Detailed information of TA system TA053714

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3718174..3718760
• Replicon: chromosome
• Accession: NZ_CP011253
• Organism: Pandoraea oxalativorans strain DSM 23570

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MB84_RS29065
• Protein ID: WP_084010052.1
• Coordinates: 3718174..3718428 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0E3YDQ7
• Locus tag: MB84_RS16355
• Protein ID: WP_046292539.1
• Coordinates: 3718425..3718760 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MB84_RS16350	3715510..3716733	+	1224	WP_046292538.1	CoA transferase	-
MB84_RS29065	3718174..3718428	+	255	WP_084010052.1	type II toxin-antitoxin system HicA family toxin	Toxin
MB84_RS16355	3718425..3718760	+	336	WP_046292539.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MB84_RS16360	3718983..3719684	-	702	WP_052653466.1	hypothetical protein	-
MB84_RS16370	3720125..3721147	+	1023	WP_046293183.1	IS110 family transposase	-
MB84_RS16375	3721474..3722295	-	822	WP_044453167.1	IS21-like element helper ATPase IstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9449.85 Da
• Isoelectric Point: 10.2015

>T53714 WP_084010052.1 NZ_CP011253:3718174-3718428 [Pandoraea oxalativorans]
MKSKSRRTLDLLFSRPTPASVKWGDLVALFHDLGGELDEREGSRVAVYLFNQVKVLHRPHPSPDVDKGAVASIRKWLEEN
GVKP

Nucleotide

• Length: 255 bp

>T53714 NZ_CP011253:3718174-3718428 [Pandoraea oxalativorans]
ATGAAATCCAAATCAAGACGAACTCTTGATCTGCTTTTCTCTCGCCCAACTCCGGCCAGCGTGAAGTGGGGCGACCTCGT
GGCACTGTTTCATGATCTTGGCGGAGAGCTGGACGAGCGAGAGGGGTCCCGCGTCGCGGTCTATCTGTTCAACCAAGTCA
AGGTGCTTCATCGACCGCACCCATCCCCCGATGTGGACAAAGGTGCAGTTGCATCCATTCGCAAGTGGCTTGAAGAAAAC
GGAGTGAAACCATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12004.74 Da
• Isoelectric Point: 6.0757

>AT53714 WP_046292539.1 NZ_CP011253:3718425-3718760 [Pandoraea oxalativorans]
MNNIMIIGGHKAVIAYDPEIDMFRGEFVGLNGGADFYAADVPGLRAEGERSLKIFLEECARRGIEPQKQFSGKFVIRLAP
KAHEAAAIAAAAHGQSLNQWVAETLEHAVLA

Nucleotide

• Length: 336 bp

>AT53714 NZ_CP011253:3718425-3718760 [Pandoraea oxalativorans]
ATGAACAACATCATGATCATCGGTGGACACAAGGCAGTCATCGCCTACGATCCAGAGATCGACATGTTCAGAGGTGAGTT
TGTAGGTCTGAATGGGGGAGCAGATTTTTACGCTGCCGACGTTCCAGGATTGCGCGCCGAAGGCGAACGTTCGCTGAAAA
TCTTTCTAGAGGAATGCGCACGCCGTGGCATCGAGCCGCAGAAGCAGTTTTCCGGAAAATTCGTTATTCGCCTAGCGCCG
AAGGCTCACGAGGCTGCTGCAATCGCGGCAGCTGCACATGGGCAGAGCCTAAATCAATGGGTGGCGGAAACGCTTGAGCA
TGCGGTGCTCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E3YDQ7