Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2728487..2729280 Replicon chromosome
Accession NZ_CP011257
Organism Ralstonia mannitolilytica strain SN83A39

Toxin (Protein)


Gene name tacT Uniprot ID A0A160BUT4
Locus tag VZ52_RS12980 Protein ID WP_019562035.1
Coordinates 2728487..2728990 (-) Length 168 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A166KQ83
Locus tag VZ52_RS12985 Protein ID WP_019562034.1
Coordinates 2728987..2729280 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VZ52_RS12955 2724304..2725197 + 894 WP_156509297.1 hypothetical protein -
VZ52_RS23260 2725209..2725583 + 375 WP_156509264.1 hypothetical protein -
VZ52_RS12960 2725725..2726168 + 444 WP_019562039.1 hypothetical protein -
VZ52_RS12965 2726230..2726691 + 462 WP_019562038.1 DUF2924 domain-containing protein -
VZ52_RS12970 2726688..2728028 + 1341 WP_028769420.1 recombinase family protein -
VZ52_RS12975 2728025..2728477 + 453 WP_028769421.1 hypothetical protein -
VZ52_RS12980 2728487..2728990 - 504 WP_019562035.1 GNAT family N-acetyltransferase Toxin
VZ52_RS12985 2728987..2729280 - 294 WP_019562034.1 DUF1778 domain-containing protein Antitoxin
VZ52_RS12995 2729978..2733736 - 3759 WP_063393041.1 DUF748 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-90)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 18452.30 Da        Isoelectric Point: 10.5864

>T53739 WP_019562035.1 NZ_CP011257:c2728990-2728487 [Ralstonia mannitolilytica]
VTLRAPAPLAAQHRLEGFDCGKPALNDWLLRHARQAQGSGSAKTFVVAADGDDRVAGYFSLTVGQVDTLEAPERIRKGMG
QYPVPVVILARLAVSREHQGRGIGIGMLQDAIRRTLVIAEQAGVRAMLTHPIDEDATRFYTRFGFIASPLREQQLLLLLK
DARRWVR

Download         Length: 504 bp

>T53739 NZ_CP011257:c2728990-2728487 [Ralstonia mannitolilytica]
GTGACGCTGCGGGCACCGGCGCCTCTGGCCGCACAGCATCGGCTGGAAGGCTTCGACTGCGGCAAGCCTGCGCTGAACGA
TTGGCTGCTGCGCCACGCCCGCCAGGCGCAGGGCAGTGGCTCGGCCAAGACCTTCGTCGTGGCCGCCGATGGTGACGACC
GCGTCGCAGGCTACTTCAGCCTGACCGTAGGCCAGGTCGACACGCTGGAAGCGCCGGAGCGTATCCGCAAGGGCATGGGA
CAGTACCCGGTGCCGGTGGTGATCTTGGCCCGGCTCGCCGTGTCACGCGAGCACCAGGGCCGCGGGATCGGCATCGGGAT
GCTTCAGGATGCGATCCGCCGCACGCTGGTGATCGCCGAGCAGGCCGGTGTGCGGGCCATGCTGACCCATCCGATTGATG
AAGACGCGACCAGGTTCTACACCCGATTTGGGTTCATCGCCTCGCCGCTGCGCGAGCAGCAGTTGCTACTGCTCTTGAAG
GACGCCCGTCGCTGGGTTCGTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10590.07 Da        Isoelectric Point: 5.0914

>AT53739 WP_019562034.1 NZ_CP011257:c2729280-2728987 [Ralstonia mannitolilytica]
MTAIASSPAARTARLGLRATPEQEAVLRRAAEVAHKSLTDFILDSACLAAEQTLLDQRLFMVSGSQYQALMELLERSEQA
NDGLADLFARKAPWDAK

Download         Length: 294 bp

>AT53739 NZ_CP011257:c2729280-2728987 [Ralstonia mannitolilytica]
ATGACCGCCATCGCATCCTCGCCTGCTGCCCGTACTGCCCGCCTGGGGCTGCGCGCCACGCCCGAACAGGAGGCCGTGCT
GCGCCGTGCCGCCGAGGTGGCCCACAAGTCGCTGACCGACTTCATCCTCGACAGCGCCTGCCTGGCCGCCGAGCAGACCC
TGCTGGACCAACGATTGTTCATGGTCTCGGGCAGCCAGTACCAGGCCCTGATGGAGTTGCTCGAGCGCTCCGAGCAGGCC
AACGACGGCTTGGCCGACCTGTTCGCCCGCAAGGCCCCTTGGGACGCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A160BUT4

Antitoxin

Source ID Structure
AlphaFold DB A0A166KQ83

References