Detailed information of TA system TA053588

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 11007..11547
• Replicon: plasmid pXfc38
• Accession: NZ_CP011162
• Organism: Xanthomonas citri pv. aurantifolii strain FDC 1559

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: TP37_RS24015
• Protein ID: WP_157883188.1
• Coordinates: 11007..11315 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: Q3C0B2
• Locus tag: TP37_RS24020
• Protein ID: WP_011345582.1
• Coordinates: 11332..11547 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TP37_RS23985	6816..7100	+	285	WP_017154887.1	hypothetical protein	-
TP37_RS23990	7107..8294	+	1188	WP_088370902.1	zeta toxin family protein	-
TP37_RS23995	8334..8900	-	567	WP_007966097.1	recombinase family protein	-
TP37_RS24610	9151..9594	-	444	WP_123768332.1	hypothetical protein	-
TP37_RS24005	9646..10047	+	402	Protein_13	hypothetical protein	-
TP37_RS24895	10314..10693	-	380	Protein_14	hypothetical protein	-
TP37_RS24015	11007..11315	-	309	WP_157883188.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
TP37_RS24020	11332..11547	-	216	WP_011345582.1	antitoxin MazE family protein	Antitoxin
TP37_RS24025	11795..12127	-	333	Protein_17	hypothetical protein	-
TP37_RS24030	12124..12755	-	632	Protein_18	ParA family protein	-
TP37_RS24040	13231..13917	+	687	WP_007974125.1	DNA-binding protein	-
TP37_RS24045	14077..15051	+	975	WP_007974204.1	recombinase family protein	-
TP37_RS24050	15160..15429	+	270	WP_017158384.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
TP37_RS24055	15416..15697	+	282	WP_042806120.1	type II toxin-antitoxin system YafQ family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..37980	37980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (29-98)

Antitoxin

• Antitoxin MazE-like (7-70)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11327.22 Da
• Isoelectric Point: 9.9579

>T53588 WP_157883188.1 NZ_CP011162:c11315-11007 [Xanthomonas citri pv. aurantifolii]
MWTVSLQGDYGKPRPAPWSFNPTCSPTWKAFVLCPVTSDLRNAAFRVTVEPNPANGLRALSQVMVDKLSTLPRTKISEPF
GRLDDERMKAIDRALLLVVGVI

Nucleotide

• Length: 309 bp

>T53588 NZ_CP011162:c11315-11007 [Xanthomonas citri pv. aurantifolii]
TTGTGGACGGTTTCATTGCAGGGCGACTATGGCAAACCACGTCCTGCCCCTTGGTCGTTCAATCCGACTTGCTCACCGAC
CTGGAAAGCGTTCGTGCTGTGCCCGGTGACAAGCGACCTGCGCAATGCCGCGTTCCGCGTCACCGTGGAACCGAACCCGG
CCAACGGGCTGCGCGCGCTCTCGCAGGTCATGGTGGACAAGCTCTCAACGCTGCCTCGCACCAAGATCAGCGAACCGTTT
GGCCGCCTCGATGATGAGCGGATGAAAGCGATAGACAGGGCGCTCCTGCTGGTCGTTGGCGTTATCTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8190.20 Da
• Isoelectric Point: 7.2801

>AT53588 WP_011345582.1 NZ_CP011162:c11547-11332 [Xanthomonas citri pv. aurantifolii]
MSSIHESKVARHRERMRAAGLRPVQFWVPDTRSPEFAAQVRKQCQNLKGDPAETEVLRFTEEAATHVEGWE

Nucleotide

• Length: 216 bp

>AT53588 NZ_CP011162:c11547-11332 [Xanthomonas citri pv. aurantifolii]
ATGTCATCAATTCACGAATCAAAGGTAGCCCGGCACCGCGAGCGGATGCGCGCTGCGGGGCTACGGCCTGTCCAGTTTTG
GGTGCCCGACACACGCTCTCCCGAGTTCGCGGCGCAAGTGCGCAAGCAGTGCCAAAACCTGAAGGGCGACCCGGCAGAAA
CCGAGGTTTTGCGCTTCACCGAAGAGGCCGCAACGCACGTTGAGGGCTGGGAGTGA

Structures

Antitoxin

• AlphaFold DB: Q3C0B2