Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3361363..3362043 Replicon chromosome
Accession NZ_CP011254
Organism Serratia fonticola strain DSM 4576

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0F7HCV0
Locus tag WN53_RS14900 Protein ID WP_024484798.1
Coordinates 3361723..3362043 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0F7HBS3
Locus tag WN53_RS14895 Protein ID WP_024484797.1
Coordinates 3361363..3361686 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WN53_RS14865 3356862..3357737 + 876 WP_046808094.1 GTPase family protein -
WN53_RS14870 3357950..3358651 + 702 WP_024484792.1 WYL domain-containing protein -
WN53_RS14875 3358657..3359289 + 633 WP_024484793.1 hypothetical protein -
WN53_RS14880 3359457..3359867 + 411 WP_158645299.1 hypothetical protein -
WN53_RS14885 3359989..3360810 + 822 WP_024484795.1 DUF945 domain-containing protein -
WN53_RS14890 3360880..3361350 + 471 WP_024484796.1 DNA repair protein RadC -
WN53_RS14895 3361363..3361686 + 324 WP_024484797.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
WN53_RS14900 3361723..3362043 + 321 WP_024484798.1 TA system toxin CbtA family protein Toxin
WN53_RS14905 3362157..3362990 + 834 Protein_2950 DUF4942 domain-containing protein -
WN53_RS14910 3363759..3364145 - 387 WP_024484799.1 hypothetical protein -
WN53_RS27900 3364163..3364339 - 177 Protein_2952 Arc family DNA-binding protein -
WN53_RS14915 3364352..3364537 + 186 Protein_2953 arsenate reductase -
WN53_RS14920 3364617..3366089 - 1473 WP_024484800.1 SulP family inorganic anion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3336280..3369195 32915


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-105)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12020.66 Da        Isoelectric Point: 6.3209

>T53725 WP_024484798.1 NZ_CP011254:3361723-3362043 [Serratia fonticola]
MHISFVPATVPVASRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDTAIQQHIEAGITLADAVNFLVERYELVRTDRKGF
TSQEQTPFLTATDILRARRATGLMNT

Download         Length: 321 bp

>T53725 NZ_CP011254:3361723-3362043 [Serratia fonticola]
ATGCACATTTCATTTGTACCGGCCACGGTGCCGGTTGCGTCGCGCTTGTCACCCGTGCAAGTCTGGCAGCAACTGTTAAC
GTATCTGCTAGAGCACCATTACGGCCTGACACTCAACGACACGCCATTCCACGACGATACGGCCATTCAACAGCATATCG
AAGCGGGGATCACCCTAGCCGATGCAGTGAATTTTCTGGTGGAACGCTATGAACTGGTTCGCACTGACCGCAAAGGGTTT
ACATCGCAGGAGCAGACACCATTTCTGACCGCCACCGATATTCTCAGAGCAAGGCGTGCTACCGGGCTGATGAATACGTA
A

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11981.71 Da        Isoelectric Point: 7.0473

>AT53725 WP_024484797.1 NZ_CP011254:3361363-3361686 [Serratia fonticola]
MPLTLPHEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGSFNPKQLQKLDQAFPLFIDLLQAMLHSGELNPHHQHQVT
IQLAGLTCIADTRGSCGYVYISIYPTQ

Download         Length: 324 bp

>AT53725 NZ_CP011254:3361363-3361686 [Serratia fonticola]
ATGCCATTAACACTACCTCATGAATGGGGGTTACAAAGCGATATCACCCCGCGATTTGGCGCAAGATTGGTTCAGGAAGG
TAACCGGCTGCATTACCTGGCTGACAGGGCTGGGTTGACGGGGAGCTTTAACCCTAAGCAATTACAGAAACTGGATCAGG
CTTTCCCGTTGTTTATAGATCTGCTGCAAGCAATGCTGCATTCCGGTGAGCTAAATCCACACCATCAACATCAGGTGACC
ATTCAGCTTGCGGGTTTAACCTGCATAGCTGATACCCGTGGTAGCTGCGGCTACGTTTACATTTCTATTTATCCAACCCA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7HCV0

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7HBS3

References