53523

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3476066..3476720 Replicon chromosome
Accession NZ_CP011132
Organism Citrobacter amalonaticus Y19

Toxin (Protein)


Gene name cptA Uniprot ID A0A0F6RG37
Locus tag F384_RS15955 Protein ID WP_046486944.1
Coordinates 3476066..3476473 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag F384_RS15960 Protein ID WP_042322123.1
Coordinates 3476454..3476720 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F384_RS15935 3471987..3473720 - 1734 WP_046486934.1 single-stranded-DNA-specific exonuclease RecJ -
F384_RS15940 3473726..3474439 - 714 WP_046486937.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F384_RS15945 3474463..3475359 - 897 WP_046498264.1 site-specific tyrosine recombinase XerD -
F384_RS15950 3475460..3475981 + 522 WP_046486940.1 flavodoxin FldB -
F384_RS15955 3476066..3476473 - 408 WP_046486944.1 protein YgfX Toxin
F384_RS15960 3476454..3476720 - 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
F384_RS15965 3476977..3477957 + 981 WP_046486952.1 tRNA-modifying protein YgfZ -
F384_RS15970 3478315..3478974 - 660 WP_046486956.1 hemolysin III family protein -
F384_RS15975 3479137..3479448 - 312 WP_046486963.1 N(4)-acetylcytidine aminohydrolase -
F384_RS15980 3479500..3480228 + 729 WP_046486968.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15835.76 Da        Isoelectric Point: 11.1911

>T53523 WP_046486944.1 NZ_CP011132:c3476473-3476066 [Citrobacter amalonaticus Y19]
VVLWQSDLRVSWRAQWLSLLLHGLVAAVILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGH
DWLIVSAPWMISTGMMLRLRSETGKRQHLWLAADSMDDAEWRDLRRLMMQTSTLG

Download         Length: 408 bp

>T53523 NZ_CP011132:c3476473-3476066 [Citrobacter amalonaticus Y19]
GTGGTCCTGTGGCAATCTGATCTCCGCGTCTCATGGCGCGCACAATGGCTATCGCTACTCCTGCATGGGCTGGTGGCGGC
GGTTATTCTATTAATGCCATGGCCTCTGAGCTACACGCCGCTGTGGTTGATACTACTTTCGCTGGTTGTGTTTGACTGTG
TTCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGAGAGGTTAAACTTCTGATGGACGGACGGCTCCGCTGGCAGGGGCAT
GACTGGCTTATCGTCAGTGCACCGTGGATGATCAGCACCGGCATGATGCTGCGTTTGCGTTCTGAGACCGGTAAACGCCA
GCATTTGTGGCTCGCGGCAGACAGTATGGACGACGCTGAATGGCGGGATTTACGCCGCCTGATGATGCAAACGTCGACGC
TGGGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT53523 WP_042322123.1 NZ_CP011132:c3476720-3476454 [Citrobacter amalonaticus Y19]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT53523 NZ_CP011132:c3476720-3476454 [Citrobacter amalonaticus Y19]
ATGGATATTAACAATAAAGCACGTATTCACTGGGCATGCCGACGCGGTATGCGTGAACTCGATATTTCCATCATGCCGTT
TTTCGAACATGAGTACGACACGTTGAGCGATGATGAAAAACGTATTTTTATTCGTCTGCTGGAGTGTGATGACCCGGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCAGATGCTGAACTGGAGCAGATGGTACGACTCATTCAGACACGGAAT
CGGGATCGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6RG37

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References