Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5363027..5363656 Replicon chromosome
Accession NZ_CP011254
Organism Serratia fonticola strain DSM 4576

Toxin (Protein)


Gene name hicA Uniprot ID A0A0F7HGI5
Locus tag WN53_RS23780 Protein ID WP_021805694.1
Coordinates 5363027..5363215 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0F7D356
Locus tag WN53_RS23785 Protein ID WP_024485643.1
Coordinates 5363243..5363656 (+) Length 138 a.a.

Genomic Context

WN53_RS23775WN53_RS23780WN53_RS23785WN53_RS23770WN53_RS23790WN53_RS23795WN53_RS23800WN53_RS23805WN53_RS23810WN53_RS23815
Location: 5361902..5362837 (936 bp)
Type: Others
Protein ID: WP_024485642.1
Location: 5363027..5363215 (189 bp)
Type: Toxin
Protein ID: WP_021805694.1
Location: 5363243..5363656 (414 bp)
Type: Antitoxin
Protein ID: WP_024485643.1
Location: 5361064..5361693 (630 bp)
Type: Others
Protein ID: WP_024485641.1
Location: 5363689..5364441 (753 bp)
Type: Others
Protein ID: WP_021805696.1
Location: 5364445..5365107 (663 bp)
Type: Others
Protein ID: WP_021180972.1
Location: 5365107..5365907 (801 bp)
Type: Others
Protein ID: WP_024485644.1
Location: 5366026..5367012 (987 bp)
Type: Others
Protein ID: WP_046808332.1
Location: 5367207..5367716 (510 bp)
Type: Others
Protein ID: WP_024486813.1
Location: 5367777..5368499 (723 bp)
Type: Others
Protein ID: WP_021180968.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
WN53_RS237705361064..5361693-630WP_024485641.1TetR/AcrR family transcriptional regulator-
WN53_RS237755361902..5362837+936WP_024485642.1nitronate monooxygenase-
WN53_RS237805363027..5363215+189WP_021805694.1type II toxin-antitoxin system HicA family toxinToxin
WN53_RS237855363243..5363656+414WP_024485643.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
WN53_RS237905363689..5364441-753WP_021805696.1L-cystine ABC transporter ATP-binding protein YecC-
WN53_RS237955364445..5365107-663WP_021180972.1cystine ABC transporter permease-
WN53_RS238005365107..5365907-801WP_024485644.1cystine ABC transporter substrate-binding protein-
WN53_RS238055366026..5367012-987WP_046808332.1D-cysteine desulfhydrase-
WN53_RS238105367207..5367716-510WP_024486813.1flagella biosynthesis regulatory protein FliZ-
WN53_RS238155367777..5368499-723WP_021180968.1RNA polymerase sigma factor FliA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage-fliZ / fliA5350023..536849918476


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7005.17 Da        Isoelectric Point: 11.1589

>T53734 WP_021805694.1 NZ_CP011254:5363027-5363215 [Serratia fonticola]
VKSSELIKRLESHGWVLQRIKGSHHQFKHPNSSLVITVPHPNKDVKLGTLRQIMKDAGLLNS

Download         Length: 189 bp

>T53734 NZ_CP011254:5363027-5363215 [Serratia fonticola]
GTGAAAAGTTCAGAACTGATTAAACGACTCGAAAGCCATGGTTGGGTTTTACAACGGATCAAAGGCAGCCACCATCAATT
CAAACACCCTAACTCATCGTTGGTGATCACCGTGCCTCATCCCAATAAGGATGTGAAATTGGGAACGCTGCGGCAAATCA
TGAAGGATGCAGGGCTGCTTAATTCCTAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15031.77 Da        Isoelectric Point: 4.8403

>AT53734 WP_024485643.1 NZ_CP011254:5363243-5363656 [Serratia fonticola]
MFYPAYIHAEPDGSASGFFPDVPGCYFAGDSLDQTFQDAKSALDAHFELLSEENQAIPRPQTVSFHLAQGNDALNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDALVQQHPGYGSRSAFLAAAARNELLKAG

Download         Length: 414 bp

>AT53734 NZ_CP011254:5363243-5363656 [Serratia fonticola]
ATGTTTTATCCCGCTTATATACATGCCGAGCCGGATGGCAGCGCCAGCGGCTTCTTTCCCGATGTGCCAGGCTGCTACTT
TGCCGGAGACAGTCTCGATCAAACCTTCCAGGATGCCAAAAGCGCTCTGGATGCCCACTTTGAATTATTGAGCGAAGAGA
ATCAGGCCATTCCACGCCCACAAACAGTGTCCTTCCATCTGGCTCAGGGCAACGACGCCCTCAACGGCGGGCAGTGGCTG
CTGGTGGATATCAATATGGACAAGTTCGATGGCCGGGCAGAACGCATCAATATCACGTTGCCCCACAGGCTGCTCAACCG
CATTGATGCGCTGGTGCAGCAGCATCCGGGCTATGGCAGCCGCAGCGCATTTCTCGCCGCCGCAGCGCGTAATGAGTTGT
TAAAGGCAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F7HGI5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F7D356

References