Detailed information of TA system TA053511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1061957..1062776
• Replicon: chromosome
• Accession: NZ_CP011132
• Organism: Citrobacter amalonaticus Y19

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: D2ZA45
• Locus tag: F384_RS04770
• Protein ID: WP_006174186.1
• Coordinates: 1061957..1062214 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: F384_RS04775
• Protein ID: WP_046478809.1
• Coordinates: 1062225..1062776 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F384_RS04750	1058394..1059299	-	906	WP_155403975.1	dihydrodipicolinate synthase family protein	-
F384_RS04755	1059304..1060092	-	789	WP_046478802.1	IclR family transcriptional regulator	-
F384_RS04760	1060330..1061121	+	792	WP_046478804.1	PhzF family phenazine biosynthesis protein	-
F384_RS04765	1061206..1061598	+	393	WP_046478805.1	VOC family protein	-
F384_RS04770	1061957..1062214	+	258	WP_006174186.1	YjhX family toxin	Toxin
F384_RS04775	1062225..1062776	+	552	WP_046478809.1	N-acetyltransferase	Antitoxin
F384_RS04780	1062828..1063574	+	747	WP_046478811.1	class I SAM-dependent methyltransferase	-
F384_RS04785	1064127..1064687	+	561	WP_046478813.1	hypothetical protein	-
F384_RS04790	1065288..1066148	+	861	WP_046478814.1	AraC family transcriptional regulator	-
F384_RS04795	1066212..1067732	-	1521	WP_080949873.1	carbohydrate porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (20-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9520.03 Da
• Isoelectric Point: 11.1381

>T53511 WP_006174186.1 NZ_CP011132:1061957-1062214 [Citrobacter amalonaticus Y19]
MNLSRQEQRTLHVLAKGGRIAHVRDTSGRVTAVECYSREGLLLADCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QPDNR

Nucleotide

• Length: 258 bp

>T53511 NZ_CP011132:1061957-1062214 [Citrobacter amalonaticus Y19]
ATGAATTTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCCAAAGGTGGACGTATTGCGCACGTCCGCGATACGTC
CGGCCGCGTCACCGCCGTTGAATGCTACAGCCGCGAAGGACTGCTGCTCGCCGACTGCACACTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAGCTGATCAAATCCGTCAATGGTCAACCCTACCGCATTAACACCACCGGGCTGAATAACGTTCGCGCC
CAGCCAGATAACCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20490.38 Da
• Isoelectric Point: 6.4932

>AT53511 WP_046478809.1 NZ_CP011132:1062225-1062776 [Citrobacter amalonaticus Y19]
MTTHNFTFHITDERDAGDIREVETRAFGYGKEAELVASLLEDESARPTLSLLARHEGKAVGHILFTRATFKGEMESPLMH
ILAPLAVIPEYQGRGVGGLLIRTGLAHLRLMGCQRVFVLGHATYYPRHGFEPYAGDNGYPAPYPIPDEHKACWMMQSLSA
QPFDRAGDIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT53511 NZ_CP011132:1062225-1062776 [Citrobacter amalonaticus Y19]
ATGACAACGCACAACTTCACTTTTCATATCACCGATGAACGTGATGCAGGCGACATCCGGGAAGTCGAAACCCGTGCATT
TGGCTACGGCAAAGAGGCTGAACTGGTGGCTTCTTTACTGGAGGATGAAAGTGCACGTCCGACGTTATCGTTGCTGGCCA
GACATGAAGGTAAAGCCGTCGGGCATATCTTGTTCACCCGGGCGACATTCAAGGGGGAAATGGAATCTCCCCTGATGCAT
ATCCTCGCGCCTCTGGCGGTCATACCGGAATACCAGGGGAGAGGCGTGGGGGGATTGTTGATACGCACCGGCTTAGCGCA
CTTACGGTTGATGGGATGCCAGCGCGTTTTTGTTCTCGGTCATGCCACTTACTATCCGCGACATGGATTCGAACCTTACG
CAGGAGACAACGGCTATCCCGCGCCTTATCCCATCCCGGACGAGCATAAGGCCTGCTGGATGATGCAGTCCCTCTCTGCA
CAACCCTTTGATCGTGCCGGCGACATCCAGTGTGCGCAGGCCTTAATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: A0A0F6TU16