Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 6920..7815 Replicon plasmid unnamed
Accession NZ_CP011133
Organism Citrobacter amalonaticus Y19

Toxin (Protein)


Gene name - Uniprot ID A0A0F6RII6
Locus tag F384_RS26155 Protein ID WP_046498702.1
Coordinates 7357..7815 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0F6RIU7
Locus tag F384_RS26150 Protein ID WP_046499459.1
Coordinates 6920..7360 (+) Length 147 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F384_RS26125 2944..3852 - 909 WP_080950118.1 HNH endonuclease -
F384_RS30195 4359..4523 - 165 WP_167337385.1 hypothetical protein -
F384_RS26130 4809..5252 - 444 WP_046498679.1 hypothetical protein -
F384_RS26135 5313..5591 - 279 WP_046498685.1 hypothetical protein -
F384_RS26140 5563..6405 - 843 WP_046498690.1 hypothetical protein -
F384_RS26145 6447..6764 - 318 WP_046498696.1 hypothetical protein -
F384_RS26150 6920..7360 + 441 WP_046499459.1 DUF2384 domain-containing protein Antitoxin
F384_RS26155 7357..7815 + 459 WP_046498702.1 RES family NAD+ phosphorylase Toxin
F384_RS26160 7858..8088 + 231 WP_046498706.1 hypothetical protein -
F384_RS26165 8156..8422 - 267 WP_046498709.1 hypothetical protein -
F384_RS26170 8715..9089 - 375 Protein_12 hypothetical protein -
F384_RS26175 9248..9589 - 342 WP_046498712.1 hypothetical protein -
F384_RS26180 9709..10152 - 444 WP_046498716.1 hypothetical protein -
F384_RS26185 10390..10728 + 339 WP_046498719.1 hypothetical protein -
F384_RS26190 10953..11264 + 312 WP_046498724.1 hypothetical protein -
F384_RS26195 11304..11612 + 309 WP_046498729.1 hypothetical protein -
F384_RS26200 11976..12302 - 327 WP_046498732.1 hypothetical protein -
F384_RS26205 12387..12785 - 399 WP_046498736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..290993 290993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(93-143)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16986.43 Da        Isoelectric Point: 4.5594

>T53527 WP_046498702.1 NZ_CP011133:7357-7815 [Citrobacter amalonaticus Y19]
VILYRLTKTRYLMTAWSGLGAKEAGGRWNSVGTAMVYLSEAASLTMLETLVHINAPQLLDDFTLLSLDVPDEQIQTFDMN
LLPDNWASQDAPAELAHYGDSWVESGSSIALRIPSALSPVEFNYLLNPAHPELFELMATVRKIPFRFDSRLK

Download         Length: 459 bp

>T53527 NZ_CP011133:7357-7815 [Citrobacter amalonaticus Y19]
GTGATCCTTTACCGTTTGACCAAGACTCGTTATCTGATGACTGCGTGGTCTGGTCTGGGTGCAAAAGAAGCGGGGGGCCG
CTGGAACAGCGTTGGCACAGCAATGGTCTACCTGTCCGAAGCGGCCTCCCTTACCATGCTTGAAACGCTGGTACACATTA
ACGCACCGCAGCTACTGGACGACTTTACCCTGCTGAGTCTCGATGTACCGGATGAACAGATCCAGACATTCGACATGAAC
CTGCTTCCTGATAACTGGGCAAGTCAGGATGCTCCTGCCGAGCTGGCGCACTACGGTGATAGCTGGGTTGAAAGCGGTTC
TTCAATCGCGCTACGTATCCCCAGTGCGCTGTCTCCGGTTGAATTCAACTACCTGCTGAATCCCGCTCACCCTGAACTCT
TTGAACTGATGGCTACCGTCAGGAAAATTCCGTTCCGGTTTGATTCGCGCCTGAAATAA

Antitoxin


Download         Length: 147 a.a.        Molecular weight: 16460.73 Da        Isoelectric Point: 6.9812

>AT53527 WP_046499459.1 NZ_CP011133:6920-7360 [Citrobacter amalonaticus Y19]
MKVFSPDVTKSNQHCLWQVVGLDNDGIGLMDKINHGLDGTVAKHISEWANITPSELRKMSGIPNTTFNRSIKDRFTADQS
ERLVRIIRVIERAVELFEGDKEAAHKWMNEANRGLSWKSPAEVVSSETGALEVMRLITRIEHGVYS

Download         Length: 441 bp

>AT53527 NZ_CP011133:6920-7360 [Citrobacter amalonaticus Y19]
ATGAAAGTTTTTTCTCCAGACGTGACCAAATCGAACCAGCACTGCTTATGGCAGGTTGTTGGTCTGGACAATGACGGTAT
CGGGCTGATGGACAAAATCAATCACGGTCTCGATGGCACAGTAGCTAAGCACATTTCGGAATGGGCTAACATCACGCCGT
CTGAACTGCGCAAAATGTCGGGCATACCGAATACGACGTTTAATCGTAGCATCAAAGACCGTTTCACTGCCGATCAGAGC
GAACGTCTGGTGCGCATTATCCGCGTCATTGAACGTGCTGTAGAGCTGTTTGAAGGTGACAAAGAAGCAGCGCACAAATG
GATGAACGAAGCGAACCGTGGTCTGAGCTGGAAATCACCGGCAGAGGTTGTTTCTTCTGAGACTGGTGCGCTCGAAGTTA
TGCGCCTGATTACGCGTATTGAGCACGGGGTATATTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6RII6

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6RIU7

References