Detailed information of TA system TA053718

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1796176..1797755
• Replicon: chromosome
• Accession: NZ_CP011254
• Organism: Serratia fonticola strain DSM 4576

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A0F7HAG6
• Locus tag: WN53_RS07970
• Protein ID: WP_024483317.1
• Coordinates: 1796176..1797495 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: WN53_RS07975
• Protein ID: WP_024483316.1
• Coordinates: 1797495..1797755 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WN53_RS27855	1792404..1792725	-	322	Protein_1569	DUF4158 domain-containing protein	-
WN53_RS07945	1792982..1793272	-	291	Protein_1570	VapC toxin family PIN domain ribonuclease	-
WN53_RS07950	1793285..1794337	-	1053	WP_046808042.1	hypothetical protein	-
WN53_RS07955	1794430..1794996	-	567	WP_024483320.1	NAD(P)H-dependent oxidoreductase	-
WN53_RS07960	1795185..1795904	-	720	WP_024483319.1	4'-phosphopantetheinyl transferase superfamily protein	-
WN53_RS07965	1795987..1796166	+	180	WP_024483318.1	hypothetical protein	-
WN53_RS07970	1796176..1797495	-	1320	WP_024483317.1	type II toxin-antitoxin system HipA family toxin	Toxin
WN53_RS07975	1797495..1797755	-	261	WP_024483316.1	helix-turn-helix domain-containing protein	Antitoxin
WN53_RS07980	1798067..1799431	-	1365	WP_024483315.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
WN53_RS07985	1799545..1801185	-	1641	WP_024483314.1	membrane protein insertase YidC	-
WN53_RS27125	1801188..1801445	-	258	WP_025120915.1	membrane protein insertion efficiency factor YidD	-
WN53_RS07990	1801409..1801768	-	360	WP_004950547.1	ribonuclease P protein component	-
WN53_RS27130	1801787..1801927	-	141	WP_004093983.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1792543..1792725	182

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 48808.06 Da
• Isoelectric Point: 7.0957

>T53718 WP_024483317.1 NZ_CP011254:c1797495-1796176 [Serratia fonticola]
MADLNAYMNGYKVGIFSREGTGAHMFQYVDTWLNQPGSRPISLSMPLRRRPYKGAEVYNFFDNLLPDNPEIRDRILARYS
ADSTQPFDLLARIGADTIGALQLLPQNADPGDIRTINYKALSNQELASILTGYKAGAPLGMIEDVEDFRISLAGAQEKTA
LLYLENRWCLPIAATPTTHIIKLPIGKIESHSYSIDLSDSVENEYLCALLAKEFGLSVPHCFIMQVGDIKALAVERFDRR
YASDGSWIMRLPQEDFCQVLNVPSARKYENQGGPGISEIMEYLLGSVTAEKDRYNFMKAQVLFWLLAATDGHAKNFSVFI
EADGRFRLTPLYDILSVYPVFGGRGLHPKDAKLAMGLKGSKGKKYAIEQIFPRHFFQTAKTVGFERAAMEGILTEMAGSV
DTVIERVTQQLPAGFPPAISNAILKGLKARSARLTVGWD

Nucleotide

• Length: 1320 bp

>T53718 NZ_CP011254:c1797495-1796176 [Serratia fonticola]
ATGGCTGACCTAAATGCCTACATGAATGGTTATAAGGTAGGGATTTTCAGCCGTGAGGGCACTGGCGCCCATATGTTCCA
ATACGTGGACACTTGGCTTAACCAACCTGGAAGCCGTCCTATATCGCTCTCCATGCCCTTGAGGCGACGGCCTTACAAAG
GGGCAGAAGTCTACAACTTCTTCGATAACCTGCTGCCGGACAACCCTGAGATCCGGGACAGGATCCTAGCGCGCTACAGT
GCTGACTCGACTCAACCCTTCGACCTTTTGGCACGTATCGGTGCTGACACCATTGGTGCCCTGCAACTCTTGCCACAAAA
TGCAGACCCGGGGGACATTCGCACCATAAACTATAAAGCGCTATCCAACCAAGAACTGGCAAGCATACTTACAGGCTACA
AAGCTGGTGCCCCTCTGGGCATGATTGAGGATGTTGAAGATTTCCGAATTTCCCTGGCCGGGGCCCAAGAAAAGACGGCT
CTCCTCTATCTCGAAAACCGTTGGTGTTTACCGATCGCAGCCACACCAACCACCCATATCATTAAGCTACCCATCGGAAA
AATAGAAAGCCACTCATACAGTATCGACTTGTCAGACAGTGTCGAAAACGAGTATCTCTGCGCTCTACTGGCCAAGGAAT
TTGGATTATCAGTCCCCCATTGCTTCATTATGCAAGTGGGTGACATAAAAGCCTTAGCAGTGGAACGCTTTGACCGCCGG
TATGCCTCAGACGGCAGTTGGATCATGCGACTGCCCCAAGAAGATTTCTGCCAGGTTTTAAATGTTCCCTCGGCACGTAA
ATACGAAAATCAGGGGGGACCAGGGATAAGCGAGATCATGGAATATCTGCTTGGCTCGGTGACAGCGGAAAAGGATCGCT
ATAATTTCATGAAGGCACAGGTATTGTTCTGGTTGCTAGCCGCAACCGATGGACATGCAAAGAACTTCTCGGTGTTCATT
GAAGCTGATGGGCGTTTTCGTTTAACCCCCTTGTACGACATTCTATCTGTCTACCCGGTGTTTGGTGGCAGAGGCCTTCA
TCCGAAAGATGCCAAGCTCGCTATGGGCCTAAAAGGAAGCAAGGGAAAGAAGTACGCCATTGAGCAAATATTCCCACGCC
ACTTCTTCCAAACAGCCAAAACAGTAGGATTTGAGCGCGCCGCCATGGAGGGGATCCTGACGGAAATGGCTGGATCCGTT
GATACCGTTATCGAGCGGGTAACACAGCAGTTGCCAGCAGGCTTTCCTCCCGCCATCAGTAACGCTATTTTAAAGGGCCT
AAAAGCCCGTTCCGCAAGGCTGACAGTGGGCTGGGATTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9831.20 Da
• Isoelectric Point: 7.9783

>AT53718 WP_024483316.1 NZ_CP011254:c1797755-1797495 [Serratia fonticola]
MKITNAKQLSIYLRDVRLAENLSQEKVASRVGIRQDTVSNFELQPGTTKLETFFKILSALNLELEVKPRGSQSCETKSTD
GWKEEW

Nucleotide

• Length: 261 bp

>AT53718 NZ_CP011254:c1797755-1797495 [Serratia fonticola]
ATGAAGATCACCAATGCCAAGCAGCTCAGCATCTACTTGCGAGATGTCCGCCTCGCAGAAAATCTTTCACAAGAAAAAGT
AGCCAGTAGGGTTGGGATCCGTCAAGACACCGTGTCCAACTTTGAACTCCAGCCGGGAACGACCAAATTAGAGACTTTCT
TCAAAATCCTGTCTGCGCTGAATCTGGAGCTGGAAGTAAAACCCAGAGGTAGCCAGAGCTGCGAAACCAAAAGTACCGAT
GGTTGGAAAGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A0F7HAG6