Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 160690..161275 Replicon plasmid unnamed1
Accession NZ_CP011121
Organism Acetobacter oryzifermentans strain SLV-7

Toxin (Protein)


Gene name mazF Uniprot ID C7JIK9
Locus tag WG31_RS14035 Protein ID WP_012813213.1
Coordinates 160946..161275 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID C7JIL0
Locus tag WG31_RS14030 Protein ID WP_006115554.1
Coordinates 160690..160944 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WG31_RS14000 155773..156792 - 1020 WP_006115550.1 cytochrome d ubiquinol oxidase subunit II -
WG31_RS14005 156795..158228 - 1434 WP_006115551.1 cytochrome ubiquinol oxidase subunit I -
WG31_RS14010 158664..159623 - 960 WP_035350857.1 IS481 family transposase -
WG31_RS14015 159681..159941 + 261 Protein_160 hypothetical protein -
WG31_RS14020 160014..160286 + 273 WP_006115552.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
WG31_RS14025 160283..160591 + 309 WP_006115553.1 PIN domain-containing protein -
WG31_RS14030 160690..160944 + 255 WP_006115554.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WG31_RS14035 160946..161275 + 330 WP_012813213.1 endoribonuclease MazF Toxin
WG31_RS14040 161332..161532 + 201 WP_012813212.1 hypothetical protein -
WG31_RS14045 161562..161882 + 321 WP_012813211.1 hypothetical protein -
WG31_RS14050 161939..162343 - 405 WP_006115557.1 hypothetical protein -
WG31_RS14055 162356..163171 - 816 WP_006115558.1 hypothetical protein -
WG31_RS14060 163268..163732 - 465 WP_039891560.1 hypothetical protein -
WG31_RS14065 163735..164583 - 849 WP_039891563.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..165374 165374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-107)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11925.77 Da        Isoelectric Point: 9.1225

>T53474 WP_012813213.1 NZ_CP011121:160946-161275 [Acetobacter oryzifermentans]
MVAYVPDAGEIVWLDFSPQIGHEQAGHRPAVVLSSAAYNRIGLMLCCPLTTKLKGYPFEVAIDTDRPSAVLADQVKSFDW
RARGAKSKGRVSEVELSEIRAKARALIGR

Download         Length: 330 bp

>T53474 NZ_CP011121:160946-161275 [Acetobacter oryzifermentans]
ATGGTTGCCTACGTACCCGATGCTGGCGAAATCGTGTGGCTCGATTTTTCACCACAAATCGGACACGAGCAGGCGGGACA
TCGACCCGCAGTCGTTTTGTCATCGGCGGCTTATAATCGGATTGGTCTGATGCTGTGTTGTCCACTGACGACCAAGCTGA
AGGGCTATCCTTTTGAAGTTGCAATCGACACTGATCGACCGAGTGCGGTGCTCGCGGATCAGGTAAAGTCTTTCGATTGG
CGGGCGCGGGGTGCGAAGAGCAAAGGGCGCGTGTCTGAGGTAGAGCTATCGGAAATTCGGGCAAAAGCCCGTGCACTGAT
AGGCAGATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8921.28 Da        Isoelectric Point: 4.2550

>AT53474 WP_006115554.1 NZ_CP011121:160690-160944 [Acetobacter oryzifermentans]
MEGAMKAVVKKWGNSASIRIPASVLAAAGLTLDQPVDVREESGRIVIEPLTVVEYDLADLLAGITPENIHPEVDFGAPVG
RELL

Download         Length: 255 bp

>AT53474 NZ_CP011121:160690-160944 [Acetobacter oryzifermentans]
ATGGAGGGCGCAATGAAGGCTGTGGTAAAAAAATGGGGGAATAGTGCATCCATTCGTATCCCTGCTTCAGTATTGGCAGC
TGCTGGATTGACGTTGGATCAGCCAGTGGATGTGCGCGAGGAAAGCGGACGCATTGTCATTGAGCCGCTCACAGTCGTAG
AATACGATCTGGCGGATTTGTTGGCTGGGATCACCCCGGAGAATATTCATCCTGAAGTGGACTTCGGAGCGCCTGTTGGC
CGCGAACTCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1QFJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1QDC4

References