Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1174197..1175943 Replicon chromosome
Accession NZ_CP011258
Organism Ralstonia mannitolilytica strain SN83A39

Toxin (Protein)


Gene name doc Uniprot ID A0A160C095
Locus tag VZ52_RS21280 Protein ID WP_063394579.1
Coordinates 1175038..1175943 (-) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A160C040
Locus tag VZ52_RS21275 Protein ID WP_063394578.1
Coordinates 1174197..1175024 (-) Length 276 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VZ52_RS21255 1169345..1170826 - 1482 WP_063394574.1 aldehyde dehydrogenase -
VZ52_RS21260 1170835..1171638 - 804 WP_063394575.1 aspartate dehydrogenase -
VZ52_RS21265 1171671..1173398 - 1728 WP_063394576.1 thiamine pyrophosphate-binding protein -
VZ52_RS21270 1173391..1174194 - 804 WP_063394577.1 SDR family oxidoreductase -
VZ52_RS21275 1174197..1175024 - 828 WP_063394578.1 IclR family transcriptional regulator Antitoxin
VZ52_RS21280 1175038..1175943 - 906 WP_063394579.1 alpha/beta hydrolase Toxin
VZ52_RS21285 1175948..1176484 - 537 WP_063394580.1 cupin domain-containing protein -
VZ52_RS21290 1176535..1177308 - 774 WP_063394581.1 SDR family oxidoreductase -
VZ52_RS21295 1177301..1178368 - 1068 WP_063394582.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
VZ52_RS21300 1178450..1178752 - 303 WP_063394583.1 hypothetical protein -
VZ52_RS21305 1178974..1179435 - 462 WP_063394584.1 GNAT family N-acetyltransferase -
VZ52_RS21310 1179758..1179997 - 240 WP_063394585.1 DUF2798 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(52-288)

Antitoxin

Transcription regulator IclR, C-terminal

(137-258)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 31975.11 Da        Isoelectric Point: 6.8316

>T53741 WP_063394579.1 NZ_CP011258:c1175943-1175038 [Ralstonia mannitolilytica]
MSAQAVMSSRPFRVADALAVLEAEFAERTVTINAQGDRIGYRQWGGRGPVAVLLHGISSSAASWLPCAQVLSQTMRVFAW
DAPGYGRSTPLEQAEPRAADYAQRLQAWLGALQVKPDVIVGHSLGALMAAAYMAHAPEALQPGCVLLLNPAQGYGQPGHE
DQSRSVRAQRLATLDRLGIEGMAESRHAHLLRPDAGSEARAWVRWNMLRLNDGGYRQAVAMLSGDDIGGYLRKRAASTPA
RVACGDVDGITPPQGCEALADAFGLPFARVADAGHASYIDAPDAVAGWIAQAAFSSSQNAY

Download         Length: 906 bp

>T53741 NZ_CP011258:c1175943-1175038 [Ralstonia mannitolilytica]
ATGAGCGCGCAGGCTGTCATGTCTTCCCGTCCGTTTCGCGTGGCCGATGCACTGGCCGTGCTCGAGGCCGAGTTTGCCGA
ACGCACCGTCACGATCAACGCCCAGGGCGATCGCATCGGCTATCGGCAGTGGGGCGGTCGCGGGCCGGTGGCGGTGCTGT
TGCACGGCATCAGCTCCAGCGCCGCGTCGTGGCTGCCTTGCGCGCAGGTTCTCTCGCAAACCATGCGCGTGTTCGCGTGG
GATGCGCCGGGCTATGGCCGATCCACGCCGCTCGAACAAGCCGAGCCGCGCGCTGCCGATTACGCGCAGCGCTTGCAGGC
ATGGCTGGGCGCGCTGCAGGTGAAGCCGGACGTGATCGTCGGACATTCGCTGGGCGCGCTGATGGCTGCGGCCTATATGG
CCCACGCGCCGGAAGCGCTGCAACCCGGCTGCGTGCTGCTGCTGAACCCCGCGCAGGGTTACGGGCAGCCCGGTCACGAA
GACCAGTCCCGCAGTGTGCGGGCCCAGCGCCTTGCCACGCTCGACCGGCTTGGCATCGAGGGCATGGCGGAATCGCGCCA
CGCGCATCTGCTGCGCCCGGATGCCGGCAGCGAAGCGCGCGCCTGGGTGCGCTGGAACATGCTGCGCCTGAACGACGGCG
GTTACCGCCAGGCCGTGGCCATGCTCAGCGGCGACGACATCGGCGGGTATCTGCGCAAGCGCGCGGCTTCAACGCCGGCC
CGCGTGGCCTGTGGCGATGTCGACGGCATCACGCCGCCGCAGGGCTGCGAAGCGTTGGCCGACGCCTTCGGCCTGCCTTT
CGCGCGGGTGGCCGACGCCGGGCACGCGTCGTACATCGATGCGCCGGATGCCGTTGCCGGCTGGATTGCACAAGCCGCTT
TCTCCTCATCCCAAAACGCCTACTAA

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30598.33 Da        Isoelectric Point: 5.4605

>AT53741 WP_063394578.1 NZ_CP011258:c1175024-1174197 [Ralstonia mannitolilytica]
MSNDLIPEDVQEKYIVPGLERGLRLLCEFSHKDRVLSAPELARRLKVPRSTVFRLLTTLEVMGFIERVDGGRDFRLGMAV
LRLGFEYLASLELTELGRPLLDRLRDDIHYPCNLVVRDGRSIVYVAKSVAPTPFTSSVNVGTRLPAHATVLGRVLLADLS
LAELRQLYPEPQLEAFTANTPRTVEDLFEMVQRDREHGYVLEEGFFEANISTIAAPVLDRAGKIVAALGTTIPSPRIDPA
QLDPMIDKVRAAAGELSYLLDYRPASGKVVNLFGE

Download         Length: 828 bp

>AT53741 NZ_CP011258:c1175024-1174197 [Ralstonia mannitolilytica]
ATGAGCAACGACCTCATTCCCGAAGACGTGCAGGAAAAGTACATCGTGCCCGGGCTCGAACGCGGCCTGCGCCTGCTGTG
CGAGTTCAGCCACAAAGACCGCGTGCTGTCTGCGCCGGAACTGGCGCGCCGGCTGAAGGTGCCGCGCTCCACGGTGTTCC
GCCTGCTGACCACGCTCGAGGTGATGGGCTTCATCGAGCGCGTGGACGGCGGCCGGGATTTCCGCCTCGGCATGGCCGTG
CTGCGCCTCGGGTTCGAGTATCTCGCCTCGCTCGAGTTGACCGAACTCGGCCGTCCGCTGCTCGACCGCCTGCGCGACGA
CATTCACTATCCGTGCAACCTCGTCGTGCGCGATGGCCGCTCGATCGTCTACGTGGCGAAATCGGTGGCGCCGACGCCGT
TCACGAGCTCGGTCAACGTCGGTACGCGCCTGCCCGCGCATGCCACGGTGCTGGGGCGCGTGCTGCTGGCCGACCTGTCG
CTGGCCGAGCTGCGTCAGCTGTATCCGGAGCCTCAGCTGGAGGCATTCACCGCCAACACGCCGCGCACCGTGGAAGACCT
GTTCGAGATGGTGCAGCGCGACCGCGAACACGGCTACGTGCTCGAAGAGGGCTTCTTCGAGGCGAACATCTCGACGATCG
CGGCGCCGGTGCTCGACCGCGCCGGCAAGATCGTCGCCGCGCTCGGCACGACGATCCCGTCGCCGCGCATCGACCCCGCG
CAGCTCGATCCCATGATCGACAAGGTGCGCGCTGCCGCAGGCGAGCTCTCTTACCTGCTCGACTACCGCCCGGCCAGCGG
CAAGGTCGTCAACCTGTTCGGGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A160C095

Antitoxin

Source ID Structure
AlphaFold DB A0A160C040

References