Detailed information of TA system TA053508

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParST/RES-Xre
• Location: 3395978..3396833
• Replicon: chromosome
• Accession: NZ_CP011129
• Organism: Lysobacter antibioticus strain 76

Toxin (Protein)

• Gene name: ParT
• Uniprot ID: -
• Locus tag: LA76x_RS13445
• Protein ID: WP_057918208.1
• Coordinates: 3396357..3396833 (+)
• Length: 159 a.a.

Antitoxin (Protein)

• Gene name: ParS
• Uniprot ID: -
• Locus tag: LA76x_RS25170
• Protein ID: WP_144436723.1
• Coordinates: 3395978..3396322 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA76x_RS13405	3390978..3391589	-	612	WP_082647881.1	GNAT family N-acetyltransferase	-
LA76x_RS13410	3391696..3392529	+	834	WP_148649738.1	universal stress protein	-
LA76x_RS13415	3392599..3392868	-	270	WP_057918204.1	hypothetical protein	-
LA76x_RS13420	3393135..3393521	-	387	WP_057918205.1	hypothetical protein	-
LA76x_RS13425	3393731..3393931	-	201	WP_148649739.1	hypothetical protein	-
LA76x_RS13430	3394214..3394657	-	444	WP_057918207.1	hypothetical protein	-
LA76x_RS13435	3394954..3395460	-	507	WP_082647882.1	GNAT family N-acetyltransferase	-
LA76x_RS25170	3395978..3396322	+	345	WP_144436723.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
LA76x_RS13445	3396357..3396833	+	477	WP_057918208.1	RES family NAD+ phosphorylase	Toxin
LA76x_RS13450	3396950..3397678	-	729	WP_057918209.1	DUF4166 domain-containing protein	-
LA76x_RS13455	3397644..3399215	-	1572	WP_057918210.1	TIGR01777 family oxidoreductase	-
LA76x_RS13460	3399229..3399666	-	438	WP_057918211.1	DUF393 domain-containing protein	-
LA76x_RS13465	3399722..3400399	-	678	WP_082647883.1	GbsR/MarR family transcriptional regulator	-
LA76x_RS13470	3400780..3401478	+	699	WP_057918212.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-143)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (66-111)

Sequences

Toxin

Protein

• Length: 159 a.a.
• Molecular weight: 17250.70 Da
• Isoelectric Point: 10.0861

>T53508 WP_057918208.1 NZ_CP011129:3396357-3396833 [Lysobacter antibioticus]
MKLWRIATETRAYRADDLSGAGAAARPGRWNDDGQRVLYTATSLALAALETAAYVDAHGLPLNRHVVSIDVPAAVWKARL
QLSPQELPGAWDAVPAGMASVRVGSQWLASQASAILLVPSVIVPEEYNALINPEHRDARKLRATTGRRFHYNVLFRVA

Nucleotide

• Length: 477 bp

>T53508 NZ_CP011129:3396357-3396833 [Lysobacter antibioticus]
ATGAAACTCTGGCGCATCGCCACCGAAACCCGCGCCTATCGCGCCGACGATCTCAGCGGCGCCGGCGCGGCCGCGCGTCC
CGGGCGTTGGAACGACGACGGCCAGCGGGTGCTCTACACCGCCACCTCATTGGCGCTGGCGGCGCTGGAAACCGCGGCCT
ATGTCGATGCACACGGCCTGCCCTTGAACCGGCACGTGGTGTCGATCGACGTGCCCGCCGCGGTTTGGAAGGCGCGCCTG
CAGCTGTCGCCGCAGGAACTGCCGGGCGCCTGGGACGCGGTGCCCGCCGGCATGGCCAGCGTGCGCGTGGGTTCGCAATG
GCTGGCGAGCCAGGCCTCGGCGATTCTGTTAGTGCCGTCGGTGATCGTGCCGGAGGAATACAACGCCCTGATCAATCCCG
AGCACCGCGACGCCAGGAAACTGCGCGCGACCACCGGCCGGCGCTTCCACTACAACGTGTTGTTCCGGGTGGCCTGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 11827.57 Da
• Isoelectric Point: 6.2992

>AT53508 WP_144436723.1 NZ_CP011129:3395978-3396322 [Lysobacter antibioticus]
MAASMELPAVRMFNILGIAKATAESKAAQQARIAGASGQAALGIMRLLGITEAIVDASTAEGARGFDSAKWLGRWIEQPQ
PALGGRKPADLLDTPTGFDVVARLLGSLESGSYQ

Nucleotide

• Length: 345 bp

>AT53508 NZ_CP011129:3395978-3396322 [Lysobacter antibioticus]
ATGGCCGCGAGCATGGAGCTGCCGGCCGTGCGCATGTTCAACATCCTCGGCATCGCCAAGGCCACCGCCGAAAGCAAGGC
CGCGCAACAGGCGCGCATCGCCGGCGCCAGCGGCCAGGCCGCGCTCGGCATCATGCGCTTGCTCGGCATCACCGAGGCCA
TCGTCGACGCGAGCACGGCCGAAGGCGCGCGCGGCTTCGATTCGGCCAAGTGGCTGGGGCGCTGGATCGAGCAGCCGCAG
CCCGCGCTCGGCGGCCGCAAGCCGGCCGATCTGCTCGACACCCCGACCGGCTTCGACGTCGTCGCGCGTTTGCTCGGCTC
GCTCGAAAGCGGCTCCTACCAGTGA