Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 4963207..4963991 Replicon chromosome
Accession NZ_CP011132
Organism Citrobacter amalonaticus Y19

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0F6RHU9
Locus tag F384_RS23020 Protein ID WP_046494067.1
Coordinates 4963497..4963991 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A0F6TYL2
Locus tag F384_RS23015 Protein ID WP_046494064.1
Coordinates 4963207..4963500 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F384_RS22995 4960394..4961020 + 627 WP_046494056.1 dimethylsulfoxide reductase subunit B -
F384_RS23000 4961013..4961786 + 774 WP_046494058.1 dimethyl sulfoxide reductase anchor subunit -
F384_RS23005 4961870..4962466 + 597 WP_046494060.1 molecular chaperone -
F384_RS23010 4962463..4962996 + 534 WP_046494062.1 ferredoxin-type protein NapF -
F384_RS23015 4963207..4963500 + 294 WP_046494064.1 DUF1778 domain-containing protein Antitoxin
F384_RS23020 4963497..4963991 + 495 WP_046494067.1 GNAT family N-acetyltransferase Toxin
F384_RS23025 4964400..4964930 + 531 WP_046494070.1 type 1 fimbrial protein -
F384_RS23030 4964983..4965555 + 573 WP_155404030.1 type 1 fimbrial protein -
F384_RS23035 4965619..4968093 + 2475 WP_046494072.1 fimbria/pilus outer membrane usher protein -
F384_RS23040 4968166..4968879 + 714 WP_155404031.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18004.07 Da        Isoelectric Point: 8.1347

>T53525 WP_046494067.1 NZ_CP011132:4963497-4963991 [Citrobacter amalonaticus Y19]
MISAPQPLEMKHQLATFRCGIASMDNWLKQRAMKNQTTGASRTFVCCENDSVCAYYSLASSAVMMVDAPVGFRRNMPDPI
PVVILGRLAVDTSLQGQGIGRALVRDAGMRIIHVAETIGIRGLLVHALSNEAREFYLRVGFEPSPMDPMMLLATLKDLQA
SLSY

Download         Length: 495 bp

>T53525 NZ_CP011132:4963497-4963991 [Citrobacter amalonaticus Y19]
ATGATCTCTGCGCCACAACCGCTTGAGATGAAACATCAACTGGCGACATTTCGTTGTGGTATTGCCTCCATGGATAACTG
GCTTAAACAACGGGCAATGAAAAACCAGACGACCGGAGCTTCGCGAACGTTTGTTTGCTGCGAAAATGATTCTGTCTGTG
CCTATTATTCGCTGGCTTCCAGTGCGGTGATGATGGTCGATGCGCCAGTCGGGTTCCGACGTAACATGCCCGATCCCATT
CCTGTCGTGATATTAGGTCGTCTGGCCGTTGATACCTCGCTTCAAGGACAAGGAATTGGCCGAGCGTTGGTCCGTGATGC
CGGAATGCGGATTATCCATGTTGCCGAAACAATAGGTATTCGTGGGTTGTTAGTTCATGCCTTGTCGAATGAAGCCAGAG
AGTTCTATCTTCGTGTCGGTTTTGAACCCTCACCAATGGACCCGATGATGTTACTGGCGACGTTAAAAGATTTGCAGGCA
AGTCTTTCATACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11010.75 Da        Isoelectric Point: 10.2615

>AT53525 WP_046494064.1 NZ_CP011132:4963207-4963500 [Citrobacter amalonaticus Y19]
MPPKTHVPVKRETLNLRISPVERELIDRAAKVRGKNRTDFVLDAARAAAEEALLEHRIIMVDPARYQDFLARLDASPVPN
AALRETMQTPAPWEKTK

Download         Length: 294 bp

>AT53525 NZ_CP011132:4963207-4963500 [Citrobacter amalonaticus Y19]
ATGCCCCCAAAAACTCACGTCCCGGTGAAGCGCGAAACGCTGAATTTGCGCATTAGCCCCGTGGAACGCGAACTCATTGA
TCGTGCCGCGAAGGTCAGAGGCAAAAATCGCACTGACTTTGTCTTAGATGCTGCACGCGCAGCAGCAGAGGAAGCGTTGC
TTGAACATCGCATTATCATGGTTGATCCTGCCCGCTATCAGGATTTTTTGGCGCGACTTGATGCGTCCCCAGTGCCGAAT
GCAGCTTTACGTGAGACGATGCAAACTCCTGCACCATGGGAAAAGACGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6RHU9

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TYL2

References