Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4066652..4067302 Replicon chromosome
Accession NZ_CP011253
Organism Pandoraea oxalativorans strain DSM 23570

Toxin (Protein)


Gene name hicA Uniprot ID A0A0E3YEZ9
Locus tag MB84_RS17860 Protein ID WP_046292735.1
Coordinates 4067117..4067302 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0E3YDL8
Locus tag MB84_RS17855 Protein ID WP_046292734.1
Coordinates 4066652..4067071 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MB84_RS17835 4062588..4063382 - 795 WP_046292730.1 substrate-binding domain-containing protein -
MB84_RS17840 4063479..4064792 - 1314 WP_046292731.1 MFS transporter -
MB84_RS17845 4065107..4066078 + 972 WP_046292732.1 LysR family transcriptional regulator -
MB84_RS17850 4066198..4066626 + 429 WP_046292733.1 hypothetical protein -
MB84_RS17855 4066652..4067071 - 420 WP_046292734.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MB84_RS17860 4067117..4067302 - 186 WP_046292735.1 type II toxin-antitoxin system HicA family toxin Toxin
MB84_RS17865 4067549..4068736 - 1188 WP_046292736.1 alpha-hydroxy-acid oxidizing protein -
MB84_RS17870 4068802..4069275 - 474 WP_039396747.1 Lrp/AsnC family transcriptional regulator -
MB84_RS17875 4069545..4070639 + 1095 WP_046292737.1 porin -
MB84_RS17880 4070860..4072215 + 1356 WP_157122915.1 amino acid permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7029.08 Da        Isoelectric Point: 11.5775

>T53715 WP_046292735.1 NZ_CP011253:c4067302-4067117 [Pandoraea oxalativorans]
MKYSEFRRWLRRQGAAFEQHRAGSSHFRVTLNGRSTVFPDHGAKEMGQGLVEVIKKQLGLK

Download         Length: 186 bp

>T53715 NZ_CP011253:c4067302-4067117 [Pandoraea oxalativorans]
ATGAAGTACAGCGAGTTCAGAAGGTGGCTCCGTCGGCAGGGGGCCGCTTTTGAGCAGCATCGAGCCGGTTCCAGCCATTT
TCGTGTGACGCTCAATGGACGTTCCACGGTCTTTCCCGATCATGGTGCGAAGGAAATGGGGCAGGGTCTCGTGGAAGTTA
TCAAGAAGCAGTTGGGGCTGAAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15601.14 Da        Isoelectric Point: 7.0192

>AT53715 WP_046292734.1 NZ_CP011253:c4067071-4066652 [Pandoraea oxalativorans]
MLTYPITLKRDTNGTLLVTFPDVPEAITVGENEEDAREQALEALEAALEFYFAQKTPIPWPTRPKRGQETITLPIMASIK
VLLANEMIAQNVRKAELARRMHVNQVQVDRLLKLGYASRLDAVESAFAVLGKRLEVRAV

Download         Length: 420 bp

>AT53715 NZ_CP011253:c4067071-4066652 [Pandoraea oxalativorans]
ATGTTGACCTATCCCATCACGCTTAAGCGAGATACCAACGGCACGTTGTTGGTGACGTTCCCTGACGTGCCTGAAGCGAT
TACGGTCGGTGAGAACGAAGAGGACGCGCGTGAACAGGCGCTCGAAGCGCTTGAGGCAGCGTTGGAGTTCTACTTCGCGC
AGAAGACACCGATTCCATGGCCGACGCGTCCGAAGCGGGGGCAGGAAACGATTACGCTGCCGATCATGGCGTCGATCAAA
GTCCTGCTTGCCAACGAGATGATCGCCCAGAATGTGCGCAAGGCCGAGCTAGCGAGACGCATGCACGTGAATCAGGTGCA
AGTGGATCGCCTTTTGAAGCTCGGATATGCATCGCGACTCGATGCCGTGGAGTCCGCGTTCGCGGTACTAGGAAAGCGCC
TTGAGGTTCGGGCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3YEZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3YDL8

References