Detailed information of TA system TA053584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2346622..2347600
• Replicon: chromosome
• Accession: NZ_CP011155
• Organism: Bacillus cereus strain HN001

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: WR52_RS11870
• Protein ID: WP_000624975.1
• Coordinates: 2346622..2347359 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: M1PKC2
• Locus tag: WR52_RS11875
• Protein ID: WP_000237819.1
• Coordinates: 2347472..2347600 (+)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WR52_RS11840	2342100..2342810	+	711	WP_063536367.1	class I SAM-dependent methyltransferase	-
WR52_RS11845	2342929..2343336	+	408	WP_000072495.1	VOC family protein	-
WR52_RS11850	2343360..2343740	+	381	WP_080470697.1	methyltransferase	-
WR52_RS11855	2343898..2344889	-	992	Protein_2279	hypothetical protein	-
WR52_RS11860	2344997..2345479	+	483	WP_000191888.1	MarR family winged helix-turn-helix transcriptional regulator	-
WR52_RS11865	2345646..2346383	+	738	WP_063536368.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
WR52_RS11870	2346622..2347359	+	738	WP_000624975.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
WR52_RS11875	2347472..2347600	+	129	WP_000237819.1	hypothetical protein	Antitoxin
WR52_RS11880	2347673..2347849	+	177	WP_000852629.1	stage II sporulation protein SB	-
WR52_RS11885	2347869..2348259	-	391	Protein_2285	YxeA family protein	-
WR52_RS11890	2348470..2349939	+	1470	WP_063536369.1	beta-Ala-His dipeptidase	-
WR52_RS30585	2350060..2351402	+	1343	WP_154818483.1	IS3 family transposase	-
WR52_RS11905	2351656..2352465	+	810	WP_063536371.1	C39 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28278.98 Da
• Isoelectric Point: 8.2998

>T53584 WP_000624975.1 NZ_CP011155:2346622-2347359 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMAIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T53584 NZ_CP011155:2346622-2347359 [Bacillus cereus]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGCTATTTTTGTTGATATTGCGTTC
ATTTTAACACCTAATATTTCTGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCCGCGAAAGAGTTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 4953.36 Da
• Isoelectric Point: 3.9798

>AT53584 WP_000237819.1 NZ_CP011155:2347472-2347600 [Bacillus cereus]
VVKDYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS

Nucleotide

• Length: 129 bp

>AT53584 NZ_CP011155:2347472-2347600 [Bacillus cereus]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGGTAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Structures

Antitoxin

• AlphaFold DB: M1PKC2