Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2487294..2487856 Replicon chromosome
Accession NZ_CP011254
Organism Serratia fonticola strain DSM 4576

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0F7HBD7
Locus tag WN53_RS11070 Protein ID WP_024486364.1
Coordinates 2487294..2487611 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0F7D1U7
Locus tag WN53_RS11075 Protein ID WP_024486363.1
Coordinates 2487611..2487856 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WN53_RS11055 2482990..2484084 + 1095 WP_024486367.1 LPS export ABC transporter permease LptF -
WN53_RS11060 2484084..2485154 + 1071 WP_024486366.1 LPS export ABC transporter permease LptG -
WN53_RS11065 2485256..2487052 - 1797 WP_051346379.1 hypothetical protein -
WN53_RS11070 2487294..2487611 - 318 WP_024486364.1 CcdB family protein Toxin
WN53_RS11075 2487611..2487856 - 246 WP_024486363.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
WN53_RS11080 2487946..2488275 - 330 WP_021179117.1 multidrug efflux SMR transporter -
WN53_RS11085 2488287..2488646 - 360 WP_024486362.1 multidrug efflux SMR transporter -
WN53_RS11090 2488908..2489576 - 669 WP_046808057.1 hypothetical protein -
WN53_RS11095 2489587..2490222 - 636 WP_024484709.1 phosphate propanoyltransferase -
WN53_RS11100 2490258..2490692 - 435 WP_024484710.1 BMC domain-containing protein -
WN53_RS11105 2490703..2491653 - 951 WP_024484711.1 choline TMA-lyase-activating enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-104)

Antitoxin

Post-segregation antitoxin CcdA

(9-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11652.62 Da        Isoelectric Point: 8.0501

>T53722 WP_024486364.1 NZ_CP011254:c2487611-2487294 [Serratia fonticola]
MKQFSVYKNQSKNKKAYPFFIVVQSDLLDHLSTRLVMPLALKHATNSQVKALTPVLSVDQQDYVILTSLLTTTDVKNLNA
DCLVTNAAHLRDELVAAIDLLVLGI

Download         Length: 318 bp

>T53722 NZ_CP011254:c2487611-2487294 [Serratia fonticola]
ATGAAACAATTTTCTGTTTATAAAAATCAATCTAAAAACAAAAAAGCCTATCCTTTCTTTATCGTTGTTCAGTCCGATTT
ACTCGATCACCTTAGCACTCGTTTGGTCATGCCCTTGGCTTTAAAGCATGCAACAAACTCACAGGTCAAAGCACTGACTC
CTGTTTTGTCTGTGGATCAACAAGATTACGTGATCCTTACTAGTTTACTGACGACTACGGATGTCAAAAATCTTAATGCA
GATTGCCTAGTTACCAATGCAGCCCATCTGCGTGATGAGCTGGTTGCGGCCATCGACCTGTTAGTTTTGGGCATTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8941.18 Da        Isoelectric Point: 5.0644

>AT53722 WP_024486363.1 NZ_CP011254:c2487856-2487611 [Serratia fonticola]
MGAVSVIKKRNTNVYLRVDLIEQAKALDLNLSATLNHALELAVKKGQRERWLAENRAGLEALNGFVEENGLFSDDADFGV
L

Download         Length: 246 bp

>AT53722 NZ_CP011254:c2487856-2487611 [Serratia fonticola]
ATGGGAGCCGTTTCAGTAATAAAAAAACGCAATACTAACGTATACTTGCGTGTCGACCTGATTGAACAGGCTAAAGCATT
AGACCTAAACTTATCGGCTACACTAAACCACGCATTAGAACTCGCAGTGAAGAAGGGGCAACGTGAACGTTGGTTAGCGG
AAAATCGTGCTGGTCTTGAAGCATTGAATGGCTTCGTTGAGGAGAACGGTCTTTTTTCTGATGATGCTGACTTTGGTGTC
CTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7HBD7

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7D1U7

References