Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 15331..15881 Replicon plasmid unnamed
Accession NZ_CP011133
Organism Citrobacter amalonaticus Y19

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0F6TZV8
Locus tag F384_RS26230 Protein ID WP_046498752.1
Coordinates 15331..15639 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0F6RIT5
Locus tag F384_RS26235 Protein ID WP_046498757.1
Coordinates 15642..15881 (-) Length 80 a.a.

Genomic Context

F384_RS26185F384_RS26190F384_RS26195F384_RS26200F384_RS26205F384_RS26210F384_RS26215F384_RS26220F384_RS26225F384_RS30200F384_RS26230F384_RS26235F384_RS30245F384_RS26245F384_RS26250F384_RS26255F384_RS26260
Location: 10390..10728 (339 bp)
Type: Others
Protein ID: WP_046498719.1
Location: 10953..11264 (312 bp)
Type: Others
Protein ID: WP_046498724.1
Location: 11304..11612 (309 bp)
Type: Others
Protein ID: WP_046498729.1
Location: 11976..12302 (327 bp)
Type: Others
Protein ID: WP_046498732.1
Location: 12387..12785 (399 bp)
Type: Others
Protein ID: WP_046498736.1
Location: 12796..13038 (243 bp)
Type: Others
Protein ID: WP_046499465.1
Location: 13248..13670 (423 bp)
Type: Others
Protein ID: Protein_21
Location: 13753..14370 (618 bp)
Type: Others
Protein ID: WP_046498741.1
Location: 14443..14997 (555 bp)
Type: Others
Protein ID: WP_046498747.1
Location: 15152..15307 (156 bp)
Type: Others
Protein ID: WP_167337386.1
Location: 15331..15639 (309 bp)
Type: Toxin
Protein ID: WP_046498752.1
Location: 15642..15881 (240 bp)
Type: Antitoxin
Protein ID: WP_046498757.1
Location: 16021..16485 (465 bp)
Type: Others
Protein ID: WP_193388325.1
Location: 16482..17153 (672 bp)
Type: Others
Protein ID: WP_046498763.1
Location: 17614..18255 (642 bp)
Type: Others
Protein ID: WP_046498769.1
Location: 18559..19017 (459 bp)
Type: Others
Protein ID: WP_046498772.1
Location: 19290..19985 (696 bp)
Type: Others
Protein ID: WP_046498775.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
F384_RS2618510390..10728+339WP_046498719.1hypothetical protein-
F384_RS2619010953..11264+312WP_046498724.1hypothetical protein-
F384_RS2619511304..11612+309WP_046498729.1hypothetical protein-
F384_RS2620011976..12302-327WP_046498732.1hypothetical protein-
F384_RS2620512387..12785-399WP_046498736.1hypothetical protein-
F384_RS2621012796..13038-243WP_046499465.1hypothetical protein-
F384_RS2621513248..13670-423Protein_21hypothetical protein-
F384_RS2622013753..14370-618WP_046498741.1hypothetical protein-
F384_RS2622514443..14997-555WP_046498747.1hypothetical protein-
F384_RS3020015152..15307-156WP_167337386.1hypothetical protein-
F384_RS2623015331..15639-309WP_046498752.1CcdB family proteinToxin
F384_RS2623515642..15881-240WP_046498757.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
F384_RS3024516021..16485-465WP_193388325.1hypothetical protein-
F384_RS2624516482..17153-672WP_046498763.1hypothetical protein-
F384_RS2625017614..18255-642WP_046498769.1hypothetical protein-
F384_RS2625518559..19017-459WP_046498772.1hypothetical protein-
F384_RS2626019290..19985-696WP_046498775.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..290993290993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11282.11 Da        Isoelectric Point: 7.3147

>T53528 WP_046498752.1 NZ_CP011133:c15639-15331 [Citrobacter amalonaticus Y19]
MQYTVYRNTGNSQAYPYLLDIQSDIIGELNTRLVIPLHLLKKGASAPVARLTPVIQVEGNDVILMTHEMASVRVKQLGQA
VMDASPFRHTIKGAVDFLLDGF

Download         Length: 309 bp

>T53528 NZ_CP011133:c15639-15331 [Citrobacter amalonaticus Y19]
ATGCAATACACCGTTTACCGCAATACCGGCAATAGCCAGGCATATCCTTACCTGCTGGATATACAGAGCGACATCATTGG
TGAGTTGAATACCCGTCTGGTGATCCCGCTTCATCTGCTGAAAAAAGGAGCCTCGGCCCCGGTTGCGCGGTTAACTCCGG
TTATTCAGGTGGAAGGGAATGACGTTATCCTGATGACACATGAAATGGCCTCGGTTCGCGTGAAGCAGCTTGGTCAGGCG
GTCATGGATGCATCTCCGTTCCGGCACACTATCAAAGGCGCTGTGGACTTCCTGCTGGATGGTTTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8843.01 Da        Isoelectric Point: 8.6598

>AT53528 WP_046498757.1 NZ_CP011133:c15881-15642 [Citrobacter amalonaticus Y19]
MQTTAARQKKTVSVTLEPMLVQQARDAGINLSATLAEALQSKLKASAAEEWKRQNRAGIQELNRITEEHGLLSDEYRTF

Download         Length: 240 bp

>AT53528 NZ_CP011133:c15881-15642 [Citrobacter amalonaticus Y19]
ATGCAGACTACAGCTGCTCGCCAGAAAAAAACCGTCAGTGTCACTCTTGAGCCAATGCTTGTACAGCAGGCAAGAGACGC
TGGGATTAACTTGTCCGCCACGCTGGCAGAAGCGCTTCAGAGCAAACTGAAGGCCAGTGCTGCGGAAGAATGGAAACGAC
AGAATCGTGCTGGTATTCAGGAGTTGAACCGCATCACTGAAGAGCATGGGTTACTGTCTGACGAATACAGGACGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F6TZV8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F6RIT5

References