Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/-
Location 22603..23209 Replicon chromosome
Accession NZ_CP011117
Organism Pseudomonas synxantha strain LBUM223

Toxin (Protein)


Gene name PfiT Uniprot ID -
Locus tag VO64_RS00120 Protein ID WP_046067907.1
Coordinates 22603..22947 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID -
Locus tag VO64_RS00125 Protein ID WP_046067908.1
Coordinates 22961..23209 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VO64_RS00095 18339..18524 + 186 Protein_17 transposase domain-containing protein -
VO64_RS00100 18818..19726 - 909 WP_046067904.1 hypothetical protein -
VO64_RS00105 19930..20910 - 981 Protein_19 IS5 family transposase -
VO64_RS00110 20998..21401 - 404 Protein_20 transposase -
VO64_RS00120 22603..22947 - 345 WP_046067907.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VO64_RS00125 22961..23209 - 249 WP_046067908.1 prevent-host-death protein Antitoxin
VO64_RS00130 23451..24554 - 1104 WP_046067909.1 IS5 family transposase -
VO64_RS00135 24682..25659 + 978 WP_046072428.1 IS5 family transposase -
VO64_RS00140 26069..26296 - 228 WP_046072429.1 hypothetical protein -
VO64_RS00145 26510..26731 - 222 WP_046072430.1 hypothetical protein -
VO64_RS00150 26847..27761 - 915 WP_046067910.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4320..39889 35569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12953.81 Da        Isoelectric Point: 5.9545

>T53450 WP_046067907.1 NZ_CP011117:c22947-22603 [Pseudomonas synxantha]
MTTLTIRYTNIAQQSIEDQIEHLAGFHGLGHAVDRLDTVINTLQYKLLSAPLAYPISPQASDLGILHYRELNTDGYRVFY
ETIEADQAIVVLLLLRNKQSVENALIRYCLLHTQ

Download         Length: 345 bp

>T53450 NZ_CP011117:c22947-22603 [Pseudomonas synxantha]
ATGACAACACTAACAATCCGCTACACCAACATTGCACAACAGAGTATCGAAGACCAGATCGAGCATCTGGCAGGCTTTCA
TGGCCTGGGCCATGCCGTTGATCGGTTAGACACTGTGATTAACACCCTTCAATACAAGCTACTGTCCGCTCCATTAGCCT
ATCCAATCAGCCCTCAAGCCAGCGATCTGGGTATCCTGCACTACCGCGAACTCAATACCGATGGGTACCGAGTGTTCTAT
GAAACCATAGAAGCGGACCAGGCAATCGTCGTTCTTTTGCTGCTGCGGAATAAACAAAGCGTAGAAAATGCACTGATTCG
ATACTGTCTACTGCATACGCAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9377.78 Da        Isoelectric Point: 9.4828

>AT53450 WP_046067908.1 NZ_CP011117:c23209-22961 [Pseudomonas synxantha]
MRVETVSFLKKYASDLPLEEPMVVTQNGVPAYVVESYAERKSRDETIALVKLLAMSSREYSQGKHCSTDELKARLSKRFA
HR

Download         Length: 249 bp

>AT53450 NZ_CP011117:c23209-22961 [Pseudomonas synxantha]
ATGCGAGTAGAAACAGTTAGCTTTCTAAAGAAATACGCATCCGACCTGCCGCTGGAAGAGCCGATGGTCGTCACGCAAAA
CGGTGTGCCTGCATACGTTGTGGAATCTTACGCTGAGCGTAAGAGCCGCGATGAAACGATAGCCCTAGTGAAACTGCTCG
CAATGAGTTCTCGCGAGTATTCCCAAGGCAAACATTGTTCGACTGATGAACTGAAAGCCCGCTTGAGCAAGAGGTTTGCC
CACAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References