Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3451037..3451655 Replicon chromosome
Accession NZ_CP011118
Organism Yersinia enterocolitica strain FORC_002

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag FORC2_RS15845 Protein ID WP_002208622.1
Coordinates 3451452..3451655 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6TU35
Locus tag FORC2_RS15840 Protein ID WP_005167670.1
Coordinates 3451037..3451405 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC2_RS15805 3446700..3446960 + 261 WP_019081286.1 type B 50S ribosomal protein L31 -
FORC2_RS15810 3446976..3447119 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
FORC2_RS15815 3447247..3448125 - 879 WP_046695348.1 metal ABC transporter substrate-binding protein -
FORC2_RS15820 3448174..3449031 - 858 WP_005163445.1 metal ABC transporter permease -
FORC2_RS15825 3449028..3449756 - 729 WP_019081288.1 ABC transporter ATP-binding protein -
FORC2_RS15830 3449753..3449893 - 141 WP_172653924.1 hypothetical protein -
FORC2_RS15835 3450526..3450879 + 354 WP_046695349.1 hypothetical protein -
FORC2_RS15840 3451037..3451405 + 369 WP_005167670.1 Hha toxicity modulator TomB Antitoxin
FORC2_RS15845 3451452..3451655 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
FORC2_RS15850 3452498..3452803 + 306 WP_046695714.1 MGMT family protein -
FORC2_RS15855 3452855..3453385 - 531 WP_046051452.1 YbaY family lipoprotein -
FORC2_RS15860 3453643..3454506 + 864 WP_019082546.1 acyl-CoA thioesterase II -
FORC2_RS15865 3454601..3455890 - 1290 WP_005167660.1 ammonium transporter AmtB -
FORC2_RS15870 3455930..3456268 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T53468 WP_002208622.1 NZ_CP011118:3451452-3451655 [Yersinia enterocolitica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T53468 NZ_CP011118:3451452-3451655 [Yersinia enterocolitica]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14134.86 Da        Isoelectric Point: 4.4085

>AT53468 WP_005167670.1 NZ_CP011118:3451037-3451405 [Yersinia enterocolitica]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT53468 NZ_CP011118:3451037-3451405 [Yersinia enterocolitica]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGCGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACCAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A8B6L1C1

References