Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2418915..2419486 Replicon chromosome
Accession NZ_CP011254
Organism Serratia fonticola strain DSM 4576

Toxin (Protein)


Gene name relE Uniprot ID A0A0F7HBA7
Locus tag WN53_RS10790 Protein ID WP_021807486.1
Coordinates 2419211..2419486 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0F7HA06
Locus tag WN53_RS10785 Protein ID WP_024483400.1
Coordinates 2418915..2419202 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WN53_RS10755 2414151..2414939 - 789 WP_024483394.1 phosphonate C-P lyase system protein PhnK -
WN53_RS10760 2414939..2415790 - 852 WP_024483395.1 alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ -
WN53_RS10765 2415783..2416868 - 1086 WP_024483396.1 carbon-phosphorus lyase complex subunit PhnI -
WN53_RS10770 2416868..2417449 - 582 WP_024483397.1 phosphonate C-P lyase system protein PhnH -
WN53_RS10775 2417453..2417896 - 444 WP_024483398.1 phosphonate C-P lyase system protein PhnG -
WN53_RS10780 2417897..2418625 - 729 WP_024483399.1 phosphonate metabolism transcriptional regulator PhnF -
WN53_RS10785 2418915..2419202 + 288 WP_024483400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
WN53_RS10790 2419211..2419486 + 276 WP_021807486.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WN53_RS10795 2419483..2419947 - 465 WP_024483401.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
WN53_RS10800 2420407..2422545 - 2139 WP_024483402.1 anaerobic ribonucleoside-triphosphate reductase -
WN53_RS10805 2422857..2423744 - 888 WP_024483403.1 LysR family transcriptional regulator -
WN53_RS10810 2423849..2424373 + 525 WP_024483404.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-44)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10623.27 Da        Isoelectric Point: 4.2503

>T53721 WP_021807486.1 NZ_CP011254:2419211-2419486 [Serratia fonticola]
MRIEWDDVALQDRERIFEFLYPLNPLAAEQVDDEIELAVESLLENPEMGRPWYGEARKLVISKASLLLIYVILDEVIKVL
AVAHQREKFPN

Download         Length: 276 bp

>T53721 NZ_CP011254:2419211-2419486 [Serratia fonticola]
ATGCGCATCGAATGGGACGACGTTGCGTTGCAAGATCGGGAACGCATTTTTGAATTTCTTTATCCACTCAATCCATTGGC
TGCGGAACAAGTTGATGATGAGATTGAACTTGCCGTTGAGTCGCTGCTAGAAAACCCAGAAATGGGCAGGCCTTGGTATG
GGGAAGCTCGCAAACTGGTGATCAGTAAAGCCTCCCTATTGCTGATTTATGTCATTTTGGATGAGGTAATAAAGGTTTTA
GCCGTCGCCCATCAGCGTGAAAAATTCCCCAATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10987.38 Da        Isoelectric Point: 8.0314

>AT53721 WP_024483400.1 NZ_CP011254:2418915-2419202 [Serratia fonticola]
MESRIQFRIENETKLLAQKAAEAKGTTLSEACRRLAQQMADDQRAAEEHENWLKDKVDAAFARLHEGEAVYLTQRQAEER
MSDFKTKVRAKYATK

Download         Length: 288 bp

>AT53721 NZ_CP011254:2418915-2419202 [Serratia fonticola]
ATGGAAAGCCGTATCCAGTTTCGCATTGAAAATGAAACTAAACTGTTGGCACAGAAAGCTGCTGAAGCGAAAGGGACGAC
CTTAAGTGAAGCCTGTCGGCGTTTAGCGCAACAAATGGCGGACGATCAGCGTGCTGCTGAAGAACACGAAAACTGGTTGA
AAGATAAGGTTGATGCAGCCTTTGCCCGTTTACATGAAGGAGAGGCTGTTTATCTTACCCAGCGGCAAGCTGAGGAGAGA
ATGAGCGACTTTAAAACCAAAGTCAGGGCGAAATACGCAACCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7HBA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7HA06

References