Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-ChpS
Location 5693160..5693746 Replicon chromosome
Accession NZ_CP011273
Organism Planctomyces sp. SH-PL62

Toxin (Protein)


Gene name pemK Uniprot ID A0A142YM51
Locus tag VT85_RS22290 Protein ID WP_068420149.1
Coordinates 5693417..5693746 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A142YLY4
Locus tag VT85_RS22285 Protein ID WP_068420147.1
Coordinates 5693160..5693417 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VT85_RS27015 5689338..5689616 + 279 WP_082858798.1 hypothetical protein -
VT85_RS22270 5689616..5690122 + 507 WP_068420141.1 Dna2/Cas4 domain-containing protein -
VT85_RS27020 5690173..5691249 - 1077 WP_082858799.1 DUF4062 domain-containing protein -
VT85_RS27920 5691255..5691812 - 558 WP_156513027.1 hypothetical protein -
VT85_RS27025 5692221..5692514 - 294 WP_082858800.1 abortive infection family protein -
VT85_RS22280 5692607..5692900 - 294 WP_068420145.1 WGR domain-containing protein -
VT85_RS22285 5693160..5693417 + 258 WP_068420147.1 antitoxin Antitoxin
VT85_RS22290 5693417..5693746 + 330 WP_068420149.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
VT85_RS22295 5693913..5694482 + 570 WP_068420151.1 recombinase family protein -
VT85_RS27925 5694752..5695507 - 756 WP_197490935.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
VT85_RS27930 5695628..5696032 + 405 WP_156513029.1 hypothetical protein -
VT85_RS27030 5696349..5697254 + 906 WP_082858801.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
VT85_RS27035 5697769..5698638 - 870 WP_082858802.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5664947..5814439 149492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12110.06 Da        Isoelectric Point: 9.2420

>T53749 WP_068420149.1 NZ_CP011273:5693417-5693746 [Planctomyces sp. SH-PL62]
MQRGDIYHVDLNPVQGREQLGRRYVLVVSRREFNQFGTPLVCPITQGGEFARSKGFAVPLSGATVNVHGVVLCHQPRTLD
LQARKATFVEKAPPAIVEEVIARLMTLLE

Download         Length: 330 bp

>T53749 NZ_CP011273:5693417-5693746 [Planctomyces sp. SH-PL62]
ATGCAGCGGGGGGATATTTACCACGTCGATCTCAATCCGGTGCAGGGGAGGGAGCAGCTTGGGCGGCGCTATGTGCTGGT
GGTATCACGGCGGGAGTTCAACCAGTTCGGCACGCCGCTGGTCTGCCCGATCACGCAGGGCGGCGAGTTTGCCCGGAGTA
AAGGCTTCGCCGTACCCTTAAGCGGTGCCACGGTCAACGTGCATGGTGTTGTGCTTTGCCATCAGCCCCGCACGCTTGAT
CTCCAGGCCCGCAAAGCCACCTTCGTAGAAAAGGCACCGCCTGCCATCGTCGAGGAGGTGATTGCCCGGTTGATGACACT
GCTGGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9089.47 Da        Isoelectric Point: 4.3297

>AT53749 WP_068420147.1 NZ_CP011273:5693160-5693417 [Planctomyces sp. SH-PL62]
MHYSTLRTVGGSVMFAIPKPVLDMLGLRPNAEVGITVADGRLIVDPQAKPRYTLEELIGQCDLAAPLTKEEQAWLDDGPA
GGEAI

Download         Length: 258 bp

>AT53749 NZ_CP011273:5693160-5693417 [Planctomyces sp. SH-PL62]
ATGCACTACTCAACTCTTCGCACCGTCGGCGGATCAGTGATGTTCGCCATCCCCAAGCCGGTGCTTGACATGCTTGGCCT
GCGTCCCAATGCCGAAGTGGGCATTACCGTGGCCGATGGGCGGCTGATCGTCGATCCGCAGGCCAAACCCCGGTACACGC
TGGAGGAGCTGATTGGGCAATGCGACCTGGCGGCCCCTCTGACAAAAGAGGAACAAGCCTGGCTGGACGATGGCCCTGCT
GGCGGCGAAGCCATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142YM51

Antitoxin

Source ID Structure
AlphaFold DB A0A142YLY4

References