Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2510427..2510954 Replicon chromosome
Accession NZ_CP011254
Organism Serratia fonticola strain DSM 4576

Toxin (Protein)


Gene name relE Uniprot ID A0A4U9U5W2
Locus tag WN53_RS27225 Protein ID WP_071784959.1
Coordinates 2510679..2510954 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0F7HAE1
Locus tag WN53_RS11195 Protein ID WP_024484723.1
Coordinates 2510427..2510675 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WN53_RS11175 2505607..2506815 - 1209 WP_024484721.1 PatB family C-S lyase -
WN53_RS11180 2506948..2508408 - 1461 WP_046808058.1 Na+/H+ antiporter NhaC -
WN53_RS11185 2508610..2509548 - 939 WP_024484722.1 transcriptional regulator MelR -
WN53_RS11195 2510427..2510675 + 249 WP_024484723.1 ribbon-helix-helix domain-containing protein Antitoxin
WN53_RS27225 2510679..2510954 + 276 WP_071784959.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WN53_RS11200 2510998..2511510 + 513 WP_024484724.1 AAA family ATPase -
WN53_RS11205 2512522..2513520 + 999 WP_024484725.1 membrane protein -
WN53_RS11210 2513598..2514869 - 1272 WP_024484726.1 HipA domain-containing protein -
WN53_RS11215 2514872..2515375 - 504 WP_024484727.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2505607..2515375 9768


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11083.44 Da        Isoelectric Point: 5.5280

>T53723 WP_071784959.1 NZ_CP011254:2510679-2510954 [Serratia fonticola]
MEIQWTQKAQDDLERIYRFACQFSRQHADNVLERLIIGTSGLADHPRIGVPQIRYEPREVRKILFDDYDVHYEIQHDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T53723 NZ_CP011254:2510679-2510954 [Serratia fonticola]
ATGGAAATACAGTGGACCCAAAAGGCTCAGGATGACTTGGAGCGTATTTATAGGTTTGCCTGTCAGTTCAGTCGGCAACA
TGCTGACAATGTGTTAGAGCGTTTGATCATCGGAACCTCAGGGCTCGCCGACCATCCAAGAATCGGTGTACCTCAGATAA
GATATGAACCACGAGAAGTGAGAAAAATCTTGTTTGATGATTATGACGTTCACTATGAAATTCAGCACGATACTATTTAT
ATTGTCGATCTTTGGCACACCCGAGAAGATCGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9006.36 Da        Isoelectric Point: 7.2045

>AT53723 WP_024484723.1 NZ_CP011254:2510427-2510675 [Serratia fonticola]
MGQPAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Download         Length: 249 bp

>AT53723 NZ_CP011254:2510427-2510675 [Serratia fonticola]
ATGGGACAACCCGCGAAACAGACGATCAGCGCTCAGATCCCCGCAGAGCTTGCTGCGGCGGTTGAAAACCTGGCTATTGA
ACTGGACAGATCCAAAAGCTGGGTGATTAAGGAAGCATTGACTGCCATGATTGAAGAGAGAGAGCGGCGGCATCAGCAGA
TTTTGAAAGGCCTTGCTGATGTCGATGCGGGAAGGGTGGTTAGCCATGCGGATGTGGTTGACTTCGCTAACAAACTGAAA
AAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U9U5W2

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7HAE1

References