Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3284667..3285672 Replicon chromosome
Accession NZ_CP011269
Organism Mycolicibacterium fortuitum strain CT6

Toxin (Protein)


Gene name pezT Uniprot ID A0A0N9Y6Z9
Locus tag XA26_RS15690 Protein ID WP_054602347.1
Coordinates 3285094..3285672 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID K0VQA4
Locus tag XA26_RS15685 Protein ID WP_003884795.1
Coordinates 3284667..3285056 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XA26_RS15665 3280676..3281224 - 549 WP_054604138.1 GNAT family N-acetyltransferase -
XA26_RS15670 3281256..3281666 - 411 WP_003884798.1 transglycosylase family protein -
XA26_RS15675 3282061..3283419 - 1359 WP_054602345.1 LysM peptidoglycan-binding domain-containing protein -
XA26_RS15680 3283583..3284605 + 1023 WP_054602346.1 TIGR03617 family F420-dependent LLM class oxidoreductase -
XA26_RS15685 3284667..3285056 + 390 WP_003884795.1 hypothetical protein Antitoxin
XA26_RS15690 3285094..3285672 + 579 WP_054602347.1 zeta toxin family protein Toxin
XA26_RS30350 3285633..3286136 + 504 WP_081015581.1 hypothetical protein -
XA26_RS15695 3286156..3286791 - 636 WP_054602348.1 histidine phosphatase family protein -
XA26_RS15700 3286827..3287183 - 357 WP_003884792.1 hypothetical protein -
XA26_RS15705 3287194..3287919 - 726 WP_003884791.1 thiocyanate hydrolase subunit gamma -
XA26_RS15710 3287954..3288778 - 825 WP_054602349.1 nitrile hydratase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-138)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 20993.07 Da        Isoelectric Point: 9.0672

>T53747 WP_054602347.1 NZ_CP011269:3285094-3285672 [Mycolicibacterium fortuitum]
VKRLDLVVGCNGAGKSTFVELTLSPLLPGSPFVNADEIAKHRWPQDPASHSYEAALVAAETRAKLIQLGESFIAETVFSH
PSKLELIDDARAAGYTLILHCLLIPEELAVQRVRHRVRAGGHHVPEKKIRERYQRLWNLVAIAAVRVDSATFYDNSAVSG
PRIVAQIAGGFVVGSPTWPTWTPTALSSRWPG

Download         Length: 579 bp

>T53747 NZ_CP011269:3285094-3285672 [Mycolicibacterium fortuitum]
GTGAAGCGTCTCGATCTCGTCGTCGGGTGCAACGGCGCCGGCAAGTCCACCTTCGTCGAGCTCACCCTCTCTCCACTGCT
CCCTGGCAGCCCGTTCGTCAACGCGGATGAAATCGCCAAACATCGCTGGCCGCAAGACCCCGCGTCCCACTCGTACGAAG
CCGCGCTCGTGGCCGCAGAAACCCGTGCCAAACTCATTCAGCTCGGAGAATCCTTCATCGCCGAGACCGTGTTTTCGCAC
CCCTCCAAACTCGAGCTCATCGACGACGCACGGGCCGCTGGATACACCCTGATCCTGCACTGCCTCCTGATCCCCGAAGA
GCTGGCCGTACAGCGAGTGCGCCACCGCGTTCGCGCCGGCGGGCATCACGTGCCCGAGAAGAAAATTCGGGAACGCTACC
AACGGCTTTGGAACCTCGTCGCAATCGCGGCGGTCCGGGTCGACTCGGCAACGTTCTACGACAACAGCGCCGTTTCAGGC
CCGCGGATCGTCGCCCAGATCGCCGGCGGGTTCGTCGTGGGATCGCCTACCTGGCCGACATGGACACCAACAGCACTGAG
TTCCCGCTGGCCTGGATAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13567.00 Da        Isoelectric Point: 4.5256

>AT53747 WP_003884795.1 NZ_CP011269:3284667-3285056 [Mycolicibacterium fortuitum]
MTETADRVTRFAADLIDSAAAEGARQSRSAKQQLDHWARVGRAVSSRHSAARRKVEAALAGDIALGELTAEEGAVFDAEI
AASIEESLARTDYGKALAARGITTVALDEDGEIVQYLPDGSTAVLAPQQ

Download         Length: 390 bp

>AT53747 NZ_CP011269:3284667-3285056 [Mycolicibacterium fortuitum]
ATGACGGAGACCGCAGATCGTGTGACCCGGTTCGCCGCTGACCTCATCGACAGTGCTGCCGCGGAAGGTGCACGTCAGAG
CCGGTCGGCCAAGCAGCAGCTCGACCATTGGGCCCGCGTGGGCCGCGCTGTGTCCAGCCGGCACAGCGCCGCCCGCCGAA
AGGTAGAGGCCGCCCTGGCCGGCGACATTGCGCTCGGCGAATTGACCGCCGAGGAAGGCGCGGTATTCGACGCCGAGATC
GCCGCATCAATCGAGGAAAGCCTGGCCCGCACCGACTACGGCAAGGCACTGGCCGCCCGTGGTATCACCACCGTTGCGCT
GGACGAGGACGGCGAGATCGTGCAGTACCTGCCCGACGGCAGCACCGCGGTGTTGGCGCCGCAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N9Y6Z9

Antitoxin

Source ID Structure
AlphaFold DB K0VQA4

References