Detailed information of TA system TA053720

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 1912251..1913035
• Replicon: chromosome
• Accession: NZ_CP011254
• Organism: Serratia fonticola strain DSM 4576

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A0F7H968
• Locus tag: WN53_RS08445
• Protein ID: WP_024483225.1
• Coordinates: 1912251..1912586 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: WN53_RS08450
• Protein ID: WP_080660650.1
• Coordinates: 1912661..1913035 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WN53_RS08410	1907975..1908796	+	822	WP_024483232.1	DUF945 domain-containing protein	-
WN53_RS08415	1909042..1909710	+	669	WP_024483231.1	EcsC family protein	-
WN53_RS08420	1909827..1910129	+	303	WP_024483230.1	hypothetical protein	-
WN53_RS08425	1910126..1910452	+	327	WP_024483229.1	hypothetical protein	-
WN53_RS08430	1910527..1910979	+	453	WP_024483228.1	hypothetical protein	-
WN53_RS08435	1911252..1911728	+	477	WP_046808043.1	DNA repair protein RadC	-
WN53_RS08440	1911751..1912239	+	489	WP_024483226.1	hypothetical protein	-
WN53_RS08445	1912251..1912586	+	336	WP_024483225.1	TA system toxin CbtA family protein	Toxin
WN53_RS08450	1912661..1913035	+	375	WP_080660650.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
WN53_RS27860	1913125..1913580	+	456	WP_051346226.1	hypothetical protein	-
WN53_RS27150	1913529..1913969	-	441	WP_071784933.1	HNH endonuclease	-
WN53_RS08460	1914152..1914442	+	291	WP_024483223.1	hypothetical protein	-
WN53_RS08465	1914487..1914762	-	276	WP_024483222.1	hypothetical protein	-
WN53_RS08470	1914985..1915664	-	680	Protein_1680	IS1595 family transposase	-
WN53_RS08475	1915884..1917203	-	1320	WP_024483221.1	McrC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1889502..1948601	59099

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-107)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12515.34 Da
• Isoelectric Point: 6.2119

>T53720 WP_024483225.1 NZ_CP011254:1912251-1912586 [Serratia fonticola]
MKTTNEVTHTALNVSPALIEYQQLLAWLLDHCYGLTLNDTPYHDQLAIARQIEYGMTVRETVNELVQKFDLVRVDRPGFS
MLAQDPTLSGSDMLRARSALGLRTPVNSRLV

Nucleotide

• Length: 336 bp

>T53720 NZ_CP011254:1912251-1912586 [Serratia fonticola]
ATGAAGACCACCAACGAAGTAACTCATACCGCATTGAACGTCAGCCCTGCCTTGATTGAATACCAGCAACTGCTCGCCTG
GTTACTGGACCACTGTTACGGACTCACGCTCAACGATACGCCATATCACGATCAATTGGCTATCGCCCGACAGATTGAAT
ACGGGATGACCGTACGTGAAACCGTCAACGAGCTGGTCCAAAAATTCGACTTGGTACGCGTTGACCGCCCCGGCTTCAGC
ATGTTGGCTCAGGATCCTACTCTGAGTGGAAGCGACATGTTGCGAGCTCGAAGCGCACTGGGGTTACGAACTCCTGTTAA
TTCCCGCCTCGTTTAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13817.94 Da
• Isoelectric Point: 6.2172

>AT53720 WP_080660650.1 NZ_CP011254:1912661-1913035 [Serratia fonticola]
MVKISDPKTSSSIPDPIPYWGLQYDITPRLGARLIQQGARLHFLGDRAGCIGIFDPEVPQALELAFPVLVERLERLLRLG
ELDPRRQHCVAVQHAGFIYEADTLGSFGYVYIAVYQAARPPVAE

Nucleotide

• Length: 375 bp

>AT53720 NZ_CP011254:1912661-1913035 [Serratia fonticola]
ATGGTGAAAATCTCCGATCCCAAGACCTCGAGCAGTATTCCTGACCCGATACCATACTGGGGCCTGCAGTATGACATCAC
GCCGCGCTTAGGAGCCCGCCTAATACAACAAGGTGCTCGTTTACATTTTCTAGGAGACCGCGCTGGCTGTATCGGCATCT
TTGACCCTGAAGTCCCACAGGCTCTTGAACTGGCGTTTCCGGTGTTAGTTGAACGGCTGGAGAGATTATTACGGTTAGGT
GAACTCGACCCACGGCGACAACATTGTGTCGCTGTTCAGCATGCTGGTTTTATCTATGAAGCCGATACGCTGGGCAGTTT
TGGTTATGTGTATATCGCAGTCTATCAAGCAGCGCGGCCACCCGTTGCAGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0F7H968