Detailed information of TA system TA053467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2426616..2427576
• Replicon: chromosome
• Accession: NZ_CP011118
• Organism: Yersinia enterocolitica strain FORC_002

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FORC2_RS10985
• Protein ID: WP_019079355.1
• Coordinates: 2427118..2427576 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FORC2_RS10980
• Protein ID: WP_046695019.1
• Coordinates: 2426616..2427062 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC2_RS10960	2422298..2423005	+	708	WP_046695018.1	murein tripeptide amidase MpaA	-
FORC2_RS10965	2423002..2423973	-	972	WP_019083076.1	L-Ala-D/L-Glu epimerase	-
FORC2_RS10970	2424126..2424629	+	504	WP_005161000.1	thiol peroxidase	-
FORC2_RS10975	2424713..2426296	-	1584	WP_019079357.1	transcriptional regulator TyrR	-
FORC2_RS10980	2426616..2427062	+	447	WP_046695019.1	DUF2384 domain-containing protein	Antitoxin
FORC2_RS10985	2427118..2427576	+	459	WP_019079355.1	RES family NAD+ phosphorylase	Toxin
FORC2_RS10990	2427579..2428643	-	1065	WP_046695020.1	YcjF family protein	-
FORC2_RS10995	2428640..2430037	-	1398	WP_046050953.1	YcjX family protein	-
FORC2_RS11000	2430018..2430257	-	240	WP_005169543.1	phage shock protein PspD	-
FORC2_RS11005	2430303..2430698	-	396	WP_161803522.1	envelope stress response membrane protein PspC	-
FORC2_RS11010	2430707..2430934	-	228	WP_019079351.1	envelope stress response membrane protein PspB	-
FORC2_RS11015	2431163..2431828	-	666	WP_046695022.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17205.62 Da
• Isoelectric Point: 4.6956

>T53467 WP_019079355.1 NZ_CP011118:2427118-2427576 [Yersinia enterocolitica]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTDWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPRHKSFQACLSSVQPLSFAFDPRLK

Nucleotide

• Length: 459 bp

>T53467 NZ_CP011118:2427118-2427576 [Yersinia enterocolitica]
ATGATGCTCTACCGCATTGTGATGCGCCGCTATCTTGCCTCAACCTGGACCGGCTATGGTGCCGAAATCTATGGTGGCCG
CTGGAATCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTATCACTGGCGATGTTGGAGACGTTGGTACATATTC
AGGACAGCTCAACACTAAGTGAGTTCGAGTTATTCCAAATTGAAATCGAAGATAGCAACATTATGCTGCTTCAGCCGCAG
GATTGGCCCACGGACTGGCGCAGCGACCCCGCACCTGCGACCACAATGGATATCGGCACTGAATGGCTGGAGTCAGAATC
ATCACTTGGATTACTGGTTCCATCCACTCTGGTGCCGACAGAAAACAATCTACTGCTCAATCCTCGGCACAAAAGCTTTC
AAGCCTGCCTAAGCAGTGTTCAACCGCTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16267.69 Da
• Isoelectric Point: 9.1260

>AT53467 WP_046695019.1 NZ_CP011118:2426616-2427062 [Yersinia enterocolitica]
MRTYHPTPATKTGALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT53467 NZ_CP011118:2426616-2427062 [Yersinia enterocolitica]
ATGAGAACATATCACCCCACTCCAGCGACCAAAACAGGGGCGCTATGGCGAGAGATTGGTTTGCCCGCGAGCCGCGGTAC
TGTATTGGTCGATAGCATCAAAATGGGTTTTTCTGTTGATGTCATTGACAGCATCCATCTATGGGCATCAATCCCCAAAG
CTGAAATCTTGCGTGCGACCGGCATTCCCAGCCGCAGCTTGACTCGCAGACGCACACATGATGGCCGTTTCACTCCCGAA
GAGAGTGAGCGAATTGCGCGTTTTGTTCGGGTTATGGACGCCGCAGTTGATCTATTTGGCGGAGATAAAGGCAAAGCTAT
CACTTGGATGTCGACCCCGATTAAAGGCCTGGGTCACCGTAGTCCGGATTCCTTACTGGAAACCGAAACCGGTGCATTGG
AAGTCTGTGATTTGATTGGACGCCTGGAGCACGGCGTATTTTCATAA