Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 548022..548691 Replicon chromosome
Accession NZ_CP011254
Organism Serratia fonticola strain DSM 4576

Toxin (Protein)


Gene name cptA Uniprot ID A0A3G2FJN3
Locus tag WN53_RS02325 Protein ID WP_024486356.1
Coordinates 548022..548444 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3G2FIP7
Locus tag WN53_RS02330 Protein ID WP_024486357.1
Coordinates 548425..548691 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WN53_RS02305 543817..544335 + 519 WP_021179810.1 flavodoxin FldB -
WN53_RS02310 544420..545808 - 1389 WP_024486353.1 cell envelope integrity protein CreD -
WN53_RS02315 545912..547330 - 1419 WP_024486354.1 two-component system sensor histidine kinase CreC -
WN53_RS02320 547327..548022 - 696 WP_024486355.1 two-component system response regulator CreB -
WN53_RS02325 548022..548444 - 423 WP_024486356.1 protein YgfX Toxin
WN53_RS02330 548425..548691 - 267 WP_024486357.1 FAD assembly factor SdhE Antitoxin
WN53_RS02335 548992..549984 + 993 WP_024486358.1 tRNA-modifying protein YgfZ -
WN53_RS02340 550024..550521 - 498 WP_024486359.1 DUF2165 domain-containing protein -
WN53_RS02345 550754..551428 - 675 WP_024486360.1 hemolysin III family protein -
WN53_RS02350 551665..552273 + 609 WP_024486361.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 542066..608645 66579
- flank IS/Tn - - 552736..553878 1142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16425.30 Da        Isoelectric Point: 9.9516

>T53717 WP_024486356.1 NZ_CP011254:c548444-548022 [Serratia fonticola]
VAQWRCDVRVSWRTQLISLLTHGLLILLILIAPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLAERRIEWHGQ
EWLMVNKPWMPGFGILLSLQQIDGKKRHRLWLASDSMSKADWRQLRQGLLFEQSATDEDV

Download         Length: 423 bp

>T53717 NZ_CP011254:c548444-548022 [Serratia fonticola]
GTGGCCCAGTGGCGATGTGATGTCCGCGTTTCCTGGCGTACCCAGTTAATCTCGTTGTTGACTCACGGCCTGCTGATTTT
GCTGATCCTGATCGCCCCGTGGCCGGAAGGCTATGGCCCGATTTGGTTGGTGCTGTTGACGTTGGTGGTGTTTGAGTGCA
TTCGCAGCCAAAAGCGCATTGCATCCAGGCAGGGAGAACTGCGGTTGCTGGCTGAACGCCGGATTGAGTGGCATGGCCAG
GAATGGCTGATGGTGAACAAGCCCTGGATGCCTGGGTTCGGTATTTTACTGTCGCTTCAGCAGATCGACGGCAAGAAACG
CCATCGGCTGTGGTTGGCTTCGGATTCCATGAGCAAAGCGGATTGGCGCCAACTGCGTCAGGGGTTGTTGTTTGAACAAT
CCGCTACCGACGAGGACGTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10342.85 Da        Isoelectric Point: 6.0634

>AT53717 WP_024486357.1 NZ_CP011254:c548691-548425 [Serratia fonticola]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDADKAVFIRLLECDDPDLFNWLMNHGAPHDQDLQRMVSLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT53717 NZ_CP011254:c548691-548425 [Serratia fonticola]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGCGGCATGCGCGAGTTGGATATCTCGATCATGCCGTT
TTTCGAACATGAATACGATACGCTGAGTGATGCAGACAAGGCCGTATTCATCCGCTTGCTCGAATGTGACGACCCCGATT
TGTTTAACTGGCTGATGAATCATGGCGCTCCGCACGATCAAGATCTGCAGAGAATGGTGTCCCTGATCCAAACGCGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2FJN3

Antitoxin

Source ID Structure
AlphaFold DB A0A3G2FIP7

References