Detailed information of TA system TA053591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 1442815..1443443
• Replicon: chromosome
• Accession: NZ_CP011163
• Organism: Xanthomonas citri pv. aurantifolii strain FDC 1609

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: TP50_RS06490
• Protein ID: WP_042805622.1
• Coordinates: 1443153..1443443 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: TP50_RS06485
• Protein ID: WP_007972174.1
• Coordinates: 1442815..1443120 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TP50_RS06450	1438561..1438869	+	309	WP_007972180.1	helix-turn-helix domain-containing protein	-
TP50_RS06455	1439094..1439432	+	339	WP_042805627.1	hypothetical protein	-
TP50_RS06460	1439429..1439623	+	195	WP_042805626.1	hypothetical protein	-
TP50_RS06465	1440175..1440474	+	300	WP_042805625.1	hypothetical protein	-
TP50_RS06470	1440471..1441820	+	1350	WP_100084206.1	AAA family ATPase	-
TP50_RS06475	1441810..1442217	+	408	WP_088370866.1	hypothetical protein	-
TP50_RS06480	1442214..1442732	+	519	WP_042805623.1	hypothetical protein	-
TP50_RS06485	1442815..1443120	-	306	WP_007972174.1	putative addiction module antidote protein	Antitoxin
TP50_RS06490	1443153..1443443	-	291	WP_042805622.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TP50_RS06510	1444191..1444847	+	657	WP_007972171.1	glycoside hydrolase family 19 protein	-
TP50_RS06515	1444844..1445347	+	504	WP_007972169.1	hypothetical protein	-
TP50_RS06520	1445344..1445562	+	219	WP_042805621.1	hypothetical protein	-
TP50_RS06525	1445721..1446317	+	597	WP_007972167.1	hypothetical protein	-
TP50_RS06530	1446245..1447654	+	1410	WP_100084205.1	SGNH/GDSL hydrolase family protein	-
TP50_RS06535	1447672..1447965	+	294	WP_131438860.1	hypothetical protein	-
TP50_RS24610	1447968..1448132	+	165	WP_162045088.1	hypothetical protein	-
TP50_RS06540	1448129..1448335	+	207	WP_042805619.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1427278..1466875	39597

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-90)

Antitoxin

• Uncharacterized protein HI1420 (6-92)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10502.19 Da
• Isoelectric Point: 10.1771

>T53591 WP_042805622.1 NZ_CP011163:c1443443-1443153 [Xanthomonas citri pv. aurantifolii]
MTTITATEEFTTWLRKLRDSKAKAVIAERVQRVARGLLGDVEPVGGAISELRIHYGPGYRVYFTRRGEEVVILLCGGDKA
TQAKDIKKAQALAAGL

Nucleotide

• Length: 291 bp

>T53591 NZ_CP011163:c1443443-1443153 [Xanthomonas citri pv. aurantifolii]
ATGACGACGATCACCGCCACCGAAGAGTTCACGACTTGGCTGCGCAAGCTGCGCGACTCGAAAGCCAAGGCGGTGATCGC
CGAACGTGTGCAGCGCGTTGCTCGCGGACTTCTCGGCGATGTTGAGCCGGTAGGCGGGGCGATCAGCGAGCTGCGCATCC
ACTACGGGCCCGGATATCGGGTCTACTTCACCCGCCGCGGTGAGGAGGTCGTCATCCTCCTCTGCGGCGGCGACAAGGCC
ACCCAGGCCAAGGACATCAAGAAAGCGCAAGCCCTTGCCGCCGGCCTCTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10816.14 Da
• Isoelectric Point: 4.4287

>AT53591 WP_007972174.1 NZ_CP011163:c1443120-1442815 [Xanthomonas citri pv. aurantifolii]
MTKTTTTPFDPAEYLDDDEAMATYLSEALASGDTDHFQDALQVVARARGMTQIAEAAGLGRESLYKALKPGANPRFDTIQ
RVLTALGVRLSIDPADTVKAA

Nucleotide

• Length: 306 bp

>AT53591 NZ_CP011163:c1443120-1442815 [Xanthomonas citri pv. aurantifolii]
ATGACAAAGACCACCACCACACCGTTCGATCCGGCCGAATACCTCGACGATGACGAGGCCATGGCCACCTACCTCTCCGA
AGCGCTCGCATCGGGCGATACCGATCACTTCCAGGATGCACTGCAGGTCGTGGCGCGCGCGCGCGGCATGACGCAGATTG
CGGAAGCGGCTGGACTTGGCCGGGAGAGCCTTTACAAGGCGCTCAAGCCCGGAGCAAATCCACGTTTCGACACCATCCAG
CGCGTACTGACTGCGCTTGGCGTCCGTCTGAGCATCGACCCGGCCGATACCGTCAAGGCCGCCTGA