Detailed information of TA system TA053586

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 4440818..4441446
• Replicon: chromosome
• Accession: NZ_CP011160
• Organism: Xanthomonas citri pv. aurantifolii strain FDC 1559

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: TP37_RS20215
• Protein ID: WP_042805622.1
• Coordinates: 4440818..4441108 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: TP37_RS20220
• Protein ID: WP_007972174.1
• Coordinates: 4441141..4441446 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TP37_RS20165	4435926..4436132	-	207	WP_042805619.1	hypothetical protein	-
TP37_RS24730	4436129..4436293	-	165	WP_162045088.1	hypothetical protein	-
TP37_RS20170	4436296..4436589	-	294	WP_131438860.1	hypothetical protein	-
TP37_RS20175	4436607..4438016	-	1410	WP_100084205.1	SGNH/GDSL hydrolase family protein	-
TP37_RS20180	4437944..4438474	-	531	WP_162269065.1	hypothetical protein	-
TP37_RS20185	4438699..4438917	-	219	WP_042805621.1	hypothetical protein	-
TP37_RS20190	4438914..4439417	-	504	WP_007972169.1	hypothetical protein	-
TP37_RS20195	4439414..4440070	-	657	WP_007972171.1	glycoside hydrolase family 19 protein	-
TP37_RS20215	4440818..4441108	+	291	WP_042805622.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TP37_RS20220	4441141..4441446	+	306	WP_007972174.1	putative addiction module antidote protein	Antitoxin
TP37_RS20225	4441529..4442047	-	519	WP_042805623.1	hypothetical protein	-
TP37_RS20230	4442044..4442451	-	408	WP_088370866.1	hypothetical protein	-
TP37_RS20235	4442441..4443790	-	1350	WP_100084206.1	AAA family ATPase	-
TP37_RS20240	4443787..4444086	-	300	WP_042805625.1	hypothetical protein	-
TP37_RS20245	4444638..4444832	-	195	WP_042805626.1	hypothetical protein	-
TP37_RS20250	4444829..4445167	-	339	WP_042805627.1	hypothetical protein	-
TP37_RS20255	4445392..4445700	-	309	WP_007972180.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4408612..4458061	49449

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-90)

Antitoxin

• Uncharacterized protein HI1420 (6-92)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10502.19 Da
• Isoelectric Point: 10.1771

>T53586 WP_042805622.1 NZ_CP011160:4440818-4441108 [Xanthomonas citri pv. aurantifolii]
MTTITATEEFTTWLRKLRDSKAKAVIAERVQRVARGLLGDVEPVGGAISELRIHYGPGYRVYFTRRGEEVVILLCGGDKA
TQAKDIKKAQALAAGL

Nucleotide

• Length: 291 bp

>T53586 NZ_CP011160:4440818-4441108 [Xanthomonas citri pv. aurantifolii]
ATGACGACGATCACCGCCACCGAAGAGTTCACGACTTGGCTGCGCAAGCTGCGCGACTCGAAAGCCAAGGCGGTGATCGC
CGAACGTGTGCAGCGCGTTGCTCGCGGACTTCTCGGCGATGTTGAGCCGGTAGGCGGGGCGATCAGCGAGCTGCGCATCC
ACTACGGGCCCGGATATCGGGTCTACTTCACCCGCCGCGGTGAGGAGGTCGTCATCCTCCTCTGCGGCGGCGACAAGGCC
ACCCAGGCCAAGGACATCAAGAAAGCGCAAGCCCTTGCCGCCGGCCTCTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10816.14 Da
• Isoelectric Point: 4.4287

>AT53586 WP_007972174.1 NZ_CP011160:4441141-4441446 [Xanthomonas citri pv. aurantifolii]
MTKTTTTPFDPAEYLDDDEAMATYLSEALASGDTDHFQDALQVVARARGMTQIAEAAGLGRESLYKALKPGANPRFDTIQ
RVLTALGVRLSIDPADTVKAA

Nucleotide

• Length: 306 bp

>AT53586 NZ_CP011160:4441141-4441446 [Xanthomonas citri pv. aurantifolii]
ATGACAAAGACCACCACCACACCGTTCGATCCGGCCGAATACCTCGACGATGACGAGGCCATGGCCACCTACCTCTCCGA
AGCGCTCGCATCGGGCGATACCGATCACTTCCAGGATGCACTGCAGGTCGTGGCGCGCGCGCGCGGCATGACGCAGATTG
CGGAAGCGGCTGGACTTGGCCGGGAGAGCCTTTACAAGGCGCTCAAGCCCGGAGCAAATCCACGTTTCGACACCATCCAG
CGCGTACTGACTGCGCTTGGCGTCCGTCTGAGCATCGACCCGGCCGATACCGTCAAGGCCGCCTGA