Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2418915..2419486 Replicon chromosome
Accession NZ_CP011254
Organism Serratia fonticola strain DSM 4576

Toxin (Protein)


Gene name relE Uniprot ID A0A0F7HBA7
Locus tag WN53_RS10790 Protein ID WP_021807486.1
Coordinates 2419211..2419486 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0F7HA06
Locus tag WN53_RS10785 Protein ID WP_024483400.1
Coordinates 2418915..2419202 (+) Length 96 a.a.

Genomic Context

WN53_RS10785WN53_RS10790WN53_RS10810WN53_RS10755WN53_RS10760WN53_RS10765WN53_RS10770WN53_RS10775WN53_RS10780WN53_RS10795WN53_RS10800WN53_RS10805
Location: 2418915..2419202 (288 bp)
Type: Antitoxin
Protein ID: WP_024483400.1
Location: 2419211..2419486 (276 bp)
Type: Toxin
Protein ID: WP_021807486.1
Location: 2423849..2424373 (525 bp)
Type: Others
Protein ID: WP_024483404.1
Location: 2414151..2414939 (789 bp)
Type: Others
Protein ID: WP_024483394.1
Location: 2414939..2415790 (852 bp)
Type: Others
Protein ID: WP_024483395.1
Location: 2415783..2416868 (1086 bp)
Type: Others
Protein ID: WP_024483396.1
Location: 2416868..2417449 (582 bp)
Type: Others
Protein ID: WP_024483397.1
Location: 2417453..2417896 (444 bp)
Type: Others
Protein ID: WP_024483398.1
Location: 2417897..2418625 (729 bp)
Type: Others
Protein ID: WP_024483399.1
Location: 2419483..2419947 (465 bp)
Type: Others
Protein ID: WP_024483401.1
Location: 2420407..2422545 (2139 bp)
Type: Others
Protein ID: WP_024483402.1
Location: 2422857..2423744 (888 bp)
Type: Others
Protein ID: WP_024483403.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
WN53_RS107552414151..2414939-789WP_024483394.1phosphonate C-P lyase system protein PhnK-
WN53_RS107602414939..2415790-852WP_024483395.1alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ-
WN53_RS107652415783..2416868-1086WP_024483396.1carbon-phosphorus lyase complex subunit PhnI-
WN53_RS107702416868..2417449-582WP_024483397.1phosphonate C-P lyase system protein PhnH-
WN53_RS107752417453..2417896-444WP_024483398.1phosphonate C-P lyase system protein PhnG-
WN53_RS107802417897..2418625-729WP_024483399.1phosphonate metabolism transcriptional regulator PhnF-
WN53_RS107852418915..2419202+288WP_024483400.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
WN53_RS107902419211..2419486+276WP_021807486.1type II toxin-antitoxin system RelE/ParE family toxinToxin
WN53_RS107952419483..2419947-465WP_024483401.1anaerobic ribonucleoside-triphosphate reductase-activating protein-
WN53_RS108002420407..2422545-2139WP_024483402.1anaerobic ribonucleoside-triphosphate reductase-
WN53_RS108052422857..2423744-888WP_024483403.1LysR family transcriptional regulator-
WN53_RS108102423849..2424373+525WP_024483404.1NAD(P)H-dependent oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-44)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10623.27 Da        Isoelectric Point: 4.2503

>T53721 WP_021807486.1 NZ_CP011254:2419211-2419486 [Serratia fonticola]
MRIEWDDVALQDRERIFEFLYPLNPLAAEQVDDEIELAVESLLENPEMGRPWYGEARKLVISKASLLLIYVILDEVIKVL
AVAHQREKFPN

Download         Length: 276 bp

>T53721 NZ_CP011254:2419211-2419486 [Serratia fonticola]
ATGCGCATCGAATGGGACGACGTTGCGTTGCAAGATCGGGAACGCATTTTTGAATTTCTTTATCCACTCAATCCATTGGC
TGCGGAACAAGTTGATGATGAGATTGAACTTGCCGTTGAGTCGCTGCTAGAAAACCCAGAAATGGGCAGGCCTTGGTATG
GGGAAGCTCGCAAACTGGTGATCAGTAAAGCCTCCCTATTGCTGATTTATGTCATTTTGGATGAGGTAATAAAGGTTTTA
GCCGTCGCCCATCAGCGTGAAAAATTCCCCAATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10987.38 Da        Isoelectric Point: 8.0314

>AT53721 WP_024483400.1 NZ_CP011254:2418915-2419202 [Serratia fonticola]
MESRIQFRIENETKLLAQKAAEAKGTTLSEACRRLAQQMADDQRAAEEHENWLKDKVDAAFARLHEGEAVYLTQRQAEER
MSDFKTKVRAKYATK

Download         Length: 288 bp

>AT53721 NZ_CP011254:2418915-2419202 [Serratia fonticola]
ATGGAAAGCCGTATCCAGTTTCGCATTGAAAATGAAACTAAACTGTTGGCACAGAAAGCTGCTGAAGCGAAAGGGACGAC
CTTAAGTGAAGCCTGTCGGCGTTTAGCGCAACAAATGGCGGACGATCAGCGTGCTGCTGAAGAACACGAAAACTGGTTGA
AAGATAAGGTTGATGCAGCCTTTGCCCGTTTACATGAAGGAGAGGCTGTTTATCTTACCCAGCGGCAAGCTGAGGAGAGA
ATGAGCGACTTTAAAACCAAAGTCAGGGCGAAATACGCAACCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F7HBA7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F7HA06

References