATTCTTACGCAGTTCTCGCCGCGCGAGGCCGTATTCAGCGCGCCGGAGTTGTCGCAACGCCTCGGCATTCCGCGTACC
ACCGTTTTCCGTTTGTTGCAGACGCTTGAAGCGATGGGTTTTCTGGAGCGCGCGGGGAGCGAGAAGAATTTCCGTCTGGG
CGTGGCAGTGCTGCGTCTGGGCTTCGAATACCTCAGTTCGCTGGAGTTGACCGATCTGGGGATTCCGATCATCGAACGGC
TGCGCGACGCCACGCAATTGACCTCGCACATCGTGATCCGGGACGGGCGAGACATCGTGTTCGTGGCGAAGGCGCAAAGC
GTTGCCGGCGTTTTCAATTCGATCAAGGTAAACGTCGGCACGCGTCTGCCGGCGCATGCAACGGTGCATGGCCATGTGCT
GATGGGCGACCTGACGCTGGCCGAGCTTCGTGCGCTGTATCCGGAAAAGACGCTAGAAAAATACACGCCGCAAACGCCCG
AGACGCTTGCGGAGTTGTTCGAACGGGTGCGTGAAGACGCCGAGCGCGGTTACGCGGTGTCGGCTTCGTCGTTCGAGCGG
GGCATCAGTGTCGTGAGTGCACCGGTGCGCAACGACGCGGGCCGTATCTGCGCCGCCATCACCGTGACCATTCCGCGCGC
CAACATCGATTCGTCAATGCTCGATGCGGGGCTGATCGGACAGGTGCGCGAGGCGGCCGATGCGCTGTCGCATCGTCTGA
ACTATCGACCGGGCAGCGACCGTCAACCCACCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References