Detailed information of TA system TA053469

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1945957..1946547
• Replicon: chromosome
• Accession: NZ_CP011120
• Organism: Acetobacter oryzifermentans strain SLV-7

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: WG31_RS15020
• Protein ID: WP_082823179.1
• Coordinates: 1945957..1946139 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: WG31_RS09145
• Protein ID: WP_063354311.1
• Coordinates: 1946158..1946547 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WG31_RS09130	1941826..1943076	-	1251	WP_081461448.1	UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase	-
WG31_RS09135	1943434..1944009	+	576	WP_006116445.1	DedA family protein	-
WG31_RS09140	1944371..1945357	-	987	WP_006116444.1	UDP-glucose 4-epimerase GalE	-
WG31_RS15020	1945957..1946139	+	183	WP_082823179.1	type II toxin-antitoxin system HicA family toxin	Toxin
WG31_RS09145	1946158..1946547	+	390	WP_063354311.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
WG31_RS09150	1946715..1946987	+	273	WP_063354312.1	hypothetical protein	-
WG31_RS09155	1947054..1947506	+	453	WP_063354313.1	hypothetical protein	-
WG31_RS15915	1947507..1947953	+	447	WP_209439338.1	helix-turn-helix transcriptional regulator	-
WG31_RS09165	1948026..1948274	+	249	WP_063354315.1	hypothetical protein	-
WG31_RS09170	1948497..1948697	-	201	WP_063354316.1	hypothetical protein	-
WG31_RS09175	1948699..1949079	-	381	WP_063354317.1	hypothetical protein	-
WG31_RS09180	1949076..1949444	-	369	WP_063354318.1	hypothetical protein	-
WG31_RS15820	1949437..1949607	-	171	WP_167348734.1	hypothetical protein	-
WG31_RS09185	1949671..1950144	-	474	WP_063354319.1	hypothetical protein	-
WG31_RS09190	1950141..1950647	-	507	WP_063354320.1	hypothetical protein	-
WG31_RS09195	1950673..1951506	-	834	WP_063354321.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6682.87 Da
• Isoelectric Point: 11.5673

>T53469 WP_082823179.1 NZ_CP011120:1945957-1946139 [Acetobacter oryzifermentans]
MNSAALIKEMKKAGWTEIRVRGSHHQFRHPNHPHTVTVPHPKKDLGKGLVAAIKKQAGLK

Nucleotide

• Length: 183 bp

>T53469 NZ_CP011120:1945957-1946139 [Acetobacter oryzifermentans]
ATGAACAGCGCAGCACTCATTAAAGAAATGAAAAAGGCAGGATGGACAGAAATTCGAGTTCGTGGCTCTCACCACCAGTT
CAGGCACCCCAATCACCCTCACACGGTCACGGTGCCCCACCCTAAAAAAGATTTAGGTAAGGGACTCGTAGCTGCCATCA
AAAAACAAGCTGGGCTGAAATAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14237.08 Da
• Isoelectric Point: 4.4210

>AT53469 WP_063354311.1 NZ_CP011120:1946158-1946547 [Acetobacter oryzifermentans]
MRYPIVIEPGSETTSYGVVFPDLPGCFSAGDTLDEAVKNASKAAALWIEDALDNSEKVPAPSPLENVRDNPEWKNWIVGF
ADVDPMLFDTTAERVNITLPRRVLTRLDRRAKEEGETRSGFIARLAMGA

Nucleotide

• Length: 390 bp

>AT53469 NZ_CP011120:1946158-1946547 [Acetobacter oryzifermentans]
ATGCGCTATCCAATCGTAATTGAGCCGGGATCTGAAACCACATCTTACGGTGTTGTATTTCCAGACCTTCCCGGCTGCTT
CTCTGCCGGTGATACATTGGATGAGGCCGTTAAAAATGCGTCTAAAGCTGCTGCGCTGTGGATTGAAGATGCATTGGATA
ACAGCGAAAAAGTTCCTGCGCCTTCTCCGCTAGAAAACGTGCGAGACAACCCAGAATGGAAAAACTGGATTGTTGGTTTC
GCTGATGTTGATCCTATGCTGTTCGATACAACGGCGGAGCGTGTGAATATCACCCTGCCCCGGCGTGTTCTGACCCGACT
AGATAGGCGCGCAAAGGAAGAAGGAGAAACACGCTCTGGATTTATTGCCCGCTTAGCTATGGGCGCATGA