Detailed information of TA system TA053455

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 40044..40687
• Replicon: chromosome
• Accession: NZ_CP011118
• Organism: Yersinia enterocolitica strain FORC_002

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: FORC2_RS00170
• Protein ID: WP_046051923.1
• Coordinates: 40268..40687 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A0E1NFG4
• Locus tag: FORC2_RS00165
• Protein ID: WP_005161959.1
• Coordinates: 40044..40271 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC2_RS00140	35419..36579	+	1161	WP_019081443.1	mannitol-1-phosphate 5-dehydrogenase	-
FORC2_RS00145	36676..37230	+	555	WP_005161972.1	MltR family transcriptional regulator	-
FORC2_RS00150	37227..37838	-	612	WP_046051925.1	LysE family translocator	-
FORC2_RS00155	37982..39463	+	1482	WP_046695633.1	PLP-dependent aminotransferase family protein	-
FORC2_RS00160	39556..39912	+	357	WP_005161962.1	YibL family ribosome-associated protein	-
FORC2_RS00165	40044..40271	+	228	WP_005161959.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FORC2_RS00170	40268..40687	+	420	WP_046051923.1	type II toxin-antitoxin system VapC family toxin	Toxin
FORC2_RS00175	40843..41514	-	672	WP_046694356.1	6-N-hydroxylaminopurine resistance protein	-
FORC2_RS00180	41593..43542	-	1950	WP_046694357.1	methyl-accepting chemotaxis protein	-
FORC2_RS00185	43862..44485	-	624	WP_013650637.1	superoxide dismutase [Mn]	-
FORC2_RS00190	44612..45481	-	870	WP_046694358.1	formate dehydrogenase accessory sulfurtransferase FdhD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-131)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15580.20 Da
• Isoelectric Point: 9.0596

>T53455 WP_046051923.1 NZ_CP011118:40268-40687 [Yersinia enterocolitica]
MIKKLYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDAILPWDV
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAVSAGAILVTNNIREFERVKKLRIEDWTQ

Nucleotide

• Length: 420 bp

>T53455 NZ_CP011118:40268-40687 [Yersinia enterocolitica]
ATGATCAAAAAATTATATATGCTTGATACGAATATTTGTTCTTTTATTATGCGAGAACGACCAGCAGAATTAATTATAAA
ATTACAACAGTGTATTGAGCATCAGAATAAAATAGTTGTTTCAGCAATTACATACTCAGAAATGCGGTTCGGCGCTATAG
GTAAGAAAGCATCTCCAAAGCATAATTATTTAGTTGATGAATTTGTAAAAAGGTTAGATGCTATTTTACCGTGGGATGTC
GCAGCTGTTGATGCCACGACTAATATTAAAGTTGAGCTGGCAAAGCAGGGGACACCAATTGGTGGAAATGATGCCGCAAT
AGCCGGGCATGCAGTTTCTGCTGGAGCAATATTAGTAACTAATAATATTAGAGAGTTTGAACGAGTTAAAAAACTACGAA
TTGAAGATTGGACTCAATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8786.91 Da
• Isoelectric Point: 4.1971

>AT53455 WP_005161959.1 NZ_CP011118:40044-40271 [Yersinia enterocolitica]
MRTVSIFKNGQNRAIRLPKDMDFDGVTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Nucleotide

• Length: 228 bp

>AT53455 NZ_CP011118:40044-40271 [Yersinia enterocolitica]
ATGAGAACAGTATCTATTTTCAAAAATGGGCAGAATCGAGCAATTCGTTTGCCAAAAGATATGGATTTTGATGGCGTGAC
CGAGCTGGAAATACTCAGAGACGGTGATAGTATTATTTTACGACCCATACGCCCGACATGGGTATCATTCATGGATGAAG
ATAAGGCAGATGATGATTTTCTTGCCGAAAGACAGGATGTTATCGAAGAAGGACGCTTCGAGTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E1NFG4