Detailed information of TA system TA053746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1283480..1284112
• Replicon: chromosome
• Accession: NZ_CP011269
• Organism: Mycolicibacterium fortuitum strain CT6

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: XA26_RS05980
• Protein ID: WP_003881879.1
• Coordinates: 1283663..1284112 (+)
• Length: 150 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: A0A100WWS2
• Locus tag: XA26_RS05975
• Protein ID: WP_054601330.1
• Coordinates: 1283480..1283659 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XA26_RS05960	1279019..1279753	+	735	WP_054601327.1	enoyl-CoA hydratase	-
XA26_RS05965	1279755..1280861	+	1107	WP_054601328.1	MBL fold metallo-hydrolase	-
XA26_RS05970	1280928..1283420	+	2493	WP_054601329.1	cation-translocating P-type ATPase	-
XA26_RS05975	1283480..1283659	+	180	WP_054601330.1	antitoxin	Antitoxin
XA26_RS05980	1283663..1284112	+	450	WP_003881879.1	SRPBCC family protein	Toxin
XA26_RS05985	1284153..1284722	-	570	WP_054601331.1	isomerase	-
XA26_RS05990	1284719..1285936	-	1218	WP_054601332.1	cytochrome P450	-
XA26_RS05995	1285929..1286342	-	414	WP_054601333.1	hypothetical protein	-
XA26_RS06000	1286339..1287397	-	1059	WP_054601334.1	dihydrodipicolinate reductase	-
XA26_RS06005	1287390..1288439	-	1050	WP_054601335.1	dihydrodipicolinate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-145)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 150 a.a.
• Molecular weight: 16117.67 Da
• Isoelectric Point: 9.6573

>T53746 WP_003881879.1 NZ_CP011269:1283663-1284112 [Mycolicibacterium fortuitum]
MAKLSVSVEVPLPPEKAWEYASDLSRYDEWLSIHRAWRSKLPETLEKGTVIDSIVEVKGMLNRVKWTLVNYKPPQSLTLN
GDGRGGVKVKLIGKITPAAVDGGDGAKVSFDVHLGGPALFGPIGMVVAAALKGDIQQSLNKFKELYASS

Nucleotide

• Length: 450 bp

>T53746 NZ_CP011269:1283663-1284112 [Mycolicibacterium fortuitum]
ATGGCCAAATTGTCTGTCTCCGTCGAAGTTCCGTTGCCGCCGGAGAAGGCGTGGGAGTACGCCTCAGATCTGTCCCGGTA
CGACGAGTGGCTCAGCATCCACCGGGCCTGGCGGTCGAAGTTGCCCGAAACCCTGGAAAAGGGCACGGTGATCGACTCGA
TCGTCGAGGTCAAGGGCATGTTGAACCGTGTGAAGTGGACGCTGGTGAACTACAAGCCGCCGCAGTCGTTGACCCTCAAC
GGCGACGGTCGTGGCGGGGTGAAGGTCAAGCTGATCGGAAAGATCACGCCGGCCGCCGTTGACGGTGGAGACGGTGCGAA
GGTCTCTTTCGACGTGCATCTGGGTGGGCCCGCGCTGTTCGGGCCGATCGGCATGGTGGTCGCCGCCGCGCTCAAGGGCG
ATATCCAGCAGTCGCTGAACAAGTTCAAGGAGCTCTACGCGTCGTCGTAG

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6406.10 Da
• Isoelectric Point: 4.5045

>AT53746 WP_054601330.1 NZ_CP011269:1283480-1283659 [Mycolicibacterium fortuitum]
MGFLDKAKDLLSQNADKVEQAIEKAGDIVDEKTQGKYSGAVDKAQEAAKNAINKEEPQQ

Nucleotide

• Length: 180 bp

>AT53746 NZ_CP011269:1283480-1283659 [Mycolicibacterium fortuitum]
ATGGGATTCCTGGACAAGGCCAAGGACCTTTTGTCGCAGAACGCCGACAAGGTCGAGCAGGCCATCGAGAAGGCCGGCGA
CATCGTCGACGAGAAGACTCAGGGCAAGTACTCGGGCGCGGTCGACAAGGCACAGGAAGCGGCGAAGAACGCCATCAACA
AGGAAGAACCGCAGCAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A100WWS2