Detailed information of TA system TA053712

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 126335..126983
• Replicon: chromosome
• Accession: NZ_CP011253
• Organism: Pandoraea oxalativorans strain DSM 23570

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0E3U8Z0
• Locus tag: MB84_RS00535
• Protein ID: WP_046293255.1
• Coordinates: 126564..126983 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MB84_RS00530
• Protein ID: WP_157122597.1
• Coordinates: 126335..126535 (+)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MB84_RS00510	121352..121753	+	402	WP_046290337.1	PaaI family thioesterase	-
MB84_RS00515	121810..122661	+	852	WP_046290338.1	patatin-like phospholipase family protein	-
MB84_RS00520	122728..123738	-	1011	WP_046290339.1	D-2-hydroxyacid dehydrogenase family protein	-
MB84_RS00525	124261..126078	+	1818	WP_157122846.1	phosphoenolpyruvate carboxykinase (GTP)	-
MB84_RS00530	126335..126535	+	201	WP_157122597.1	hypothetical protein	Antitoxin
MB84_RS00535	126564..126983	+	420	WP_046293255.1	type II toxin-antitoxin system VapC family toxin	Toxin
MB84_RS00540	127016..127648	-	633	WP_039394571.1	response regulator transcription factor	-
MB84_RS00545	127645..129033	-	1389	WP_046290342.1	cache domain-containing protein	-
MB84_RS00550	129444..131510	+	2067	WP_046290343.1	carbon starvation protein A	-
MB84_RS00555	131549..131746	+	198	WP_039394580.1	YbdD/YjiX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15770.23 Da
• Isoelectric Point: 10.9574

>T53712 WP_046293255.1 NZ_CP011253:126564-126983 [Pandoraea oxalativorans]
MFLLDTNVVSELRKGGGGDSGVRQFYRHTRSASRRPYLSVITLGELRRGALLLRHRNDLRQAALIENWIGGMHDDFVGHI
LPVDVKISNAWARMRVPHQQDPIDKLIAATALVHRLVVVTRNVKDFSKTGVEVYNPFMQ

Nucleotide

• Length: 420 bp

>T53712 NZ_CP011253:126564-126983 [Pandoraea oxalativorans]
ATGTTCTTGCTCGATACCAACGTAGTTAGTGAACTAAGGAAGGGTGGTGGCGGTGATTCTGGCGTCCGACAGTTTTATCG
TCACACCAGAAGCGCATCCAGGCGCCCCTACCTCTCCGTTATCACCTTGGGGGAATTGCGTCGCGGTGCCTTGCTGCTCC
GCCATCGCAACGATCTTCGTCAGGCGGCGTTGATCGAAAACTGGATTGGGGGCATGCACGACGACTTCGTCGGCCACATT
CTGCCGGTTGACGTGAAGATCAGTAACGCGTGGGCGCGCATGCGCGTGCCGCATCAACAAGATCCGATCGATAAGCTCAT
CGCAGCGACTGCGCTGGTCCACAGACTTGTCGTCGTTACGCGCAACGTCAAGGATTTTTCAAAAACAGGCGTTGAGGTAT
ATAACCCGTTTATGCAATAG

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7780.83 Da
• Isoelectric Point: 4.0548

>AT53712 WP_157122597.1 NZ_CP011253:126335-126535 [Pandoraea oxalativorans]
MMLIEGIDEQLMRSLQLRATQANITPEQEVLRVLNYFAREPEFVDFYDALTRFPNVGLDSDFERIN

Nucleotide

• Length: 201 bp

>AT53712 NZ_CP011253:126335-126535 [Pandoraea oxalativorans]
ATGATGTTGATAGAGGGAATTGATGAGCAACTGATGAGGTCGCTTCAACTGCGCGCGACGCAGGCGAACATAACGCCGGA
GCAGGAGGTGCTGCGCGTGTTGAACTACTTCGCGCGAGAGCCGGAGTTCGTCGATTTTTACGATGCCCTAACGCGTTTCC
CTAACGTGGGGCTCGACAGCGACTTCGAGCGAATCAACTGA

Structures

Toxin

• AlphaFold DB: A0A0E3U8Z0