Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 851514..851991 Replicon chromosome
Accession NZ_CP011147
Organism Staphylococcus aureus strain FCFHV36

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FCFHV36_RS04065 Protein ID WP_000052076.1
Coordinates 851514..851702 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FCFHV36_RS04070 Protein ID WP_001059690.1
Coordinates 851731..851991 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCFHV36_RS04035 847508..848029 + 522 WP_000824482.1 hypothetical protein -
FCFHV36_RS04040 848370..849056 + 687 WP_000141557.1 thermonuclease family protein -
FCFHV36_RS04045 849413..849613 + 201 WP_001059082.1 cold-shock protein -
FCFHV36_RS04050 850105..850323 - 219 WP_000005886.1 hypothetical protein -
FCFHV36_RS04055 850400..850669 - 270 WP_001004398.1 hypothetical protein -
FCFHV36_RS04060 850757..851326 - 570 WP_001106658.1 hypothetical protein -
FCFHV36_RS04065 851514..851702 - 189 WP_000052076.1 hypothetical protein Toxin
FCFHV36_RS04070 851731..851991 - 261 WP_001059690.1 hypothetical protein Antitoxin
FCFHV36_RS04075 852332..852535 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FCFHV36_RS04080 852532..852768 - 237 WP_000349581.1 hypothetical protein -
FCFHV36_RS04085 852993..853574 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
FCFHV36_RS04090 853647..854264 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
FCFHV36_RS04095 854419..854913 - 495 WP_000569883.1 GNAT family N-acetyltransferase -
FCFHV36_RS04100 855312..855734 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FCFHV36_RS04105 855882..856598 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T53561 WP_000052076.1 NZ_CP011147:c851702-851514 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T53561 NZ_CP011147:c851702-851514 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT53561 WP_001059690.1 NZ_CP011147:c851991-851731 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT53561 NZ_CP011147:c851991-851731 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References