Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1257785..1259630 Replicon chromosome
Accession NZ_CP011253
Organism Pandoraea oxalativorans strain DSM 23570

Toxin (Protein)


Gene name doc Uniprot ID A0A0E3YG52
Locus tag MB84_RS05775 Protein ID WP_052652991.1
Coordinates 1257785..1258693 (+) Length 303 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag MB84_RS05780 Protein ID WP_084010003.1
Coordinates 1258695..1259630 (+) Length 312 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MB84_RS05750 1253133..1254209 + 1077 WP_046293451.1 porin -
MB84_RS05755 1254618..1255390 + 773 Protein_1139 ABC transporter ATP-binding protein -
MB84_RS05760 1255465..1256247 + 783 WP_046291084.1 ABC transporter permease -
MB84_RS05765 1256302..1257075 + 774 WP_046291085.1 SDR family oxidoreductase -
MB84_RS05770 1257116..1257673 + 558 WP_039400236.1 cupin domain-containing protein -
MB84_RS05775 1257785..1258693 + 909 WP_052652991.1 alpha/beta fold hydrolase Toxin
MB84_RS05780 1258695..1259630 + 936 WP_084010003.1 IclR family transcriptional regulator Antitoxin
MB84_RS05785 1259627..1260442 + 816 WP_046291086.1 SDR family oxidoreductase -
MB84_RS05790 1260435..1262087 + 1653 WP_046291087.1 thiamine pyrophosphate-binding protein -
MB84_RS05795 1262080..1262898 + 819 WP_046291088.1 aspartate dehydrogenase -
MB84_RS05800 1262912..1264408 + 1497 WP_046291089.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-288)

Antitoxin

Transcription regulator IclR, N-terminal

(47-95)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 31412.40 Da        Isoelectric Point: 5.3339

>T53713 WP_052652991.1 NZ_CP011253:1257785-1258693 [Pandoraea oxalativorans]
MQAEAHQHEAPEDDVVASLRARLDAFAYSTVATRAGTVGYRCAGAERDAGVPVVMLHGIGSGAASWLAQFEATGLDATLY
AWDAPGYGATSNVAVAEPHPEAYADALEAWLDALGLDRVALVGHSLGAIVATKFASRAPHRVRGLFLCSPANGYGRADAE
VRLSKRDSRLAMLDKLGPAGMARERSDNLVAPDAADLPRAWVKWNMSRVLPVGYRQATHLLSNGDVAGELAQYVSAKAGP
VAVAVGAQDGITSPAACEVIANVAGAPLQIIDGAGHASYIETPDVLNAALAAWLERVAAGER

Download         Length: 909 bp

>T53713 NZ_CP011253:1257785-1258693 [Pandoraea oxalativorans]
ATGCAAGCCGAAGCCCATCAACACGAAGCGCCAGAAGACGATGTCGTTGCGTCCTTGCGCGCACGGCTGGACGCGTTTGC
GTACAGCACCGTCGCCACCCGTGCGGGCACCGTCGGCTATCGCTGCGCGGGCGCAGAGCGCGACGCGGGCGTGCCGGTCG
TGATGCTGCACGGCATTGGCTCGGGCGCGGCGTCCTGGCTGGCGCAGTTCGAGGCCACGGGGCTCGATGCAACGCTGTAT
GCCTGGGATGCACCTGGCTATGGCGCGACGTCTAATGTCGCCGTCGCCGAACCGCATCCCGAGGCCTATGCCGACGCCCT
CGAAGCGTGGCTCGACGCCCTGGGTCTGGATCGTGTGGCGCTGGTGGGCCATTCGCTGGGCGCGATCGTGGCGACGAAGT
TTGCAAGCCGCGCCCCGCACCGCGTGCGCGGCCTCTTTCTCTGCTCGCCCGCCAACGGCTACGGCCGCGCGGATGCCGAG
GTGCGCCTGTCCAAGCGCGACAGCCGTCTGGCGATGCTCGACAAGCTCGGCCCCGCAGGCATGGCGCGTGAGCGTAGCGA
CAACCTCGTCGCCCCCGACGCCGCCGATCTGCCGCGTGCGTGGGTGAAATGGAACATGTCGCGGGTGCTGCCCGTCGGCT
ACCGGCAGGCGACGCACCTGCTCTCGAATGGCGACGTCGCTGGCGAACTCGCACAGTACGTGAGCGCCAAGGCCGGTCCC
GTTGCGGTGGCCGTAGGTGCGCAGGACGGCATCACGTCGCCTGCCGCGTGCGAGGTCATTGCGAACGTCGCGGGCGCGCC
GCTGCAAATCATCGACGGCGCGGGTCACGCGTCGTACATCGAAACGCCGGACGTTCTGAATGCTGCGCTCGCCGCGTGGC
TCGAACGTGTCGCGGCAGGGGAGCGCTGA

Antitoxin


Download         Length: 312 a.a.        Molecular weight: 33952.80 Da        Isoelectric Point: 6.9870

>AT53713 WP_084010003.1 NZ_CP011253:1258695-1259630 [Pandoraea oxalativorans]
MAPTARNAPKREALIEDDTMQDDQNASLNGDTVVEGAAESRYLVPGLERGLRILTQFSPREPVFSAPGLSQRLGIPRTTV
FRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQSVA
GVFNSIKVNVGTRLPAHATVHGHVLMGDLTLTELRALYPEKTLEKFTPQTPESLTELFERVREDAERGYAVSASSFERGI
SVVSAPVRNDVGRICAAITVTIPRANIDASMLDAGLIGQVREAADALSHRLNYRPGTDGKSTPYMKSLGLK

Download         Length: 936 bp

>AT53713 NZ_CP011253:1258695-1259630 [Pandoraea oxalativorans]
ATGGCACCGACCGCACGGAACGCACCGAAGCGCGAAGCGCTCATCGAAGACGACACCATGCAGGACGATCAAAACGCTTC
GCTCAACGGCGACACCGTGGTCGAGGGCGCTGCCGAGTCCCGCTATCTCGTGCCGGGACTTGAGCGCGGGTTGCGCATCC
TCACGCAGTTCTCGCCGCGCGAACCGGTGTTCAGTGCACCGGGACTGTCGCAACGGCTGGGCATTCCGCGCACGACGGTC
TTCCGTCTGTTGCAGACGCTCGAAGCGATGGGCTTTCTTGAGCGCGCAGGAAGCGAAAAGAACTTCCGTCTGGGCGTGGC
CGTGCTGCGTCTGGGTTTCGAATACCTCAGTTCGCTGGAACTGACCGACCTCGGCATTCCGATCATCGAGCGCTTGCGCG
ACGCCACCCAACTGACGTCGCACATCGTGATTCGCGACGGCCGGGACATCGTGTTCGTGGCGAAGGCGCAAAGCGTGGCG
GGCGTCTTCAATTCGATCAAGGTCAACGTCGGCACGCGTCTGCCTGCGCACGCCACGGTGCACGGTCACGTGTTGATGGG
CGATCTGACGCTCACCGAACTGCGCGCGCTGTATCCCGAGAAGACGCTGGAGAAATTCACGCCGCAGACGCCCGAATCGC
TCACCGAACTGTTCGAGCGCGTGCGCGAAGACGCCGAGCGCGGCTATGCGGTGTCGGCCTCGTCGTTCGAGCGCGGCATC
AGCGTGGTGAGCGCACCGGTGCGCAACGACGTGGGCCGCATCTGCGCCGCCATTACGGTGACGATTCCGCGCGCCAATAT
CGACGCATCGATGCTCGACGCGGGCCTGATCGGTCAGGTGCGCGAAGCGGCCGATGCGCTCTCGCACCGTCTGAACTACC
GCCCCGGCACCGACGGCAAGTCCACCCCCTACATGAAGTCACTGGGACTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3YG52

Antitoxin

Source ID Structure

References