Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3339876..3340671 | Replicon | chromosome |
| Accession | NZ_CP011134 | ||
| Organism | Escherichia coli VR50 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A4Y9BN12 |
| Locus tag | ECVR50_RS16695 | Protein ID | WP_023909482.1 |
| Coordinates | 3340297..3340671 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | ECVR50_RS16690 | Protein ID | WP_001522275.1 |
| Coordinates | 3339876..3340250 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECVR50_RS16660 | 3335038..3335856 | + | 819 | WP_001522287.1 | DUF945 domain-containing protein | - |
| ECVR50_RS30350 | 3335856..3336032 | + | 177 | WP_001522285.1 | hypothetical protein | - |
| ECVR50_RS16665 | 3336127..3336600 | + | 474 | WP_001522284.1 | antirestriction protein | - |
| ECVR50_RS16670 | 3336615..3337091 | + | 477 | WP_001186724.1 | RadC family protein | - |
| ECVR50_RS16675 | 3337272..3338771 | + | 1500 | WP_001522281.1 | IS21-like element ISEc10 family transposase | - |
| ECVR50_RS16680 | 3338768..3339523 | + | 756 | WP_001522280.1 | IS21-like element ISEc10 family helper ATPase IstB | - |
| ECVR50_RS16685 | 3339575..3339796 | + | 222 | WP_023909484.1 | DUF987 domain-containing protein | - |
| ECVR50_RS16690 | 3339876..3340250 | + | 375 | WP_001522275.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| ECVR50_RS16695 | 3340297..3340671 | + | 375 | WP_023909482.1 | TA system toxin CbtA family protein | Toxin |
| ECVR50_RS16700 | 3340668..3341159 | + | 492 | WP_001522269.1 | hypothetical protein | - |
| ECVR50_RS16705 | 3341171..3341368 | + | 198 | WP_001522268.1 | DUF957 domain-containing protein | - |
| ECVR50_RS16710 | 3341453..3342319 | + | 867 | WP_001522267.1 | DUF4942 domain-containing protein | - |
| ECVR50_RS16715 | 3342391..3342654 | + | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| ECVR50_RS16720 | 3342651..3342977 | + | 327 | WP_001522265.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| ECVR50_RS16725 | 3343441..3344706 | + | 1266 | WP_001218878.1 | integrase arm-type DNA-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | draP / afaD / afaC-I / afaB-I / afaA / papX / papA / papI / sat / iutA / iucD / iucC / iucB / iucA / kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / neuE / neuC / neuA / neuB / neuD / kpsT / kpsM / gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 3297487..3499887 | 202400 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14009.98 Da Isoelectric Point: 8.2905
>T53545 WP_023909482.1 NZ_CP011134:3340297-3340671 [Escherichia coli VR50]
MKTLSDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRTVNNITQGKHPEAK
MKTLSDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRTVNNITQGKHPEAK
Download Length: 375 bp
>T53545 NZ_CP011134:3340297-3340671 [Escherichia coli VR50]
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCGAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13630.35 Da Isoelectric Point: 5.5051
>AT53545 WP_001522275.1 NZ_CP011134:3339876-3340250 [Escherichia coli VR50]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT53545 NZ_CP011134:3339876-3340250 [Escherichia coli VR50]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGATGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCGGTTTATCCGACACCGGCACCCGCAACCACCTCATAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGATGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCGGTTTATCCGACACCGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|